Line‐field confocal optical coherence tomography for the diagnosis of onychomycosis in comparison with healthy nails: A case series

Hobelsberger, Sarah; Steininger, Julian; Bauer, Andrea; Beissert, Stefan; Gellrich, Frank Friedrich

doi:10.1111/jdv.19233

Cited by 5 publications

(4 citation statements)

References 13 publications

(19 reference statements)

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“…This study examined the efficacy of LC-OCT for diagnosing onychomycosis and compared it with existing diagnostic procedures. The typical features of onychomycosis observed with LC-OCT correspond to those reported by Hobelsberger et al in their pilot case report, 21 while the obtained quantitative results are comparable with the findings reported by Rothmund et al 1 Our results confirm previous reports that PCR is an accurate method for diagnosing onychomycosis, even when other gold standard results are negative. 1,22,23 However, all gold standard methods for diagnosing onychomycosis are highly dependent on correct nail sample acquisition (e.g.…”

Section: Discussionsupporting

confidence: 92%

Line‐field confocal optical coherence tomography, a novel non‐invasive tool for the diagnosis of onychomycosis

Eijkenboom,

Daxenberger,

Gust

et al. 2024

J Deutsche Derma Gesell

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SummaryBackground and objectivesOnychomycosis is common and important to distinguish from other nail diseases. Rapid and accurate diagnosis is necessary for optimal patient treatment and outcome. Non‐invasive diagnostic tools have increasing potential for nail diseases including onychomycosis. This study evaluated line‐field confocal optical coherence tomography (LC‐OCT) as a rapid non‐invasive tool for diagnosing onychomycosis as compared to confocal laser scanning microscopy (CLSM), optical coherence tomography (OCT), and conventional methods.Patients and MethodsIn this prospective study 86 patients with clinically suspected onychomycosis and 14 controls were examined using LC‐OCT, OCT, and CLSM. KOH‐preparation, fungal culture, PCR, and histopathology were used as comparative conventional methods.ResultsLC‐OCT had the highest sensitivity and negative predictive value of all methods used, closely followed by PCR and OCT. Specificity and positive predictive value of LC‐OCT were as high as with CLSM, while OCT scored much lower. The gold standard technique, fungal culture, showed the lowest sensitivity and negative predictive value. Only PCR and culture allowed species differentiation.ConclusionsLC‐OCT enables quick and non‐invasive detection of onychomycosis, with advantages over CLSM and OCT, and similar diagnostic accuracy to PCR but lacking species differentiation. For accurate nail examination, LC‐OCT requires well‐trained and experienced operators.

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Section: Discussionsupporting

confidence: 92%

Line‐field confocal optical coherence tomography, a novel non‐invasive tool for the diagnosis of onychomycosis

Eijkenboom,

Daxenberger,

Gust

et al. 2024

J Deutsche Derma Gesell

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“…By providing a sort of "virtual biopsy", LC-OCT was able to visualize "in vivo" the main features of skin lesions closely resembling a classical histopathologic section, identifying different structures at the epidermis, DEJ, and dermis. Increasing studies in the literature report that a high LCT-OCT/histopathology correspondence of morphological substrates for both epithelial carcinomas (mainly BCC and SCC) and melanocytic lesions improves the meaning and interpretation of LC-OCT features in relation to skin tumours, hence reinforcing the utility of this new diagnostic tool [17][18][19][20][21][22][23][24][25][26][27][28].…”

Section: Discussionmentioning

confidence: 87%

“…These unprecedented technical characteristics probably explain why LC-OCT has been gaining momentum in the field of dermatological research, as over the last 5 years, numerous publications have seen the light of the day, including a large spectrum of physiological and pathological dermatological conditions. In particular, in the latter group, this tool has been successfully employed to visualize epidermal and upper dermal alterations of tumoral, inflammatory, autoimmune, vascular, and infective conditions and diseases, and also in a pediatric population [17][18][19][20][21][22][23][24][25][26][27][28]. Skin manifestations of rare genetic disorders have also been assessed [26].…”

Section: Introductionmentioning

confidence: 99%

Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions

Di Stefani,

Cappilli,

Cuffaro

et al. 2023

Diagnostics

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Background: Periocular malignancies may be clinically different from the examples arising at other sites, with possible delayed diagnosis and greater challenges for treatment and repair. Line-field confocal optical coherence tomography (LC-OCT) is a recently developed technique characterized by an unprecedented capacity to acquire high-definition images in vertical and horizontal modes. In this study, we aimed to investigate the LC-OCT morphological features of a series of eyelid skin lesions, correlating them to histopathological findings. Methods: Patients with biopsy-proven equivocal skin lesion in the eyelid area, previously investigated by means of LC-OCT, were included in the study. Percentage overall agreement was estimated for LC-OCT and histopathological diagnosis for study cases. Results: A total of 51 patients (28 women, 23 men; mean age 66.4 years old), for a total of 51 skin lesions, were assessed. The histopathological diagnosis consisted of 30 malignant and 21 benign tumors. Different entities were characterized by peculiar findings in LC-OCT, alike to histopathological features, allowing for an accurate “in vivo” classification in almost all cases, with a diagnostic concordance with histopathology of 92.1% (47/51). Conclusions: By integrating this new imaging technique into the assessment of suspicious tumors in this area, diagnostic accuracy may increase, improving strategies adopted in multidisciplinary meetings and patient-centered care.

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“…Recent studies and case reports have shown that LC-OCT is a valuable tool fo nosing various inflammatory and infectious skin conditions, focusing on architectu teria such as fluid accumulation, changes in epidermal layers, the shape of the D cular architecture, the presence of inflammatory infiltrates, and the detection of bodies [49][50][51][52][53]. Figure 10 shows some of the LC-OCT detection criteria of psorias stratum corneum shows hyperkeratosis.…”

Section: Inflammatory and Infectious Skin Diseasesmentioning

confidence: 99%

Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Skin Imaging in Dermatology

Latriglia,

Ogien,

Tavernier

et al. 2023

Life

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Line-field confocal optical coherence tomography (LC-OCT) is a non-invasive optical imaging technique based on a combination of the principles of optical coherence tomography and reflectance confocal microscopy with line-field illumination, which can generate cell-resolved images of the skin in vivo. This article reports on the LC-OCT technique and its application in dermatology. The principle of the technique is described, and the latest technological innovations are presented. The technology has been miniaturized to fit within an ergonomic handheld probe, allowing for the easy access of any skin area on the body. The performance of the LC-OCT device in terms of resolution, field of view, and acquisition speed is reported. The use of LC-OCT in dermatology for the non-invasive detection, characterization, and therapeutic follow-up of various skin pathologies is discussed. Benign and malignant melanocytic lesions, non-melanocytic skin tumors, such as basal cell carcinoma, squamous cell carcinoma and actinic keratosis, and inflammatory and infectious skin conditions are considered. Dedicated deep learning algorithms have been developed for assisting in the analysis of LC-OCT images of skin lesions.

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Line‐field confocal optical coherence tomography for the diagnosis of onychomycosis in comparison with healthy nails: A case series

Cited by 5 publications

References 13 publications

Line‐field confocal optical coherence tomography, a novel non‐invasive tool for the diagnosis of onychomycosis

Line‐field confocal optical coherence tomography, a novel non‐invasive tool for the diagnosis of onychomycosis

Line-Field Confocal Optical Coherence Tomography Evaluation of Eyelid Skin Lesions

Line-Field Confocal Optical Coherence Tomography (LC-OCT) for Skin Imaging in Dermatology

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