Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic

Navas, José M.; González-Mazo, Eduardo; Wenzel, Andrea; Gómez-Parra, Abelardo; Segner, Helmut

doi:10.1016/s0025-326x(99)00036-3

Cited by 18 publications

(8 citation statements)

References 27 publications

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“…LAS is known to be a non-cancer inducer compound (Yam et al 1984) and even though Caco-2 cells express estrogen receptors (Campbell-Thompson et al 2001), LAS and its degradation products have been reported to be not estrogenic (Navas et al 1999). Interestingly, our findings suggest that LAS at non cytotoxic concentrations and for short exposure time (24 h) increases colon cancer cells proliferation.…”

Section: Resultsmentioning

confidence: 47%

Effect of linear alkylbenzene sulfonate (LAS) on human intestinal Caco-2 cells at non cytotoxic concentrations

et al. 2015

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Linear alkylbenzene sulfonate (LAS) is a cytotoxic synthetic anionic surfactant widely present in the environment due to its large-scale production and intensive use in the detergency field. In this study, we investigated the effect of LAS (CAS No. 25155-30-0) at non cytotoxic concentrations on human intestinal Caco-2 cells using different in vitro bioassays. As results, LAS increased Caco-2 cell proliferation at concentrations ranging from 1 to 15 ppm, more significantly for shorter exposure time (24 h), confirmed using flow cytometry and trypan blue exclusion methods. Moreover, proteomics analysis revealed that this effect was associated with an over-expression of elongation factor 2 and dipeptidyl peptidase 3, and a down-regulation of 14-3-3 protein theta, confirmed at mRNA level using real-time PCR. These findings suggest that LAS at non cytotoxic concentrations, similar to those observed at wastewater treatment plants outlets, increases the growth rate of colon cancer cells, raising thereby its tumor promotion effect potential.

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Section: Resultsmentioning

confidence: 47%

Effect of linear alkylbenzene sulfonate (LAS) on human intestinal Caco-2 cells at non cytotoxic concentrations

et al. 2015

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“…Due to their similar chemical properties with the estrogenic alkylphenolpolyethoxylates, LAS and degradation metabolites could have some estrogenic activity. However, using in vitro bioassays, the yeast estrogene receptor assay and the vitellogenin assay with cultured trout hepatocytes, no estrogenicity is observed for any of the tested compounds (Navas et al 1999). The estrogenicity studies by in vivo tests, utilising Wistar female rats as test animals and the increase of uterine weight as an estrogenic factor, corroborate these results.…”

Section: Treatment Possibilitiesmentioning

confidence: 55%

Sulphonated aromatic pollutants

Schwitzguébel

Aubert

Große

et al. 2002

Environ. Sci. & Pollut. Res

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Many synthetic sulphonated aromatic compounds are used as starting material to produce dyes and pigments, or are released as by-products in the effluents of the textile and dye industry. A large number of these chemicals are poorly biodegradable and cannot be eliminated by classical wastewater treatment plants. To limit the impact of these pollutants on the environment, new processes, based on the use of higher plants (constructed wetlands or hydroponic systems), are under development. Detergents and surfactants are essential for both industrial and domestic applications, the most important family being the alkylbenzene sulphonates. Originally, the alkyl side chains were branched and thus recalcitrant to biodegradation. Therefore, they have been replaced by linear alkylbenzene sulphonates. Although more acceptable, present formulations still have adverse environmental and toxic effects. In this context, phytoremediation appears to be a promising approach to remove these compounds from contaminated soils and waters.

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“…Oxidation of LAS by oxygen results in the formation of sulfophenylcarboxylic acid (SPC) that comprises one of the main products of biodegradation [7][8][9].…”

Section: Introductionmentioning

confidence: 99%

Electrocoagulative and Biological Treatment of Laundry Wastewater

Ramcharan¹,

Bissessur²

2017

Biological Wastewater Treatment and Resource Recovery

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The greater demand for potable water, both locally and worldwide, has directed a huge interest amongst researchers to investigate the possibility of recycling and reusing wastewater from laundry run-offs. The advantage of using recycling wastewater from such sources is mainly due to the fact that these bulk volumes of wastewater are considered to be less chemically polluted in comparison to those discarded from industrial effluents and wastewater sources. Almost all laundry detergents contain surfactants, whose main function serves to remove dirt/soil from contaminated items. Thus, an analysis of the surfactant levels before and after a treatment process is important to confirm that the surfactant has in fact carried out its intended purpose. Electrocoagulative treatment of wastewater, a well-researched and well-documented clean-up process that involves the production of aluminium hydroxy species by oxidation of aluminium metal upon the application of a controlled voltage which adsorbs fine particulate matter and pollutants from the wastewater has been investigated as a clean-up application to the treatment of laundry wastewater. The use of a biological treatment process which entails treating the wastewater with aerobic bacterial specie specifically designed to degrade fats, lipids, protein, detergents and hydrocarbons has also been investigated.

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Linear Alkylbenzene Sulfonates and Intermediate Products from their Degradation are not Estrogenic

Cited by 18 publications

References 27 publications

Effect of linear alkylbenzene sulfonate (LAS) on human intestinal Caco-2 cells at non cytotoxic concentrations

Effect of linear alkylbenzene sulfonate (LAS) on human intestinal Caco-2 cells at non cytotoxic concentrations

Sulphonated aromatic pollutants

Electrocoagulative and Biological Treatment of Laundry Wastewater

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