Line‐field confocal optical coherence tomography of seborrheic keratosis: A case series

Lenoir, Clément; Pérez-Ánker, Javiera; Tognetti, Linda; Cinotti, Élisa; Trépant, Anne‐Laure; Rubegni, Pietro; Puig, Susana; Perrot, Jean‐Luc; Malvehy, Josep; Marmol, Véronique Del; Suppa, Mariano

doi:10.1111/jdv.19075

Cited by 4 publications

(4 citation statements)

References 12 publications

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“…The LC-OCT features that we observed in BCC, SCC, compound/dermal nevus, seborrheic keratosis, and pyogenic granuloma are in line with those already reported for the same lesions in other cutaneous areas. 6,7,9,16,17 In eyelid BCC (Figure 1 Based on our preliminary findings, some considerations can be made. LC-OCT is perfectly suitable for the examination of lesions of this anatomic region, as the handheld probe may be easily positioned and rapidly moved also on eyelid margin for the real-time evaluation and the image acquisition.…”

Section: Discussionmentioning

confidence: 99%

“…The LC‐OCT features that we observed in BCC, SCC, compound/dermal nevus, seborrheic keratosis, and pyogenic granuloma are in line with those already reported for the same lesions in other cutaneous areas. 6 , 7 , 9 , 16 , 17 In eyelid BCC (Figure 1 ), LC‐OCT revealed the typical diagnostic findings, including tumor basaloid islands with a laminated, “millefeuilles”, structure and dark clefting, altered dermoepidermal junction (DEJ), and prominent vessels. In eyelid SCC, LC‐OCT revealed hyperkeratosis with acanthosis, marked atypical epidermal pattern, disrupted DEJ, and tumor budding and dilated vessels in the upper dermis.…”

Section: Discussionmentioning

confidence: 99%

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Line‐field confocal optical coherence tomography of eyelid margin growths: A case series

Verzì,

Russo,

Castellino

et al. 2024

Skin Research and Technology

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BackgroundThe clinical differential diagnosis of lesions arising on the eyelid margin may be challenging and an unneeded surgical approach may have serious functional and aesthetic consequences. Nonetheless, early recognition and treatment of malignant tumors of the eyelid margin is mandatory. Line‐field confocal optical coherence tomography (LC‐OCT) is a novel tool for the in vivo, real‐time skin imaging.ObjectivesThe aim of the study was to identify and analyze the LC‐OCT features of a series of eyelid margin growths and to correlate these features with the histopathological findings.MethodsPatients with eyelid margin growths who were scheduled for lesion excision underwent LC‐OCT examination. Inclusion criteria were a challenging clinical aspect of the lesions and a clinical history of recent onset (up to 12 months). In all cases, the histopathological examination of the excised lesions was performed for the final diagnosis.ResultsA total of 31 lesions located on the upper (13 cases) or lower (18 cases) eyelid margin from 28 consecutive patients (male = 15, female = 13; mean age: 64.7 years, range: 44–87 years) were evaluated and excised. The histopathologic diagnoses were nodular basal cell carcinoma (BCC) (nine cases), squamous cell carcinoma (SCC) (three cases), compound nevus (four cases), dermal nevus (two cases), seborrheic keratosis (four cases), pyogenic granuloma (one case), trichilemmal cyst (three cases), and hidrocystoma (five cases). LC‐OCT allowed the in vivo recognition of the main microscopic features of the examined lesions.ConclusionsLC‐OCT represents a promising tool for the evaluation of eyelid margin lesions. Advantages of non‐invasive diagnosis particularly relevant in such a sensitive region include a more correct planning of the treatment and, in case of surgery, the most appropriate surgical approach and, importantly, a correct timing of intervention.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Line‐field confocal optical coherence tomography of eyelid margin growths: A case series

Verzì,

Russo,

Castellino

et al. 2024

Skin Research and Technology

View full text Add to dashboard Cite

show abstract

“…Seborrheic keratoses may mimic basal cell carcinoma, squamous cell carcinoma, actinic keratosis, verruca, and nevi, in which case a biopsy is warranted. 3 Lenoir et al 4 demonstrated the capability of LC-OCT to detect histopathology features of SK, noting the potential of LC-OCT to make in vivo diagnosis of SK without the traditional biopsy and histopathology processes. This study aims to validate the existing literature to elucidate the potential of a noninvasive tool in visualising and diagnosing SK.…”

mentioning

confidence: 99%

“…Epidermal features of SK seen with reflective confocal microscopy (RCM), such as regular honeycomb pattern, hyperkeratosis, horn cyst, and acanthosis were visualised on LC-OCT. 4,5 RCM can provide a detailed visualisation of the epidermal cells. However, as you move deeper towards the dermis utilizing RCM, cellular visualisation decreases.…”

mentioning

confidence: 99%