Linear Assemblies of Magnetic Nanoparticles as MRI Contrast Agents

Corr, Serena A.; Byrne, Stephen J.; Tekoriute, Renata; Meledandri, Carla J.; Brougham, Dermot F.; Lynch, Marina A.; Kerskens, Christian; O’Dwyer, Laurence; Gun’ko, Yurii K.

doi:10.1021/ja710172z

Cited by 144 publications

(126 citation statements)

References 25 publications

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“…Some parameters such as NPs size and spatial distribution were studied by examining sample cross-sections by Scanning Electron Microscopy (SEM) (see Figure 9). Similar results were obtained for Ag@Co and Ag@ferrite (such as Fe 3 O 4 and MnFe 2 O 4 ) PSMNPs synthesized in different types of polymer matrices (sulfonic and carboxylic resins) following modified literature procedures (Corr at al., 2008, Alonso, 2011.…”

supporting

confidence: 78%

“…Systems based on these kinds of nanocomposites are employed in magnetic recording devices, ferrofluids, medical diagnosis, drug delivery, pigments for paintings and ceramics (Bastida et al, 2006). For example, a new family of potential contrast agents has been recently synthesized based on magnetic nanoparticles stabilized using commercially available polyelectrolytes (such as poly(sodium-4-styrene) sulfonate) that act as both nanocomposite assembly directors and water-stable surfactants, instead of the classical biopolyelectrolyte DNA (Corr et al, 2008;Davies et al, 2011). Hence, using straight-forward one-step procedures, magnetic fluids can be prepared.…”

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

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Environmentally-Safe Catalytically Active and Biocide Polymer-Metal Nanocomposites with Enhanced Structural Parameters

Alonso¹,

Macanás²,

Davies³

et al. 2011

Advances in Nanocomposite Technology

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supporting

confidence: 78%

Section: Magnetic Nanoparticlesmentioning

confidence: 99%

Environmentally-Safe Catalytically Active and Biocide Polymer-Metal Nanocomposites with Enhanced Structural Parameters

Alonso¹,

Macanás²,

Davies³

et al. 2011

Advances in Nanocomposite Technology

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“…Due to linear clustering, some high aspect ratio magnetic nanomaterials showed increased transverse relaxivity when compared to their spherical counterparts. 4,17,18 Anisotropic magnetic nanomaterials have higher magnetic moments than spherical ones and therefore can be manipulated using weaker magnetic fields, opening up new possibilities for magnetic targeted delivery and therapy, as well as for magnetic cell separation. 8 The review is organised as follows.…”

Section: Introductionmentioning

confidence: 99%

Shape matters: synthesis and biomedical applications of high aspect ratio magnetic nanomaterials

2015

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High aspect ratio magnetic nanomaterials possess anisotropic properties that make them attractive for biological applications. Their elongated shape enables multivalent interactions with receptors through the introduction of multiple targeting units on their surface, thus enhancing cell internalization. Moreover, due to their magnetic anisotropy, high aspect ratio nanomaterials can outperform their spherical analogues as contrast agents for magnetic resonance imaging (MRI) applications. In this review, we first describe the two main synthetic routes for the preparation of anisotropic magnetic nanomaterials: (i) direct synthesis (in which the anisotropic growth is directed by tuning the reaction conditions or by using templates) and (ii) assembly methods (in which the high aspect ratio is achieved by assembly from individual building blocks). We then provide an overview of the biomedical applications of anisotropic magnetic nanomaterials: magnetic separation and detection, targeted delivery and magnetic resonance imaging.

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“…MNPs are also used as a contrast agent for magnetic resonance imaging (MRI) due to its ability to reduce the T2 relaxation time of water molecules [34,35]. More importantly, MNPs can be utilized for magnetic drug targeting (MDT), which is an active drug targeting method.…”

Section: Introductionmentioning

confidence: 99%

Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging

Venugopal¹,

Pernal²,

Fusinatto³

et al. 2016

Nano BioMed ENG

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Nanotechnology is being increasingly applied for developing drug delivery options for specific treatments. Magnetic nanoparticles have drawn attention as drug delivery vehicles due to their stability, biocompatibility and ability to be non-invasively guided to desired target areas using magnetic fields. In this paper, we describe a new delivery vehicle for magnetic drug targeting. In magnetic drug targeting, drug functionalized magnetic nanoparticles are guided and localized at specific sites using external magnetic fields. Magnetic nanoparticles act as contrast agents for magnetic resonance imaging. However, it cannot be visualized via this technique during drug delivery. This is between magnetic fields used for imaging and delivery can interference with each other. Our laboratory has synthesized a magnetic drug targeting vehicle conjugated with quantum dots that can be imaged during the drug delivery process with in vivo imaging techniques such as fluorescence molecular tomography. These nanocomposites can be used as drug delivery vehicles for the central nervous system, where drug targeting is especially difficult and minimizing side effects is critical.

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Linear Assemblies of Magnetic Nanoparticles as MRI Contrast Agents

Cited by 144 publications

References 25 publications

Environmentally-Safe Catalytically Active and Biocide Polymer-Metal Nanocomposites with Enhanced Structural Parameters

Environmentally-Safe Catalytically Active and Biocide Polymer-Metal Nanocomposites with Enhanced Structural Parameters

Shape matters: synthesis and biomedical applications of high aspect ratio magnetic nanomaterials

Quantum Dot Conjugated Magnetic Nanoparticles for Targeted Drug Delivery and Imaging

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