Lindane may modulate the female reproductive development through the interaction with ER-β: an in vivo–in vitro approach

Maranghi, Francesca; Rescia, Michele; Macrı̀, Caterina; Consiglio, Emma Di; Angelis, Gabriele De; Testai, Emanuela; Farini, Donatella; Felici, Massimo De; Lorenzetti, Stefano; Mantovani, Alberto

doi:10.1016/j.cbi.2007.04.008

Cited by 48 publications

(27 citation statements)

References 59 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The animals were divided into 6 groups with 6 (10 mg/kg body weight). After 30 days of treatment period, the animals were deprived of food overnight and anesthetized and then sacrificed by cervical decapitation.…”

Section: Methodsmentioning

confidence: 99%

“…Lindane (100mg/kg) dissolved in 0.3 mL of olive oil and Quercetin (10 mg/kg) dissolved in 0.3 mL of 50% ethanol were administered to rats orally for 30 days. Where animals received co-treatment with lindane and quercetin, lindane was administered first followed by quercetin with about 15 minutes gap between the treatments.…”

Section: Treatment Schedulementioning

confidence: 99%

“…Lindane's insecticidal activity is ascribed to neuroexcitation subsequent to inhibition of GABA channels [7][8][9] . Lindane inhibits uterine contractions by inhibiting myometrial gap junction permeability [10] . Lindane (VLDL) and tissue triglycerides, cholesterol with concomitant decrease in serum HDL and tissue phospholipids were decreased in lindane treated rats were found to be significantly decreased in the quercetin and lindane co-treated rats.…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats

Padma

Lalitha

Shirony³

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

Section: Methodsmentioning

confidence: 99%

Section: Treatment Schedulementioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats

Padma

Lalitha

Shirony³

et al. 2012

Asian Pacific Journal of Tropical Biomedicine

View full text Add to dashboard Cite

“…Experimental toxicology studies provide an ample range of examples. Lindane, a persistent chlorinated compound widely use in the past as insecticide, does alter the female reproductive development through the interaction with ER-beta [35]; lindane also reduces spematogenesis in male mice exposed in utero, an effect which might be related to an enhanced, CYP-mediated testosterone catabolism [36], suggesting a sex-related differential mechanism. The widespread neurotoxic insecticide chlorpyrifos acts as an ED in rodents only when exposure does occure in utero: the adult offspring of mouse dams exposed to non-neurotoxic dose levels show alterations of oxytocin and vasopressin brain levels [37] as well as of thyroid hormone balance [38], more pronounced in males.…”

Section: Different Stages Of Lifementioning

confidence: 99%

Endocrine Disrupters and Food Safety

Mantovani¹

2015

TOBIOTJ

Self Cite

View full text Add to dashboard Cite

The general population is constantly exposed to a mixture of endocrine disrupters (ED), mainly through the food chain.The dietary exposure pathways are diverse, since ED can: i) affect diet components most liable to environmental pollution (e.g., polychlorinated and polybrominated chemicals in lipid-rich foods); ii) be employed in food production (e.g., certain groups of agrochemicals); iii) be released from food contact materials or during food production processes (such as bisphenol A or phthalates); iv) last but not least, be naturally present in food: endocrineactive nutrients and bioactive substances, such as iodine and phytoestrogens, respectively, may elicit health risks when intakes are excessive. Main health concerns from dietary exposure to ED include the building-up of a pollutants body burden and the potential for additive, "cocktail" effects.The factors modulting exposure and susceptibility are considered, including different stages of life, the modulation of risks by dietary habits and the multiple, often inadequately understood, interactions between ED and food components.

show abstract

“…The organophosphorus insecticide chlorpyrifos acts as an ED in rodents only when exposure occurs in utero; the adult offspring of mouse dams exposed to nonneurotoxic dose levels show sex-dimorphic neuroendocrine alterations in specific brain regions concerning estrogen receptor-β, oxytocin and vasopressin [46,47]. In other instances, sex-related differential mechanisms can occur; the delayed developmental effect elicited by the chlorinated insecticide lindane on the reproductive tracts in adult mouse offspring are mediated through estrogen receptor-β or interference with testosterone catabolism in females and males, respectively [48,49]. These few examples indicate the great relevance of effects upon intrauterine exposure for the risk assessment of ED.…”

Section: Factors Modulating the Ed-associated Health Risks: Life Stagmentioning

confidence: 99%

Endocrine Disrupters and the Safety of Food Chains

Mantovani¹

2015

Horm Res Paediatr

Self Cite

View full text Add to dashboard Cite

Endocrine disrupters (ED) are a heterogeneous group of chemicals including persistent contaminants, pesticides, as well as compounds present in consumer products and natural substances. For most ED, the food chain is a current major exposure route for the general population. ED can enter the food chain through the living environment (e.g., feeds, fertilizers) of food-producing organisms, be directly employed in food production (e.g., pesticides) or be released from food contact materials (such as bisphenol A or phthalates); in addition, the endocrine disruption potential of some natural compounds in edible plants, including the so-called phytoestrogens, should not be overlooked. An exposure assessment has to consider the specific liability of food commodities to contamination with specific ED (e.g., polychlorinated and polybrominated chemicals in lipid-rich foods). The paper discusses the main toxicological research issues in order to support the risk assessment of ED in food chains, including: the potential for additive, ‘cocktail' effects (as from multiple pesticide residues); the long-term effects on target body systems (e.g., reproductive, nervous) elicited by exposure during prenatal as well as postnatal life stage windows, and toxicant/nutrient interactions (e.g., thyroid-targeting ED and iodine status). Food safety systems should exploit the available knowledge to improve prevention of long-term risks along the whole food chain.

show abstract

Lindane may modulate the female reproductive development through the interaction with ER-β: an in vivo–in vitro approach

Cited by 48 publications

References 59 publications

Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats

Effect of quercetin against lindane induced alterations in the serum and hepatic tissue lipids in wistar rats

Endocrine Disrupters and Food Safety

Endocrine Disrupters and the Safety of Food Chains

Contact Info

Product

Resources

About