Cell Reports volume 5, issue 1, P166-179 2013 DOI: 10.1016/j.celrep.2013.08.038 View full text
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Todd C. Metzger, Imran S. Khan, James M. Gardner, Maria L. Mouchess, Kellsey P. Johannes, Anna K. Krawisz, Katarzyna M. Skrzypczynska, Mark S. Anderson

Abstract: Thymic epithelial cells in the medulla (mTECs) play a critical role in enforcing central tolerance through expression and presentation of tissue-specific antigens (TSAs) and deletion of autoreactive thymocytes. TSA expression requires autoimmune regulator (Aire), a transcriptional activator present in a subset of mTECs characterized by high CD80 and MHC II expression and a lack of potential for differentiation or proliferation. Here, using an Aire-DTR transgenic line, we show that short-term ablation specific…

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