Lindane and Hematologic Reactions

West, Irma

doi:10.1080/00039896.1967.10664883

Cited by 47 publications

(13 citation statements)

References 20 publications

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“…Most importantly, evidence is provided that ERa trigger the in vivo pro-angiogenic effects of lindane and chlordecone inasmuch their effets are prevented after silencing of ERa. Several epidemiological studies have been conducted until the early eighty's on the toxicity of lindane [26,27] and chlordecone [28,29] in humans. Indeed, it was reported that lindane, chlordecone and their metabolites are stored in the blood [30], adipose tissue, prostate [7], breast [31] explaining the influence of these chemicals on tumor development and obesity, two pathophysiological situations in which angiogenesis plays an important role [32].…”

Section: Discussionmentioning

confidence: 99%

Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis

et al. 2012

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Epidemiological studies report that exposure to pesticides like chlordecone and lindane increases risk of cancer. They may act as endocrine disruptors via the activation of estrogen receptor α (ERα). Carcinogenesis involved angiogenesis and no available data regarding these organochlorines have been reported. The present study aimed at investigating the effects of lindane and chlordecone on cellular processes leading to angiogenesis through an involvement of ERα. Angiogenesis has been analyzed both in vitro, on human endothelial cells, and in vivo by quantifying neovascularization with the use of ECMgel® plug in mice. Both pesticides increased endothelial cell proliferation, migration and MMP2 activity. These toxics potentiated cell adhesion by enhancing FAK phosphorylation and stress fibers. The two organochlorines increased nitric oxide production via an enhancement of eNOS activity without modification of oxidative stress. Evidence has been provided that the two toxins increased in vivo neovascularization. Most interestingly, all the above processes were either partially or completely prevented after silencing of ERα. Altogether, these data highlight that organochlorines modulate cellular angiogenic processes through activation of ERα. This study further reinforces the harmful effects of these pesticides in carcinogenesis, particularly in the modulation of angiogenesis, a critical step in tumor promotion, through ERα.

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Section: Discussionmentioning

confidence: 99%

Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis

et al. 2012

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“…54 Individual pesticides have been implicated in disease causation, including, particularly, the chlorinated hydrocarbons, organophosphates, chlorophenols, and pyrethins. [56][57][58][59] Agricultural carbamates have not been associated previously with AA. We reported a possible association with household insecticides in this class from phase 1 of the present study 31 that was not observed in the phase 2 data.…”

Section: Discussionmentioning

confidence: 99%

The epidemiology of aplastic anemia in Thailand

Issaragrisil

Kaufman

Anderson

et al. 2006

Blood

161

113

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Aplastic anemia has been linked to environmental exposures, from chemicals and medical drugs to infectious agents. The disease occurs more frequently in Asia than in the West, with incidence rates 2-to 3-fold higher. We report updated results of an epidemiologic study conducted in Thailand from 1989 to 2002, in which 541 patients and 2261 controls were enrolled. Exposures were determined by in-person interview. We observed significantly elevated relative risk estimates for benzene (3.5) and other solvents (2.0) and for sulfonamides (5.6), thiazides (3.8), and mebendazole (3.0). Chloramphenicol use was infrequent, and no significant association was observed. Agricultural pesticides were implicated in Khonkaen (northeastern Thailand). There were significant associations with organophosphates (2.1), DDT (6.7), and carbamates (7.4). We found significant risks for farmers exposed to ducks and geese (3.7) and a borderline association with animal fertilizer (2.1). There was a significant association in Khonkaen with drinking other than bottled or distilled water (2.8).

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“…After lindane and toxaphen-exposure, a patient suffered fl'om aplastic anaemia preceding myelomonocytic leukaemia [20,22]. A correlation between HCH, usually lindane exposure, and the onset of aplastic anaemia with acute myelogenous leukaemia has been repeatedly claimed [14,31,32]. Aksoy et al [1][2][3] in Turkey and Vigliani and co-workers in Italy [28][29][30] found a statistical correlation between myelogenous, monocytic, erythrocytic, and lymphocytic leukaemia, as well as aplastic anaemia, pancytopenia, lymphoma, Hodgkin disease, plasmocytoma and occupational exposure to benzene in shoe production and painting.…”

Section: Discussionmentioning

confidence: 99%

Chlorinated hydrocarbons in the bone Marrow of children: Studies on their association with leukaemia

1992

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Concentrations of chlorinated hydrocarbons and polychlorinated biphenyls (PCB) were determined by capillary column gas chromatography in samples of bone marrow from 38 children with leukaemia (16 samples/pools) and 15 control (5 pools). The highest mean and median concentrations were detected for total PCB (mean = 3.568 mg/kg fat basis/median 2.904 mg/kg) followed by the sum of the dichlorodiphenyltrichloroethane metabolites (1.775/1.059 mg/kg), hexachlorobenzene 0.354/0.260 mg/kg), the sum of the hexachlorocyclohexane isomers (0.133/0.093 mg/kg) and dieldrin (0.109/0.063 mg/kg). The CHC and PCB concentrations in bone marrow were two- to threefold higher than in fat tissue. Comparing children with and without leukaemia similar concentrations of CHC and PCB were found.

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Lindane and Hematologic Reactions

Cited by 47 publications

References 20 publications

Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis

Estrogen receptor alpha as a key target of organochlorines to promote angiogenesis

The epidemiology of aplastic anemia in Thailand

Chlorinated hydrocarbons in the bone Marrow of children: Studies on their association with leukaemia

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