Linear lichen planus after <scp>COVID</scp>‐19 vaccination

Kato, Junji; Kamiya, Takafumi; Handa, Toshiya; Kobayashi, Eri; Hida, Tokimasa; Yamashita, Toshiharu; Uhara, Hisashi

doi:10.1111/ajd.13902

Cited by 6 publications

(11 citation statements)

References 9 publications

(9 reference statements)

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“…A review of the world literature describing COVID-19 vaccine-associated cases of cutaneous lichen planus and lichenoid eruptions is summarized in Table 2 . The search produced twenty-eight articles that discussed 31 cases of COVID-19 vaccine-associated lichenoid eruptions [ 35 , 36 , 37 , 38 , 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 , 63 ].…”

Section: Resultsmentioning

confidence: 99%

“…The pathology showed lichenoid interface dermatitis with or without dermal eosinophils. Since that time, published case reports [ 39 , 40 , 41 , 42 , 43 , 44 , 45 , 46 , 47 , 48 , 49 , 50 , 51 , 52 , 53 , 54 , 55 , 56 , 57 , 58 , 59 , 60 , 61 , 62 ] and one small case series [ 63 ] cumulatively report on 29 additional patients. New-onset and reactivation of oral lichen planus has also been reported [ 43 , 64 , 65 ].…”

Section: Resultsmentioning

confidence: 99%

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COVID-19 Vaccine-Induced Lichenoid Eruptions—Clinical and Histopathologic Spectrum in a Case Series of Fifteen Patients with Review of the Literature

et al. 2023

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Lichen planus is a distinctive mucocutaneous disease with well-established clinical and histopathologic criteria. Lichenoid eruptions closely resemble lichen planus and may sometimes be indistinguishable from it. Systemic agents previously associated have included medications, viral infections and vaccines. Sporadic case reports of lichen planus and lichenoid reactions associated with COVID-19 vaccines have recently emerged. Herein, we review the world literature (31 patients) and expand it with a case series of 15 patients who presented with vaccine-induced lichenoid eruption (V-ILE). The spectrum of clinical and histopathologic findings is discussed with emphasis on the subset whose lesions manifested in embryologic fusion lines termed lines of Blaschko. This rare Blaschkoid distribution appeared in seven of the 46 patients studied. Of interest, all seven were linked to the mRNA COVID-19 vaccines. We believe that all lichenoid eruptions should be approached with a heightened index of suspicion and patients should be specifically questioned with regards to their vaccination history. When diagnosed early in its course, V-ILE is easily treated and resolves quickly in almost all patients with or without hyperpigmentation. Additional investigative studies regarding its immunopathology and inflammatory signaling pathways may offer insight into other Th1-driven autoimmune phenomena related to COVID-19 vaccination.

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Section: Resultsmentioning

confidence: 99%

Section: Resultsmentioning

confidence: 99%

COVID-19 Vaccine-Induced Lichenoid Eruptions—Clinical and Histopathologic Spectrum in a Case Series of Fifteen Patients with Review of the Literature

et al. 2023

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“…61 To date, 13 cases of new-onset cutaneous lichen planus and 3 cases of cutaneous lichen planus exacerbation have been reported. [62][63][64][65][66][67][68][69][70][71][72][73][74][75][76] Like psoriasis, also cases of new onset and flare of atopic dermatitis or eczema have been reported (7 and 14, respectively). [77][78][79][80][81][82][83] However, there is not a clear correlation with clinical phenotypes.…”

Section: Resultsmentioning

confidence: 99%

“… BNT162b2: 10 mRNA-1273: 3 AZD1222: 3 Ad26.COV2: 1 Flare of psoriasis 81 Huang et al 29 (15), Sotiriou et al 30 (14), Koumaki et al 31 (12), Megna et al 32 (11), Wei et al 53 (6), Ruggiero et al 26 (4), Durmaz et al 33 (2), Tran et al 34 (2), Piccolo et al 36 (2), Bostan et al 37 (1), Nagrani et al 35 (1), Pavia et al 38 (1), Durmus et al 39 (1), Fang et al 40 (1), Krajewski et al 41 (1), Trepanowski et al 42 (1), Mieczkowska et al 43 (1), Lopez et al 44 (1), Perna et al 45 (1), Tsunoda et al 47 (1), Nia et al 48 (1), Pesqué et al 28 (1). BNT162b2: 43 mRNA-1273: 17 AZD1222: 21 Ad26.COV2: 0 Cutaneous lichen planus 16 New-onset: Merhy et al 62 (1), Camela et al 63 (1), Kato et al 69 (1), Diab et al 70 (1), Zagaria et al 71 (1), Awada et al 72 (1), Picone et al 73 (1), Hlaca et al 74 (1), Zengarini et al 75 (1), Masseran et al 76 (1), Gamonal et al 64 (1), Alrawashdeh et al 65 (1), Shakoei et al 66 (1). Flare: Hiltun et al 67 (1), Herzum et al 68 (1), Hlaca et al 74 (1).…”

