Lincomycin and clindamycin: Their role in chemotherapy of anaerobic and microaerophilic infections

Spirocyclic Nucleosides in Medicinal Chemistry: An Overview

“…are known to inhibit the biosynthesis of peptidoglycan layer by inhibiting the phospho-MurNAc-pentapeptide translocase [28]. Till date, Ramoplanin (38) is the only clinically used antibiotic which is known to inhibit the GlcNAc transferase [29].…”

“…The lincomycin (25), obtained by fermentation of Streptomyces lincolnensis and its semi synthetic derivative clindamycin (26), were successfully used in clinics as oral antibiotics [38]. The mode of action of lincosamine involves binding to the ribosome and inhibiting bacterial protein synthesis.…”

“…Ramoplanin (38), the major component of the lipopeptide antibiotics is known to inhibit the cell wall synthesis in bacteria by forming U-shaped structures that are able to bind and capture Lipid II (C35-MurNAc-peptide-GlcNAc), a specific intermediate in membrane formation [43]. Oscient Pharmaceuticals is evaluating orally active doses of 38 in Phase-II trials against Clostridium difficile associated GI tract infections [44].…”