Indefinite Sturm-Liouville operators defined on R are often considered as a coupling of two semibounded symmetric operators defined on R + and R − , respectively. In many situations, those two semibounded symmetric operators have in a special sense good properties like a Hilbert space self-adjoint extension.In this paper, we present an abstract approach to the coupling of two (definitizable) self-adjoint operators. We obtain a characterization for the definitizability and the regularity of the critical points. Finally we study a typical class of indefinite Sturm-Liouville problems on R.