Section: Methodsmentioning

confidence: 99%

“…(1). Merhy et al62 (1), Camela et al63 (1), Kato et al69 (1), Diab et al70 (1), Zagaria et al71 (1), Awada et al72 (1), Picone et al73 (1), Hlaca et al74 (1), Zengarini et al75 (1), Masseran et al76 (1), Gamonal et al64 (1), Alrawashdeh et al65 (1), Shakoei et al66 (1). Zou et al122 (3), Gui et al123 (2), Rouatbi et al124 (2), Aryanian et al125 (1), Koutlas et al126 (1), Knechtl et al127 (1), Ong et al128 (1), Yıldırıcı et al129 (1), Singh et al130 (1), Norimatsu et al131 (1), Agharbi et al132 (1), Almasi-Nasrabadi et al133 (1),…”

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confidence: 99%

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Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature

Battista¹,

Marasca²,

Genco³

et al. 2022

CCID

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The outbreak of coronavirus disease 2019 represented a new worldwide challenge, strongly impacting on the global economy, overall health and lifestyle. Since then, several strategies have been adopted to contain the widespread of infection. Among these, vaccination is currently the most important measure to fight against the pandemic. However, several concerns such as slower-than-hoped-for rollout, the hurried approval with limited data, the mechanism of action (in particular mRNA-based), and the uncertain duration of protection they afforded were initially raised. Moreover, even if cutaneous reactions have been rarely reported in clinical trials, global mass vaccination showed several dermatologic reactions not initially recognized, leaving dermatologists to decide how to diagnose and treat them. In this scenario, dermatologists should be ready to promptly recognize these clinical manifestations. Thus, the aim of this manuscript is to review current literature on cutaneous reactions following COVID-19 vaccination, particularly inflammatory dermatological diseases, in order to help clinicians to better understand these dermatological conditions and to provide an extensive overview of all the vaccine-related skin manifestations.

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A Review of Linear Lichen Planus Case Reports

Rousseau,

Nelson,

Rashid

2024

The American Journal of Dermatopathology

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Lichen linear planus is a rare variant of lichen planus that appears as pruritic, polygonal, purple papules in a blaschkoid distribution. This review critically assesses all reported cases of linear lichen planus (LLP) for proposed etiology, clinical and histologic traits, treatment options, and recurrence. A PubMed search from inception through March 2023, followed by article screening and full-text review, identified 51 unique cases of LLP. Data from each case including the sex of the patient, anatomic distribution of lesions, biopsy results, proposed etiology, treatment, and recurrence were recorded. LLP did not show a significant gender or age predilection, most frequently presented unilaterally with pruritus, and involved numerous anatomic regions. Various triggers including metal implants, vaccinations, infections, malignancy, and pregnancy were identified. The most common histopathologic descriptions included band-like lymphocytic or lichenoid infiltrate, basal liquefactive, vacuolar degeneration, hypergranulosis, hyperkeratosis, civatte or colloid bodies, melanin incontinence, and orthokeratosis. Treatment options, duration of treatment, and recurrence rate of LLP lesions were variable. Although LLP is rare, dermatologists should be aware of this presentation and appropriate diagnostic and treatment options because swift diagnosis can reduce patient morbidity.

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Linear lichen planus after COVID‐19 vaccination

Cited by 6 publications

References 9 publications

COVID-19 Vaccine-Induced Lichenoid Eruptions—Clinical and Histopathologic Spectrum in a Case Series of Fifteen Patients with Review of the Literature

COVID-19 Vaccine-Induced Lichenoid Eruptions—Clinical and Histopathologic Spectrum in a Case Series of Fifteen Patients with Review of the Literature

Cutaneous Reactions Following COVID-19 Vaccination: A Review of the Current Literature

A Review of Linear Lichen Planus Case Reports

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