LincRNa-p21: function and mechanism in cancer

Chen, Shaoyun; Liang, Heng; Yang, Hui; Zhou, Kairu; Xu, Leilei; Liu, Jiaxian; Lai, Bei; Song, Li; Luo, Hao; Jianming, Peng; Liu, Zhidong; Xiao, Yongmei; Chen, Wen; Tang, Huanwen

doi:10.1007/s12032-017-0959-5

Cited by 75 publications

(64 citation statements)

References 53 publications

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“…However, few studies report the influence of lincRNa-p21 on CRC. In addition, further studies revealed that lincRNA-p21 was associated with malignancy progression, and contributed to the treatment and prognosis of the tumor (18,37,38). The results of the present study indicated that the relative expression of lincRNA-p21 was significantly associated with adjuvant therapy in the CRC tissue.…”

Section: Lncrna-rorsupporting

confidence: 57%

“…ROR expression suppresses p53 to maintain cellular homeostasis (17). Cyclin-dependent kinase inhibitor 1 (CDKN1A), also known as p21, mediates p53-dependent growth arrest (18). LincRNA-p21 is induced by p53 and is expressed ~15 kb upstream of the CDKN1A (p21) on chromosome 17 (15).…”

Section: Association Of Lncrna-p53 Regulatory Network (Lincrna-p21 Lmentioning

confidence: 99%

“…With regard to the function of MALAT1 in specific cells, the present study hypothesized that an interaction between MALAT1 and p53 exists in colorectal neoplasms. Previous studies have assessed the expression of lincRNA-p21 with various types of cancer (18,35,36). However, few studies report the influence of lincRNa-p21 on CRC.…”

Section: Lncrna-rormentioning

confidence: 99%

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Association of lncRNA‑p53 regulatory network (lincRNA‑p21, lincRNA‑ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors

et al. 2020

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Colorectal cancer (CRC) is a common intestinal cancer with a high mortality rate. Early detection of this type of cancer is fundamental to the prevention of the disease, which results in improved survival rates. In the human colon tissue, transition from normal epithelium to adenoma is considered to be caused by unknown molecular incidents occurring over 5-10 years. The detection of CRC has proved problematic when in the early stages of disease. In addition, identifying suitable biomarkers for the detection of CRC progress in patients remains one of the most significant challenges. Long non-coding RNAs have been demonstrated to contribute to the promotion of CRC. The aim of the present study was to investigate the clinical and biological significance of long intergenic non-coding (linc)RNA-p21, lincRNA-regulator of reprogramming (ROR) and metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) in the colon tumor and polyp tissue, and the association that these have with the expression of p53 at the mRNA level. Neoplastic and paired adjacent normal tissue samples were obtained from 72 patients (46 polyps and 26 tumors). Reverse transcription-quantitative PCR was performed to determine the relative fold changes in the expression of lincRNA-p21, lincRNA-RoR, MALAT1 and p53 in the samples. A significant association was observed between the levels of MALAT1 and p53 in neoplasm tissues (R=0.073; P<0.05). The relative expression of the MALAT1 gene revealed a statistically significant difference between the different polyp types and number of polyps (P=0.0028 and 0.022, respectively). Adjuvant therapy in patients with tumors revealed an association between the levels of lincRNA-ROR and lincRNA-p21 expression (P=0.015 and 0.038, respectively). MALAT1 may be selected as an early detection biomarker for CRC. Furthermore, lincRNA-ROR and lincRNA-p21 may serve as prognostic and therapeutic biomarkers in patients with CRC.

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Section: Lncrna-rorsupporting

confidence: 57%

Section: Association Of Lncrna-p53 Regulatory Network (Lincrna-p21 Lmentioning

confidence: 99%

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Association of lncRNA‑p53 regulatory network (lincRNA‑p21, lincRNA‑ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors

et al. 2020

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“…In recent years, with the development of high-throughput sequencing and novel computational approaches, lncRNAs have been identified as a significant player in the regulation of gene expression at the post-transcriptional level. Accordingly, there is growing evidence that the lncRNAs served as competing endogenous RNA (ceRNAs) to inhibit the expression or activity of microRNA (miRNA) (11,12). Since miRNA have been largely reported to regulate gene expression, investigating the crosstalk between lncRNAs and miRNA may enable us to better understand the mechanisms underlying the occurrence and development of associated diseases.…”

