Todd C. Metzger, Imran S. Khan, James M. Gardner, Maria L. Mouchess, Kellsey P. Johannes, Anna K. Krawisz, Katarzyna M. Skrzypczynska, Mark S. Anderson
Thymic epithelial cells in the medulla (mTECs) play a critical role in enforcing central tolerance through expression and presentation of tissue-specific antigens (TSAs) and deletion of autoreactive thymocytes. TSA expression requires autoimmune regulator (Aire), a transcriptional activator present in a subset of mTECs characterized by high CD80 and MHC II expression and a lack of potential for differentiation or proliferation. Here, using an Aire-DTR transgenic line, we show that short-term ablation specific…
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