Energetic-ion driven instability in a Japan Atomic Energy Research Institute Tokamak-60 Upgrade (JT-60U) [S. Ishida et al., Phys. Plasmas 11, 2532(2004] plasma was investigated using a simulation code for magnetohydrodynamics and energetic particles. The spatial profile of the unstable mode peaks near the plasma center where the safety factor profile is flat. The unstable mode is not a toroidal Alfvén eigenmode (TAE) because the spatial profile deviates from the expected location of TAE and the spatial profile consists of a single primary harmonic m / n =2/1 where m and n are poloidal and toroidal mode numbers. The real frequency of the unstable mode is close to the experimental starting frequency of the fast frequency sweeping mode. Simulation results demonstrate that energetic-ion orbit width and energetic-ion pressure significantly broaden radial profile of the unstable mode. For the smallest value among the investigated energetic-ion orbit width, the unstable mode is localized within 20% of the minor radius. This gives an upper limit of the spatial profile width of the unstable mode which the magnetohydrodynamic effects alone can induce. For the experimental condition of the JT-60U plasma, energetic ions broaden the radial width of the unstable mode spatial profile by a factor of 3. The unstable mode is primarily induced by the energetic particles.