Linear IgA disease and desquamative gingivitis: time for inclusion in mucous membrane pemphigoid

Torchia, Daniele; Caproni, Marzia; Fabbri, Paolo

doi:10.1111/j.1601-0825.2008.01485.x

Cited by 10 publications

(5 citation statements)

References 12 publications

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“…These recommendations have been widely accepted in dermatology, but not always in dentistry (Torchia et al , ; Betts et al , ; Dan et al , ), as confirmed by our analysis of reported cases. More importantly, almost all the published cases of oral LAD did not show any common features clinically, histologically, and/or immunologically to justify a diagnosis different from MMP.…”

Section: Discussionsupporting

confidence: 85%

Urban legend series: mucous membrane pemphigoid

Zenzo

Carrozzo

Chan³

2013

Oral Diseases

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Mucous membrane pemphigoid (MMP) is a heterogeneous group of autoimmune subepithelial blistering diseases affecting primarily mucous membranes showing marked degree of clinical and immunological variability. We investigated four controversial topics: (i) Does oral pemphigoid (OP) really exist as a separate entity? (ii) Is mucous membrane pemphigoid curable? (iii) What is the best therapeutic option for MMP? (iv) Does exclusive oral IgA dermatitis exist as a distinct entity from MMP? Results from extensive literature searches suggested that (i) it is still unclear whether patients with OP could be considered as a distinct subset of MMP with specific clinical and immunological features; (ii) it is uncertain whether treatment regimens that get MMP under control can be eliminated to allow patients to be in drug-free remission or they should be continuously administered in some capacities; (iii) there is a concerning paucity of good-quality trials on MMP and available recommendations are solely based on generally small patients' cohorts or case series. Some of the 2002 consensus experts' opinions should be possibly updated, particularly regarding the safety of sulfa drugs; (iv) we did not find any strong evidence to support an exclusive oral (and perhaps also mucosal) form of LAD as a separate entity.

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Section: Discussionsupporting

confidence: 85%

Urban legend series: mucous membrane pemphigoid

Zenzo

Carrozzo

Chan³

2013

Oral Diseases

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“…Other mucocutaneous conditions, characterized as vesicle‐bullous conditions, include linear IgA disease, bullous epidermolisis, erythema multiforme and lupus erythematosus. When affecting the gingiva, they manifest as desquamative gingivitis and the differential diagnosis should be based on histologic or laboratory evidence, as well as the involvement of other body sites or organs .…”

Section: Other Acute Conditions In the Periodontiummentioning

confidence: 99%

Acute periodontal lesions

Herrera¹,

Alonso²,

Arriba³

et al. 2014

Periodontology 2000

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This is a review and update on acute conditions affecting the gingival tissues, including abscesses in the periodontium, necrotizing periodontal diseases, and other acute conditions that cause gingival lesions with acute presentation, such as infectious processes not associated with oral bacterial biofilms, muco--cutaneous disorders, and traumatic and allergic lesions. A periodontal abscess is clinically important since it is a relatively frequent dental emergency, it can compromise the periodontal prognosis of the affected tooth, and because bacteria within the abscess can spread and cause infections in other body sites. Different types of abscesses have been identified, mainly by the type of etiology, and there are clear differences between those affecting a previously existing periodontal pocket and those affecting healthy sites. Therapy for this acute condition consists of drainage and tissue debridement, with individual evaluation of the need for systemic antimicrobial therapy. The definitive treatment of the pre--existing condition should be accomplished after the acute phase is controlled.

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“…In mucous membrane pemphigoid (MMP) patients, the presence of IgA antibodies alone is relatively rare in the absence of IgG antibodies [ 41 ]. In some patients with only mucosal involvement, only IgA antibody can be found in DIF; a diagnosis of LABD might have been previously established [ 42 ].…”

Section: Iga-related Mucous Membrane Pemphigoidmentioning

confidence: 99%

Antigen recognition in the pathogenesis of immunoglobulin A-related autoimmune bullous diseases

Li¹,

Jing²,

Li³

et al. 2018

pdia

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Immunoglobulin A (IgA) is the most common subtype of antibodies in mucosal surfaces. In most of autoimmune bullous diseases, however, immunoglobulin G (IgG) is the main pathogenic antibody that plays a role through complementation. The IgA antibody for epidermal connection protein can be found in the sera of some patients with blistering skin disease. Of these patients, some have the IgA antibody in their sera, while others have IgG and IgA antibodies. IgA-related autoimmune bullous diseases are less common in clinical practice. In the past, these diseases were not fully understood and their classifications were confusing. Recently, some progress has been made in the study of these diseases.

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Linear IgA disease and desquamative gingivitis: time for inclusion in mucous membrane pemphigoid

Cited by 10 publications

References 12 publications

Urban legend series: mucous membrane pemphigoid

Urban legend series: mucous membrane pemphigoid

Acute periodontal lesions

Antigen recognition in the pathogenesis of immunoglobulin A-related autoimmune bullous diseases

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