Section: Introductionmentioning

confidence: 99%

lncRNA-MIAT regulates cell biological behaviors in gastric cancer through a mechanism involving the miR-29a-3p/HDAC4 axis

Wang

Yin

et al. 2017

Oncol Rep

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Gastric cancer (GC) is one of the most common malignant diseases worldwide. Although significant progress has been made in the early detection and treatment of GC over the past decades, the prognosis is still not satisfactory and the underlying mechanisms of carcinogenesis remain unknown. Long non-coding RNA MIAT has been established as a key player in the regulation of various biological and pathological processes including chronic lymphocytic leukemias, acute myocardial infarction and neuroendocrine prostate cancer. However, the function of MIAT in GC remains largely unknown. The expressions of lncRNA MIAT, miR-29a-3p and HDAC4 mRNA were analysed using quantitative real-time PCR (qRT-PCR). RNA interference approach was used to investigate the cellular functions of MIAT and miR-29a-3p. Cell Counting Kit-8 (CCK-8) assay and flow cytometry assay were performed to detect cell proliferation and apoptosis. Cell migration and invasion abilities were evaluated by Transwell assays. In the present study, we first confirmed the high expression level of MIAT in GC tissues and cell lines. In addition, knockdown of MIAT suppressed the proliferation, migration and invasion of GC cells in vitro. Furthermore, our results demonstrated that MIAT competitively binds to miR-29a-3p and consequently upregulates the expression of HDAC4, which is a downstream target of miR-29a-3p. In conclusion, the present study highlighted the involvement of the MIAT/miR-29a-3p/HDAC4 axis in the development of GC, which provided potential diagnostic and therapeutic targets for GC.

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“…One of themost famous cis-acting element is lncRNAs X-inactivation-specifictranscript (Xist), which recruits polycomb repressive complex 2 (PRC2) leading to H3 acetylation and methylation, further inducing silence of whole X-chromosome [19, 20]. Recent study showed that long intergenic noncoding RNA p21 (lincRNA-p21) mediated p53 downstream gene [21]. The regulation of lincRNA-p21 belonged to hnRNP-K protein dependent transcriptional silencing and play a negative role in hindering expression of p53 downstream gene [22].…”

Section: Regulation Effect Of Lncrnasmentioning

confidence: 99%

The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer

Sun¹,

Wang²,

Chen³

et al. 2018

Cell Physiol Biochem

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Colorectal cancer (CRC) is one of the most common malignancies in the world. Easier recurrence and metastasis is the main cause of mortality in CRC patients, and the markers applied for diagnosis and treatment of CRC is still urgently needed to early diagnose and evaluate therapeutic effect. Long noncoding RNA (lncRNA) is a class of noncoding RNA that the length is more than 200 nucleotides. With the development of sequencing technique about transcriptome, increasing lncRNAs are focused on their function and mechanism related to the nosogenesis and pathology of CRC. Recent studies report that lncRNAs acted as crucial role in CRC and could be as biomarker for CRC diagnosis and treatment. In this review, we display the regulation of lncRNA by interacting with DNA, RNA and protein and highlight the double role of lncRNAs as oncogene or anti-tumor gene involved in Wnt signaling pathway, p53 signaling pathway or others to be an regulator in CRC development. Lastly, we discuss some new finding of lncRNAs, especially lncRNA in exosome, which could be as potential markers for diagnosis and treatment of CRC in future.

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LincRNa-p21: function and mechanism in cancer

Cited by 75 publications

References 53 publications

Association of lncRNA‑p53 regulatory network (lincRNA‑p21, lincRNA‑ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors

Association of lncRNA‑p53 regulatory network (lincRNA‑p21, lincRNA‑ROR and MALAT1) and p53 with the clinicopathological features of colorectal primary lesions and tumors

lncRNA-MIAT regulates cell biological behaviors in gastric cancer through a mechanism involving the miR-29a-3p/HDAC4 axis

The Biological Effect and Clinical Application of Long Noncoding RNAs in Colorectal Cancer

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