Lineage-negative lymphoma with a helper innate lymphoid cell phenotype

Li, Mingyang; Su, Xiaoli; Wang, Yingmei; Fan, Linni; Chai, Jia; Li, Peifeng; Zhao, Dongchi; Liu, Yixiong; Ma, Jing; Wang, Kaijing; Qu, Yan; Guo, Shuangping; Jin, Boquan; Liang, Rong; Wang, Zhe

doi:10.1007/s00428-019-02658-x

Cited by 8 publications

(8 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Immune cell infiltration was closely as0sociated with the development of breast cancer. Given that the PPPCs family was associated with immune system diseases [ 19 ] and immune system tumors [ 20 ], we analyzed whether these factors affected the immune cell infiltration of breast cancer tissues. Among the highly expressed genes in breast cancer tissues, PPP1CA was negatively correlated with CD8 + T cell and macrophage infiltration, while PPP2CA was positively correlated with infiltration.…”

Section: Resultsmentioning

confidence: 99%

Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer

et al. 2021

View full text Add to dashboard Cite

The phosphoprotein phosphatase catalytic subunit (PPPCs) family has been shown to play an important role in the development and progression of various malignancies, but its expression patterns and biological functions in breast cancer (BC) remain unclear. Therefore, we aimed to investigate the clinical significance and biological functions of the PPPCs family to understand its possible significance in the diagnosis, prognosis and treatment of breast cancer. We comprehensively investigated the expression levels, diagnostic accuracy, prognostic outcomes, biological functions and effects on immune cell infiltration of the PPPCs family in breast cancer using online databases. Except for PPP1CB, PPP1CC, PPP5C and PPEF1, the mRNA expression levels of the PPPCs family in breast cancer tissues were significantly different from those in paracancerous tissues. The differentially expressed genes (DEGs) were associated with the clinicopathological parameters and prognosis of breast cancer. The DEGs were mainly associated with the WNT signaling pathway, antigen presentation and DNA repair. In addition, the DEGs significantly affected the infiltration of immune cells in breast cancer tissues. Among the PPPCs family, PPP1CA and PPP4C played a prominent role in the progression of breast cancer, and inhibition of PPP1CA and PPP4C expression by siRNA can significantly inhibit breast cancer cells proliferation and migration. In conclusion, the PPPCs family, especially PPP1CA and PPP4C, could be used as new biomarkers to improve diagnostic accuracy, predict prognosis and novel targets for the treatment of breast cancer.

show abstract

Section: Resultsmentioning

confidence: 99%

Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer

et al. 2021

View full text Add to dashboard Cite

show abstract

“…IGLL5 located within the immunoglobulin lambda locus encoded one of the IGLLs, which were the immunoglobulin lambda joining 1 and the immunoglobulin lambda constant 1 gene segments. Only a limited number of research has shown that IGLL5 has a frequent mutation in chronic lymphocytic leukemia [33,34], lymphoma [35][36][37], and multiple myeloma [38,39]; besides, IGLL5 has a prognostic value in several diseases, such as multiple myeloma and glioblastoma [39][40][41]. Moreover, previous studies have shown that IGLL5 has a prognostic value in ccRCC, while no in-depth study has concentrated on TICs.…”

Section: Discussionmentioning

confidence: 99%

IGLL5 is correlated with tumor‐infiltrating immune cells in clear cell renal cell carcinoma

et al. 2021

View full text Add to dashboard Cite

Renal cell carcinomas (RCCs) account for about 90% of renal tumors, and their major histological subtype is ccRCC (clear cell RCC). Increasing evidence has indicated that the tumor microenvironment plays a significant role in the occurrence and development of ccRCC. In this study, we used ESTIMATE and CIBERSORT computational methods to calculate the proportion of immune and stromal components and the rate of TICs (tumor‐infiltrating immune cells) in 539 ccRCC samples from The Cancer Genome Atlas database. By examining the intersection of the differentially expressed genes obtained by the protein–protein interaction network and Cox regression analysis, we identified only one overlapping gene: IGLL5 (immunoglobulin lambda‐like polypeptide 5). We report that IGLL5 expression is correlated with TICs. Furthermore, our immunoinfiltration analyses revealed that three types of TIC are positively correlated with IGLL5 expression. IGLL5 may have potential as a prognostic biomarker of ccRCC.

show abstract

“…Previous research on IGLL5 and IL2RA focused predominantly on hematological malignancies. Fusion or mutation of IGLL5 was identified in Burkitt lymphoma, multiple lymphadenopathy, diffuse large B cell lymphoma, multiple myeloma, and chronic lymphocytic leukemia ( Kasar et al, 2015 ; White et al, 2018 ; Panea et al, 2019 ; Li et al, 2020 ; Mosquera Orgueira et al, 2021 ). It has been reported that IGLL5 may act as a risk factor and was related with metastasis and poor prognosis of multiple myeloma ( White et al, 2018 ; Barwick et al, 2019 ; D'Agostino et al, 2020 ).…”

Section: Discussionmentioning

confidence: 99%

Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma

Zheng

Xie

Cheng

et al. 2021

Front. Mol. Biosci.

View full text Add to dashboard Cite

Kidney cancer encompasses a range of primary cancers, such as clear cell renal cell carcinoma (ccRCC) and papillary renal cell carcinoma (pRCC). Our knowledge about the tumor microenvironment (TME) of kidney cancer is still limited. Therefore, we comprehensively assessed the TME of kidney cancers (including ccRCC and pRCC) using the ESTIAMTE, and CIBERSORT algorithms, and conducted distinct functional and correlation analyses with data from The Cancer Genome Atlas (TCGA), International Cancer Genome Consortium (ICGC), Gene Expression Omnibus (GEO), Connectivity map and CellMiner database. Next, we identified two immune-related hub genes, IGLL5 and IL2RA, which play essential roles in the TME as well as on survival in ccRCC and pRCC. Furthermore, ccRCC and pRCC samples from our medical center were collected to verify the clinical application value of these two immune-related genes. A specific enrichment analysis of immune cells related to IGLL5 and IL2RA was also conducted in two types of renal cell cancer. Based on selected genes, we predicted the drug response and uncovered novel drug candidate for RCC treatment. Considering the unfavorable outcomes of kidney cancer and emerging interest in TME-targeted treatments, our results may offer insights into immune-related molecular mechanisms and possible targets to control the kidney cancer.

show abstract

Lineage-negative lymphoma with a helper innate lymphoid cell phenotype

Cited by 8 publications

References 38 publications

Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer

Comprehensive analysis of PPPCs family reveals the clinical significance of PPP1CA and PPP4C in breast cancer

IGLL5 is correlated with tumor‐infiltrating immune cells in clear cell renal cell carcinoma

Integrative Analysis of Immune-Related Genes in the Tumor Microenvironment of Renal Clear Cell Carcinoma and Renal Papillary Cell Carcinoma

Contact Info

Product

Resources

About