Linear areas of echogenicity in the thalami and basal ganglia of neonates: an expanded association. Work in progress.

Hughes, P. M.; Weinberger, Edward; Shaw, Dennis

doi:10.1148/radiology.179.1.1848713

Cited by 56 publications

(54 citation statements)

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“…Linear or punctuate BGTH, although often associated with lenticulostriate vasculopathy (with basophilic deposits in arterial walls, perivascular infiltrates and mineralizing coagulative necrosis), 1,11 may occur in the absence of pathologic vascular or perivascular anomalies. 30 Whether immunologic factors (in infants of HIVinfected mothers in the absence of perinatal HIV infection) or hyperviscosity (in recipients from twin-to-twin transfusion syndrome) 24 may contribute to lenticulostriate vessel hyperechogenicity remains to be determined.…”

Section: Discussionmentioning

confidence: 99%

Diffuse basal ganglia or thalamus hyperechogenicity in preterm infants

et al. 2006

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Objective: To determine the incidence and factors associated with diffuse basal ganglia or thalamus hyperechogenicity (BGTH) in preterm infants.Study Design: (1) Review of serial neurosonograms among neonates with gestational age (GA) <34 weeks born at Weiler Hospital during a 21-month period; (2) Color Doppler flow imaging; (3) Case-control study using GA group-matched controls; and (4) Blind reading of CT scans or MRIs in patients with BGTH.Results: Among 289 infants, 24 (8.3%) had diffuse BGTH. Color Doppler flow imaging was normal in nine patients. The incidence of diffuse BGTH was inversely related to GA (P<0.01). Logistic regression (n ¼ 96) showed that diffuse BGTH was significantly associated with requirement of high-frequency oscillation (HFO) (P ¼ 0.031), severe intraventricular hemorrhage (IVH) (P ¼ 0.004), hypotension requiring vasopressors (P ¼ 0.040), hypoglycemia (P ¼ 0.031) and male gender (P ¼ 0.014). Most patients with diffuse BGTH had normal basal ganglia and thalamus on CT/MRI, one had a hemorrhage, and one had an ischemic infarction.Conclusions: In our series, diffuse BGTH occurred in 8.3%, and was associated with factors similar to those previously reported. In contrast, several series have reported almost exclusively linear or punctuate hyperechoic foci, corresponding to hyperechogenicity of the lenticulostriate vessels. Our data provide further evidence to suggest that diffuse BGTH and hyperechogenicity of the lenticulostriate vessels are two different entities. Additional studies are required to determine the longterm significance of diffuse BGTH.

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Section: Discussionmentioning

confidence: 99%

Diffuse basal ganglia or thalamus hyperechogenicity in preterm infants

et al. 2006

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“…of our research team. 6 In these many instances, along with the congenital infections and the chromosomal abnormalities previously mentioned, a wide variety of perinatal conditions, including maternal-fetal alcohol exposure, 7 perinatal asphyxia, 8 twin-to-twin transfusion syndrome, 9 as well as other possible etiologies were thought to be related to the neurovasculopathy found in LSV. However, none of the previous studies, whether old or new, used regression modeling to control for possible confounding.…”

Section: Introductionmentioning

confidence: 99%

Association between Lenticulostriate Vasculopathy (LSV) and Neonatal Intraventricular Hemorrhage (IVH)

et al. 2004

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OBJECTIVES:To determine whether there is an unconfounded association between neonatal intraventricular hemorrhage (IVH) and lenticulostriate vasculopathy (LSV (also known as thalamostriate or mineralizing vasculopathy)). STUDY DESIGN:During the conduct of the Magnesium and Neurologic Endpoints Trial (MagNET), a randomized controlled trial involving maternal, hence fetal, exposure to antenatal magnesium sulfate in the context of preterm labor, head ultrasounds were obtained for each of the surviving neonates. Because of our previous experience in the diagnosis of LSV, when ascertaining the presence of IVH, as called for by the research protocol of our study, the presence or absence of LSV was also determined. RESULTS:We found LSV to be relatively prevalent (10% (14 of 140) among surviving babies). More importantly, it was significantly associated with the occurrence of neonatal IVH, even when controlled for possible confounding (adjusted OR 9.8, 95% confidence interval 1.3 to 73.1; p ¼ 0.03). CONCLUSION:Given the known relationships between IVH and neonatal morbidity and mortality, the finding of a statistically significant association between neonatal IVH and LSV may suggest more substantial implications for the latter than previously believed.

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“…Linear echogenic structures representing echogenic blood vessels in the thalamus and basal ganglia have been described in the fetus 1 , and in newborn infants 2,3 . These linear or branching linear areas of echogenicity have been suggested to represent calcifications 4 , or vasculopathy 4,5 .…”

Section: Discussionmentioning

confidence: 99%

“…These linear or branching linear areas of echogenicity have been suggested to represent calcifications 4 , or vasculopathy 4,5 . Different underlying diseases have been suggested, such as congenital infections (bacterial, viral, protozoal) 2,4,5 , chromosomal aberrations (trisomy 13, trisomy 21) 3-5 , asphyxia 2,3 , non-immune hydrops, and fetal alcohol syndrome 3 . However, it should be noted that the underlying pathology was not revealed in all the reported cases.…”

Section: Discussionmentioning

confidence: 99%