Linear cutaneous leishmaniasis occurring on a leg affected by tuberculoid leprosy

Al-Aboud, Khalid; Al-Hawasawi, K.; Ramesh, V.; Al-Aboud, D.; Al-Githami, A.

doi:10.1046/j.1365-2133.2002.49714.x

Cited by 6 publications

(4 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Nonetheless, follow-up of one patient suggested that IL-10–mediated regulatory responses induced during leprosy may help control the immunopathology of mucosal leishmaniasis [ 78 , 79 ]. Twenty other patients described in the literature had disease manifestations of leprosy and TL that were not that far apart on the disease spectrum [ 6 , 70 , 73 , 74 , 76 , 80 – 82 ].…”

Section: Resultsmentioning

confidence: 99%

Tegumentary leishmaniasis and coinfections other than HIV

et al. 2018

View full text Add to dashboard Cite

BackgroundTegumentary leishmaniasis (TL) is a disease of skin and/or mucosal tissues caused by Leishmania parasites. TL patients may concurrently carry other pathogens, which may influence the clinical outcome of TL.Methodology and principal findingsThis review focuses on the frequency of TL coinfections in human populations, interactions between Leishmania and other pathogens in animal models and human subjects, and implications of TL coinfections for clinical practice. For the purpose of this review, TL is defined as all forms of cutaneous (localised, disseminated, or diffuse) and mucocutaneous leishmaniasis. Human immunodeficiency virus (HIV) coinfection, superinfection with skin bacteria, and skin manifestations of visceral leishmaniasis are not included. We searched MEDLINE and other databases and included 73 records: 21 experimental studies in animals and 52 studies about human subjects (mainly cross-sectional and case studies). Several reports describe the frequency of Trypanosoma cruzi coinfection in TL patients in Argentina (about 41%) and the frequency of helminthiasis in TL patients in Brazil (15% to 88%). Different hypotheses have been explored about mechanisms of interaction between different microorganisms, but no clear answers emerge. Such interactions may involve innate immunity coupled with regulatory networks that affect quality and quantity of acquired immune responses. Diagnostic problems may occur when concurrent infections cause similar lesions (e.g., TL and leprosy), when different pathogens are present in the same lesions (e.g., Leishmania and Sporothrix schenckii), or when similarities between phylogenetically close pathogens affect accuracy of diagnostic tests (e.g., serology for leishmaniasis and Chagas disease). Some coinfections (e.g., helminthiasis) appear to reduce the effectiveness of antileishmanial treatment, and drug combinations may cause cumulative adverse effects.Conclusions and significanceIn patients with TL, coinfection is frequent, it can lead to diagnostic errors and delays, and it can influence the effectiveness and safety of treatment. More research is needed to unravel how coinfections interfere with the pathogenesis of TL.

show abstract

Section: Resultsmentioning

confidence: 99%

Tegumentary leishmaniasis and coinfections other than HIV

et al. 2018

View full text Add to dashboard Cite

show abstract

“…Chronic form of cutaneous leishmaniasis, known as leishmaniasis recidivans caused by L. tropica and L. braziliensis , can mimic lupus vulgaris. Leishmaniasis presenting as multiple ulcerated nodules in linear distribution over the left leg and few scattered lesions on the right leg has been described 6 …”

Section: Discussionmentioning

confidence: 99%

Linear figurate plaques with hemorrhagic bullae and ulceration on the leg

et al. 2020

Self Cite

View full text Add to dashboard Cite

“…Nevertheless, an exact comparison with our study is difficult because L. (L.) tropica was the causative pathogen in these patients. Likewise, comorbidity of leishmaniasis with the BL clinical leprosy form 5 and TT leprosy 6 has been reported in India. Nevertheless, the anergic pole was attributed to the Leishmania spp.…”

mentioning

confidence: 94%

“…Although both diseases are prevalent in some countries, reports on comorbidity in the same patient are scarce. In 1978, 8 patients with coinfections of leprosy and cutaneous leishmaniasis (CL) were reported in Ethiopia 3 , followed by reports of ATL-leprosy concurrence in Venezuela 4 , India 5,6 , Northeastern Brazil 7 , Southeastern Brazil [8][9][10][11][12] , and Central America 13 .…”

mentioning

confidence: 99%