Linear Blood Velocity in Arteries of the Brain Hemispheres in Left-Handers and Right-Handers during Hypoxia

Leutin, V. P.; Pystina, E. A.; Yarosh, S. V.

doi:10.1023/b:hump.0000029174.77068.5b

Cited by 5 publications

(4 citation statements)

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“…Moreover, previous research also provides evidence for an association between handedness and anatomy (Chang et al 1960; Weber et al 2006). Interestingly, previous research has shown that bifurcation of the common carotid artery was asymmetrical (Smith and Larsen 1979) and, although we are not aware of a demonstrated relationship with other laterality measures, blood velocity in the middle cerebral artery has been shown to differ in an asymmetrical manner between left‐ and right‐handed individuals during hypoxia (Leutin et al 2004) hinting at the possibility of different vascular vulnerabilities of the left and right hemispheres between handedness groups. Since vascular risks have been clearly demonstrated in dementia and cognitive decline, even a subtle life‐long handedness‐related influence might provide some insights into findings showing an association between the onset and course of dementia and handedness (Seltzer et al 1984; de Leon et al 1986; Doody et al 1999).…”

Section: Discussionmentioning

confidence: 71%

Mixed handedness is associated with greater age‐related decline in volumes of the hippocampus and amygdala: the PATH through life study

Sachdev

Anstey

2011

Brain and Behavior

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Handedness has been found to be associated with structural and functional cerebral differences. Left handedness and mixed handedness also appear to be associated with an elevated risk of some developmental and immunological disorders that may contribute to pathological processes developing in ageing. Inconsistent reports show that left handedness may be more prevalent in early-onset as well as late-onset Alzheimer's disease, but might also be associated with slower decline. Such inconsistencies may be due to handedness being usually modeled as a binary construct while substantial evidence suggests it to be a continuous trait. The aim of this study was to investigate the relationship between brain structures known to be implicated in pathological ageing and strength and direction of handedness. The association between handedness and hippocampal and amygdalar atrophy was investigated in 327 cognitively healthy older individuals. Handedness was measured with the Edinburgh Inventory. Two measures were computed from this index, one reflecting the direction (left = 0/right = 1) and the other the degree of handedness (ranging from 0 to 1). Hippocampal and amygdalar volumes were manually traced on scans acquired 4 years apart. Regression analyses were used to assess the relationship between strength and direction of handedness and incident hippocampal and amygdalar atrophy. Analyses showed that strength but not direction of handedness was a significant predictor of hippocampal (Left: beta = 0.118, P = 0.013; Right: beta = 0.116, P = 0.010) and amygdalar (Right: beta = 0.105, P = 0.040) atrophy. The present findings suggest that mixed but not left handedness is associated with greater hippocampal and amygdalar atrophy. This effect may be due to genetic, environmental, or behavioural differences that will need further investigation in future studies.

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Section: Discussionmentioning

confidence: 71%

Mixed handedness is associated with greater age‐related decline in volumes of the hippocampus and amygdala: the PATH through life study

Sachdev

Anstey

2011

Brain and Behavior

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“…It was shown, for example, that the linear bloodfl ow velocity decreased greater in the LH of right-handed individuals [7]. Intermittent normobaric hypoxia, similarly as antihypoxant amtizol, led to increase of hypoxic resistance of humans and animals.…”

Section: Resultsmentioning

confidence: 99%

Effect of Amtizol on Resistance of SHR Mice to Acute Hypoxia with Hypercapnia under Conditions of Isolated Functioning of One Cerebral Hemisphere

2013

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Antihypoxant amtizol (25 mg/kg) prolonged the lifespan of intact SHR mice by 46.2% under conditions of isolated functioning of one cerebral hemisphere. The effect of amtizol on sham-operated animals was less pronounced: the lifespan of mice was prolonged by just 28.1%. Injection of amtizol to mice with active right hemisphere significantly prolonged the lifespan of experimental animals (by 64.8%). The drug was ineffective under conditions of active left hemisphere: the result coincided with the lifespan of similar mice without the drug injection. Hence, antihypoxic effect of amtizol was largely determined by its effect on the right, but not the left cerebral hemisphere.

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“…In adults, left-right asymmetries are normal attributes of cerebral perfusion, akin to well-established asymmetries in brain morphology [26,27]. Cerebral arterial diameters and blood flows have been investigated in neonates for a variety of largely clinical ends.…”

Section: Discussionmentioning

confidence: 99%

Cerebral Arterial Asymmetries in the Neonate: Insight into the Pathogenesis of Stroke

et al. 2022

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Neonatal and adult strokes are more common in the left than in the right cerebral hemisphere in the middle cerebral arterial territory, and adult extracranial and intracranial vessels are systematically left-dominant. The aim of the research reported here was to determine whether the asymmetric vascular ground plan found in adults was present in healthy term neonates (n = 97). A new transcranial Doppler ultrasonography dual-view scanning protocol, with concurrent B-flow and pulsed wave imaging, acquired multivariate data on the neonatal middle cerebral arterial structure and function. This study documents for the first-time systematic asymmetries in the middle cerebral artery origin and distal trunk of healthy term neonates and identifies commensurately asymmetric hemodynamic vulnerabilities. A systematic leftward arterial dominance was found in the arterial caliber and cortically directed blood flow. The endothelial wall shear stress was also asymmetric across the midline and varied according to vessels’ geometry. We conclude that the arterial structure and blood supply in the brain are laterally asymmetric in newborns. Unfavorable shearing forces, which are a by-product of the arterial asymmetries described here, might contribute to a greater risk of cerebrovascular pathology in the left hemisphere.

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Linear Blood Velocity in Arteries of the Brain Hemispheres in Left-Handers and Right-Handers during Hypoxia

Cited by 5 publications

References 0 publications

Mixed handedness is associated with greater age‐related decline in volumes of the hippocampus and amygdala: the PATH through life study

Mixed handedness is associated with greater age‐related decline in volumes of the hippocampus and amygdala: the PATH through life study

Effect of Amtizol on Resistance of SHR Mice to Acute Hypoxia with Hypercapnia under Conditions of Isolated Functioning of One Cerebral Hemisphere

Cerebral Arterial Asymmetries in the Neonate: Insight into the Pathogenesis of Stroke

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