Linear and nonlinear changes in the auditory brainstem response of aging humans

Lavoie, Brigitte; Mehta, Rajnikant; Thornton, A. R. D.

doi:10.1016/j.clinph.2007.12.004

Cited by 11 publications

(9 citation statements)

References 47 publications

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“…Furthermore, the stepwise multiple-regression analysis showed that the threshold stimulus level increased as a function of age for both peaks II and IV. Elevated ABR thresholds among geriatric monkeys in the present study are consistent with previous studies in nonhuman primates (Fowler et al 2002(Fowler et al , 2010Harada et al 1999;Lasky et al 1999;Torre et al 2004), rodents (Backoff and Caspary 1994;Boettcher 2002;McFadden et al 1997;Parthasarathy and Bartlett 2012;Parthasarathy et al 2014;Syka 2010), and humans (Demeester et al 2009;Gates and Mills 2005;Jerger and Johnson 1988;Lavoie et al 2008;Rowe 1978;Skoe et al 2013;Wiley et al 2008). At the suprathreshold level (70 dB pSPL), the amplitudes of peaks II and IV decreased, and their corresponding peak latencies increased as a function of age for clicks and tone frequencies.…”

Section: Discussionsupporting

confidence: 93%

“…Estrogen levels are known to effectively modulate hearing sensitivity in female humans and rodents (Hultcrantz et al 2006). Auditory thresholds vary with the menstrual cycle in females, and hormonal changes before and after menopause may impact audiometric measures in geriatric women Hederstierna et al 2010;Krizman et al 2012;Lavoie et al 2008;Serra et al 2003;Tandon et al 2001; Vander Werff and Burns 2011). Follow-up investigations in nonhuman primates are necessary to clarify how a variety of sex-related factors could modulate hearing sensitivity during aging.…”

Section: Sex-related Influence On Arhl In Monkeysmentioning

confidence: 94%

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Age-related changes of auditory brainstem responses in nonhuman primates

Navarro

Engle

et al. 2015

Journal of Neurophysiology

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Nonhuman primates, compared with humans and rodents, have historically been far less used for studies of age-related hearing loss, primarily because of their long life span and high cost of maintenance. Strong similarities in genetics, anatomy, and neurophysiology of the auditory nervous system between humans and monkeys, however, could provide fruitful opportunities to enhance our understanding of hearing loss. The present study used a common, noninvasive technique for testing hearing sensitivity in humans, the auditory brainstem response (ABR), to assess the hearing of 48 rhesus macaques from 6 to 35 yr of age to clicks and tone stimuli between 0.5 and 16.0 kHz. Old monkeys, particularly those above 21.5 yr of age, had missing ABR waveforms at high frequencies. Regression analyses revealed that ABR threshold increased as a function of age at peaks II and IV simultaneously. In the suprathreshold hearing condition (70 dB peak sound pressure level), ABR-based audiograms similarly varied as a function of age such that old monkeys had smaller peak amplitudes and delayed latencies at low, middle, and high frequencies. Peripheral hearing differences remained a major influence associated with age-related changes in audiometric functions of old monkeys at a comparable sensation level across animals. The present findings suggest that hearing loss occurs in old monkeys across a wide range of frequencies and that these deficits increase in severity with age. Parallel to prior studies in monkeys, we found weak effects of sex on hearing, and future investigations are necessary to clarify its role in age-related hearing loss.

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Section: Discussionsupporting

confidence: 93%

Section: Sex-related Influence On Arhl In Monkeysmentioning

confidence: 94%

Age-related changes of auditory brainstem responses in nonhuman primates

Navarro

Engle

et al. 2015

Journal of Neurophysiology

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“…Researchers have suggested that difficulties with temporal interactions or retrieval may be associated with age. Lavoie, et al, (2008)'s study assessed the changes in linear and nonlinear temporal interactions in the aging auditory brainstem of humans using maximum length sequence stimulation of 30 normal hearing females aged between 11 and 61years old. Results indicate that the linear and nonlinear components of the maximum length sequence -ABR could be more sensitive to changes occurring in the auditory system before any functionally significant changes in hearing status.…”

Section: Introductionmentioning

confidence: 99%

Effects of Auditory Brainstem Response (ABR) on Measuring Children’s Auditory Functions: An Experimental Investigation

Yaari¹,

Al-Maflehi²

2013

JSEL

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Background: Measuring hearing functional capabilities by Auditory Brainstem Responses (ABR) may contribute to better treatment, and possible differences in this process may have important clinical implications. Objectives: To measure the validity and reliability of ABR through screening, estimating, and intraoperative monitoring auditory capabilities of Arab infants and children and the degree of their seriousness.

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“…Since it became commercially available, the MLS paradigm has been studied mainly in ABR (auditory brainstem response) acquisition (Burkard et al, 1990;Marsh, 1992;Lasky, 1993;Lina-Granade et al, 1994;Leung et al, 1998;Jirsa, 2001;Delgado and Ozdamar, 2004;Dzulkarnain et al, 2008;Lavoie et al, 2008). MLS-ABR paradigms have been used to examine reductions in recording time, and auditory system response at high stimulation rates (Burkard et al, 1990;Lina-Granade et al, 1994).…”

mentioning

confidence: 99%