Lincp21-RNA as Predictive Response Marker for Preoperative Chemoradiotherapy in Rectal Cancer

Benítez, José Carlos; Campayo, Marc; Díaz, Tania; Ferrer, Carme; Acosta-Plasencia, Melissa; Monzó, Mariano; Cirera, Luis; Besse, Benjamin; Navarro, Alfons

doi:10.3390/jpm11050420

Cited by 7 publications

(5 citation statements)

References 35 publications

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“…Recent studies found that lincRNA-p21 can inhibit bladder cancer proliferation by negatively regulating glutaminase, glutamate, and α-ketoglutarate expression ( Benitez et al, 2021 ; Scholda et al, 2023 ). Overexpression of glutaminase rescued inhibitory nature of lincRNA-p21 on bladder cancer survival.…”

Section: Non-coding Rna and Mitochondrial Metabolismmentioning

confidence: 99%

Non-coding RNA and reprogrammed mitochondrial metabolism in genitourinary cancer

Thirunavukkarasu,

Banerjee,

Tantray

et al. 2024

Front. Genet.

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Non-coding ribonucleic acids (ncRNAs) have been recently shown to contribute to tumorigenesis by mediating changes in metabolism. ncRNAs act as key molecules in metabolic pathways regulation. The dysregulation of ncRNAs during cancer progression contributes to altered metabolic phenotypes leading to reprogrammed metabolism. Since ncRNAs affect different tumor processes by regulating mitochondrial dynamics and metabolism, in the future ncRNAs can be exploited in disease detection, diagnosis, treatment, and resistance. The purpose of this review is to highlight the role of ncRNAs in mitochondrial metabolic reprogramming and to relate their therapeutic potential in the management of genitourinary cancer.

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Section: Non-coding Rna and Mitochondrial Metabolismmentioning

confidence: 99%

Non-coding RNA and reprogrammed mitochondrial metabolism in genitourinary cancer

Thirunavukkarasu,

Banerjee,

Tantray

et al. 2024

Front. Genet.

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“…Long noncoding RNA (lncRNA) is a special type of RNA that is >200 nucleotides in length and does not directly code for proteins. Long intergenic noncoding RNA is a subtype of lncRNA [64]. lncRNA has recently attracted the attention of researchers, as progress in technology has allowed a more comprehensive understanding of molecular biology.…”

Section: Long Noncoding Rna (Lncrna)mentioning

confidence: 99%

“…Furthermore, they showed that overexpression of LINC00909 contributed to resistance to radiation and 5-FU in vitro and in vivo and was therefore suggested as a potential novel target that could strengthen the response to nCRT. More recently, Benitez et al [64] Table 3. miRNA biomarkers investigated for their ability to predict radiation-based therapy responses in RC patients.…”

Section: Long Noncoding Rna (Lncrna)mentioning

confidence: 99%

Biomarkers for Predicting the Response to Radiation-Based Neoadjuvant Therapy in Rectal Cancer

Chen¹,

Yang²,

Chen³

et al. 2022

Front. Biosci. (Landmark Ed)

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Locally advanced rectal cancer (RC) is treated with neoadjuvant chemoradiotherapy (nCRT) followed by radical surgery. Currently, organ-sparing approaches and/or "watch-and-wait" strategies other than unnecessary surgery have been suggested as the best option for patients who achieve complete regression after neoadjuvant treatment. However, patients respond differently to nCRT, hence the urgent need for effective methods to predict whether individual rectal cancer patients could benefit from this treatment. In this review, we summarize the biomarkers reported to be potential predictors of the therapeutic response of RC to nCRT. Biomarkers that are associated with genes, ribonucleic acid (RNA) and proteins are summarized and described first, followed by other types including immune and tumour microenvironment-related biomarkers, imaging biomarkers, microbiome-associated biomarkers, and blood-based biomarkers.

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“…For instance, Ferrando et al 24 screened three effective lncRNAs to predict NCRT response in LARC patients. Benitez et al 25 identified the Lincp21-RNA to be associated with NCRT response in LARC patients. However, there are only limited studies on lncRNAs associated with NCRT resistance.…”

Section: Introductionmentioning

confidence: 99%

LncRNAs Associated with Chemoradiotherapy Response and Prognosis in Locally Advanced Rectal Cancer

Zhang

Guan

et al. 2021

JIR

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Background There are only limited studies on the long non-coding RNAs (lncRNAs) associated with neoadjuvant chemoradiotherapy (NCRT) response and prognosis of locally advanced rectal cancer (LARC) patients. This study identified lncRNAs associated with NCRT response and prognosis in CRC patients and explored their potential predictive mechanisms. Methods The study subjected the LncRNA expression profiles from our previous gene chip data to LASSO and identified a four-lncRNA signature that predicted NCRT response and prognosis. A Cox regression model was subsequently performed to identify the prognostic risk factors. The function of LINC00909, the lncRNA with the most powerful predictive ability, was finally identified in vivo and in vitro using CRC cell lines. Results A comparison of the relative lncRNA expression of NCRT-responsive and non-responsive patients revealed four hub lncRNAs: DBET, LINC00909, FLJ33534, and HSD52 with AUC = 0.68, 0.73, 0.73, and 0.70, respectively (all p < 0.05). COX regression analysis further demonstrated that DBET, LINC00909 and FLJ33534 were associated with the DFS in CRC patients. The expression of the four lncRNAs was also significant in LARC patients who had not undergone NCRT (all p < 0.05). A risk score model was subsequently constructed based on the results of the multivariate COX analysis and used to predict NCRT response and prognosis in the CRC and LARC patients. The expression and prognosis of DBET, LINC00909 and FLJ33534 in the CRC tissues were further validated in the R2 platform and Oncomine database. Notably, overexpression of the LINC00909 increased the cell line resistance to the 5-FU and radiotherapy in vivo and in vitro. Conclusion DBET, LINC00909, and FLJ33534 are potential novel biomarkers for predicting NCRT response and prognosis in CRC patients. In particular, LINC00909 is an effective oncogene in CRC that could be used as a novel therapeutic target to enhance NCRT response.

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Lincp21-RNA as Predictive Response Marker for Preoperative Chemoradiotherapy in Rectal Cancer

Cited by 7 publications

References 35 publications

Non-coding RNA and reprogrammed mitochondrial metabolism in genitourinary cancer

Non-coding RNA and reprogrammed mitochondrial metabolism in genitourinary cancer

Biomarkers for Predicting the Response to Radiation-Based Neoadjuvant Therapy in Rectal Cancer

LncRNAs Associated with Chemoradiotherapy Response and Prognosis in Locally Advanced Rectal Cancer

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