Linear and star-shaped poly(2-ethyl-2-oxazine)s. Synthesis, characterization and conformation in solution

Smirnova, A. V.; Kirila, Tatyana; Blokhin, A. N.; Kozina, N. D.; Kurlykin, M. P.; Теньковцев, А. В.; Филиппов, А. П.

doi:10.1016/j.eurpolymj.2021.110637

Cited by 7 publications

(3 citation statements)

References 65 publications

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“…As can be seen from Table 1 , A 0 values increased from 2.4 to 3.2 × 10 10 , erg·K −1 mol −1/3 with increasing DMAPMA content, i.e., a decrease in intramolecular density. Similar behavior was previously observed in the homologous series of star-shaped four-armed poly-2-ethyl-2-oxazine [ 40 ]. Note that low values of A 0 ≤ 2.8, i.e., lower than the theoretically predicted value for a hard sphere, are typical for polymers with complex architecture, such as molecular brushes, as well as hyperbranched and star-shaped polymers [ 41 , 42 , 43 , 44 ].…”

Section: Resultssupporting

confidence: 86%

Synthesis, Characterization, Conformation in Solution, and Thermoresponsiveness of Polymer Brushes of methoxy[oligo (propylene glycol)-block-oligo(ethylene glycol)]methacrylate and N-[3-(dimethylamino)propyl]methacrylamide Obtained via RAFT Polymerization

et al. 2023

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The thermo- and pH-responsive polymer brushes based on methoxy[oligo(propyleneglycol)8-block-oligo(ethyleneglycol)8]methacrylate with different concentrations of N-[3-(dimethylamino)propyl]methacrylamide (from 0% to 20%) were synthesized via RAFT polymerization. The “grafting-through” approach was used to prepare the low-molar-mass dispersion samples (Mw/Mn ≈ 1.3). Molar masses and hydrodynamic characteristics were obtained using static and dynamic light scattering and viscometry. The solvents used were acetonitrile, DMFA, and water. The molar masses of the prepared samples ranged from 40,000 to 60,000 g·mol–1. The macromolecules of these polymer brushes were modeled using a prolate revolution ellipsoid or a cylinder with spherical ends. In water, micelle-like aggregates were formed. Critical micelle concentrations decreased with the content of N-[3-(dimethylamino)propyl]methacrylamide. Molecular brushes demonstrated thermo- and pH-responsiveness in water–salt solutions. It was shown that at a given molecular mass and at close pH values, the increase in the number of N-[3-(dimethylamino)propyl]methacrylamide units led to an increase in phase separation temperatures.

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Section: Resultssupporting

confidence: 86%

Synthesis, Characterization, Conformation in Solution, and Thermoresponsiveness of Polymer Brushes of methoxy[oligo (propylene glycol)-block-oligo(ethylene glycol)]methacrylate and N-[3-(dimethylamino)propyl]methacrylamide Obtained via RAFT Polymerization

et al. 2023

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“…Moreover, the conformation and hydrodynamic properties of linear PEtOx and PiPrOx could be assumed identical. This conclusion is supported by the results of studies of linear and star-shaped poly(2-ethyl-2-oxazine) [54]. It was shown that a change by one -CH 2 -group of the monomer unit of pseudo-polypeptoids does not lead to a change in the conformational characteristics of the polymer.…”

Section: Hydrodynamic Characteristics and Conformation Of Star-shaped Ca8-palox-urmentioning

confidence: 66%

Features of Solution Behavior of Polymer Stars with Arms of Poly-2-alkyl-2-oxazolines Copolymers Grafted to the Upper Rim of Calix[8]arene

et al. 2021

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Star-shaped polymers with arms of block and gradient copolymers of 2-ethyl- and 2-isopropyl-2-oxazolines grafted to the upper rim of calix[8]arene were synthesized by the “grafting from” method. The ratio of 2-ethyl- and 2-isopropyl-2-oxazoline units was 1:1. Molar masses and hydrodynamic characteristics were measured using molecular hydrodynamics and optics methods in 2-nitropropane. The arms of the synthesized stars were short and the star-shaped macromolecules were characterized by compact dimensions and heightened intramolecular density. The influence of the arm structure on the conformation of star molecules was not observed. At low temperatures, the aqueous solutions of the studied stars were not molecular dispersed but individual molecules prevailed. One phase transition was detected for all solutions. The phase separation temperatures decreased with a growth of the content of more hydrophobic 2-isopropyl-2-oxazoline units. It was shown that the way of arms grafting to the calix[8]arene core affects the behavior of aqueous solutions of star-shaped poly-2-alkyl-2-oxazoline copolymers. In the case of upper rim functionalization, the shape of calix[8]arene resembles a plate. Accordingly, the core is less shielded from the solvent and the phase separation temperatures are lower than those for star-shaped poly-2-alkyl-2-oxazolines with lower rim functionalization of the calix[8]arene.

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“…Besides the possibility to design telechelic PAOx, 24 the synthesis via the cationic ring-opening polymerisation (CROP) of 2-oxazolines allows for the preparation of a wide range of side chain functionalised homo-and copolymers, [25][26][27] as well as different polymer architectures. [28][29][30] Due to the favourable low-fouling properties 31,32 and low immunogenicity of hydrophilic PAOx, [33][34][35] they possess high potential for use in the field of nanomedicines and numerous studies have already investigated their potential in this area. [36][37][38][39] PAOx with longer alkyl side chains (e.g., ethyl, n-propyl, or iso-propyl) 40,41 as well as other functional side chains such as methyl esters 42 or nitriles 43 exhibit LCST behavior.…”

Section: Introductionmentioning

confidence: 99%

Amidation of methyl ester-functionalised poly(2-oxazoline)s as a powerful tool to create dual pH- and temperature-responsive polymers as potential drug delivery systems

et al. 2023

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Linear and star-shaped poly(2-ethyl-2-oxazine)s. Synthesis, characterization and conformation in solution

Cited by 7 publications

References 65 publications

Synthesis, Characterization, Conformation in Solution, and Thermoresponsiveness of Polymer Brushes of methoxy[oligo (propylene glycol)-block-oligo(ethylene glycol)]methacrylate and N-[3-(dimethylamino)propyl]methacrylamide Obtained via RAFT Polymerization

Synthesis, Characterization, Conformation in Solution, and Thermoresponsiveness of Polymer Brushes of methoxy[oligo (propylene glycol)-block-oligo(ethylene glycol)]methacrylate and N-[3-(dimethylamino)propyl]methacrylamide Obtained via RAFT Polymerization

Features of Solution Behavior of Polymer Stars with Arms of Poly-2-alkyl-2-oxazolines Copolymers Grafted to the Upper Rim of Calix[8]arene

Amidation of methyl ester-functionalised poly(2-oxazoline)s as a powerful tool to create dual pH- and temperature-responsive polymers as potential drug delivery systems

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