2014
DOI: 10.7241/ourd.20141.19
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Linear IgA bullous disease with possible immunoreactivity to the basement membrane zone and dermal blood vessels

Abstract: Introduction: Linear IgA bullous dermatosis (LAD) is an immunobullous disorder, in which IgA antibodies are deposited along the basement membrane zone (BMZ) of the skin in a linear pattern. The cause of this disease is unknown, but the eruption may occur more commonly in association with certain medications. Case report: A 61 year old woman presented with blisters in the axillae and legs, with pain, itching and swelling. She was taking many medications for other conditions such diabetes and obesity. Tense blis… Show more

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“…Its exact etiology is yet unknown but resembles class II Schwartzman-like hypersensitivity reactions. Initially a single pustular lesion, it is known to progress rapidly, causing painful ulcerated nodules or plaques with undermined, dusky, and violaceous borders that heal with cribriform scarring [3]. Though commonly associated with other inflammatory, infectious, and malignant pathologies, it may at times be idiopathic with no relevant causative factors [4].…”
Section: Discussionmentioning
confidence: 99%
“…Its exact etiology is yet unknown but resembles class II Schwartzman-like hypersensitivity reactions. Initially a single pustular lesion, it is known to progress rapidly, causing painful ulcerated nodules or plaques with undermined, dusky, and violaceous borders that heal with cribriform scarring [3]. Though commonly associated with other inflammatory, infectious, and malignant pathologies, it may at times be idiopathic with no relevant causative factors [4].…”
Section: Discussionmentioning
confidence: 99%