lincRNA-RP11400K9.4 Regulates Cell Survival and Migration of Breast Cancer Cells

Fernández-Rojas, Miguel A; Meléndez-Zajgla, Jorge; Lagunas, Vilma Maldonado

doi:10.21873/cgp.20231

Cited by 2 publications

(1 citation statement)

References 31 publications

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“…Long noncoding RNAs (lncRNAs) are a series of transcripts longer than 200 nucleotides that have limited protein coding capability [3][4][5]. Several studies have reported that the deregulation of lncR-NAs, such as LncRNA RP11-400K9.4 [6], lncRNA DILA1 [7], and LncRNA OIP5-AS1 [8] affects the tumorigenesis and progression of breast invasive carcinoma (BRCA). However, the detailed mechanism underlying the regulation and alteration of these lncRNAs in BRCA over time remains unknown.…”

Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of RNA-Binding Protein-Related lncRNA in Breast Invasive Carcinoma

Zhao¹,

Guo²,

Hou³

et al. 2023

Front. Biosci. (Landmark Ed)

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Background: RNA-binding proteins (RBPs), which form complexes or single/multiple RNA-binding domains, have a functional role in regulating and determining the function or stability of the bound RNAs in various cancers, including breast invasive carcinoma (BRCA). However, the biological functions and clinical implications of RBP-related long noncoding RNAs (lncRNAs) in BRCA remain largely unknown. Methods: Herein, we first identified and characterized RBP-related lncRNAs in BRCA. Then we built an RBP-related lncRNA signature (RBPLSig) and explored the clinical evaluation and prediction performance of the RBPLSig by bioinformatic analysis. In addition, to optimize treatment plans, prediction online tools was developed to predict the patient survival rate. Lastly, to verify the function of lncRNA WAC antisense RNA 1 (WAC-AS1), the experiments such as Quantitative real-time PCR (qRT-PCR), lncRNA knockdown, CCK-8, and terminal deoxynucleotidyl transferase-mediated dUTP nick-end labeling (TUNEL) staining were performed. We also gained the potential mechanisms of the druggable compounds of the WAC-AS1 related RBP gene, putative NSUN6, using molecular docking. Results: The results showed that RBPLSig, as an independent prognostic factor for BRCA patients, was involved in numerous malignancy-associated immunoregulatory pathways. We found different immune statuses and responses to immunotherapy, chemotherapy, and targeted therapy between the high-and low-risk groups stratified by RBPLSig. Conclusions: Our data broaden the comprehensive understanding of the biological functions of RBP-related lncRNAs, and demonstrate a novel and independent RBPLSig to assess prognosis and the immune microenvironment, thus helping to guide treatment decisions for BRCA.

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Section: Introductionmentioning

confidence: 99%

Comprehensive Analysis of RNA-Binding Protein-Related lncRNA in Breast Invasive Carcinoma

Zhao¹,

Guo²,

Hou³

et al. 2023

Front. Biosci. (Landmark Ed)

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The Role of Hypoxia-Associated Long Non-Coding RNAs in Breast Cancer

Maldonado

Meléndez-Zajgla

2022

Cells

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Breast cancer is the leading cause of cancer-related deaths in women worldwide. In the United States, even with earlier diagnosis and treatment improvements, the decline in mortality has stagnated in recent years. More research is needed to provide better diagnostic, prognostic, and therapeutic tools for these patients. Long non-coding RNAs are newly described molecules that have extensive roles in breast cancer. Emerging reports have shown that there is a strong link between these RNAs and the hypoxic response of breast cancer cells, which may be an important factor for enhanced tumoral progression. In this review, we summarize the role of hypoxia-associated lncRNAs in the classic cancer hallmarks, describing their effects on the upstream and downstream hypoxia signaling pathway and the use of them as diagnostic and prognostic tools.

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lincRNA-RP11400K9.4 Regulates Cell Survival and Migration of Breast Cancer Cells

Cited by 2 publications

References 31 publications

Comprehensive Analysis of RNA-Binding Protein-Related lncRNA in Breast Invasive Carcinoma

Comprehensive Analysis of RNA-Binding Protein-Related lncRNA in Breast Invasive Carcinoma

The Role of Hypoxia-Associated Long Non-Coding RNAs in Breast Cancer

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