LINC01410/miR-23c/CHD7 functions as a ceRNA network to affect the prognosis of patients with endometrial cancer and strengthen the malignant properties of endometrial cancer cells

Lü, Ming; Ding, Ning; Zhuang, Shichao; Li, Yujiao

doi:10.1007/s11010-020-03723-9

Cited by 21 publications

(14 citation statements)

References 29 publications

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“…2,3 Many lncRNAs are taken part in the occurrence of EC. 11,30 LINC01410 is highly expressed both in EC tissues and cells and the up-regulation of LINC01410 is closely related to tumor stage. 11 LINC01220 expression is dramatically up-regulated in EC tissues and its high expression is strongly associated with tumor stage.…”

Section: Discussionmentioning

confidence: 99%

“…30 The proliferation and invasion of EC cells are restrained by LINC01410 knockdown. 11 Suppression of LINC01016 inhibits the proliferation, migration and invasion of EC cells. 10 In this study, we discovered that LINC01106 inhibition suppressed the proliferation, migration and invasion of EC cells.…”

Section: Dovepressmentioning

confidence: 99%

“…Long non-coding RNAs (LncRNAs) are participated in modulating the tumorigenesis and progression of many human cancers, [6][7][8] including EC. [9][10][11] For instance, overexpression of LINC-ROR is reported to promote the growth of EC. 9 Up-regulation of LINC01016 accelerates the malignant biological behaviors of EC cells, such as increasing the proliferation and invasion abilities of EC cells.…”

Section: Introductionmentioning

confidence: 99%

“…10 LINC01410 overexpression can also facilitate the proliferation and invasion of EC cells. 11 Notably, the emerging evidences have displayed that LINC01106 is related to the occurrence and progression of several cancers, such as nasopharyngeal carcinoma, 12 lung adenocarcinoma 13 and colorectal cancer. 14 However, whether LINC01106 involves in regulating EC progression has not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

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<p>Silencing of Long Non-Coding RNA LINC01106 Suppresses the Proliferation, Migration and Invasion of Endometrial Cancer Cells Through Regulating the miR-449a/MET Axis</p>

Gao¹,

Yu²,

Zhang³

et al. 2020

OTT

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Endometrial cancer (EC) is an aggressive tumor in females and the development of EC is considered to regulate by some long non-coding RNAs (lncRNAs). Therefore, this study aimed to investigate the regulatory mechanism of lncRNA LINC01106 on EC. Methods: The expression of lncRNA LINC01106, miR-449a and MET in EC tissues and cells was detected by qRT-PCR. Through MTT, wound healing and transwell invasion assays, the proliferation, migration and invasion of EC cells were detected, respectively. The xenograft tumor model was constructed in nude mice to confirm the inhibiting effect of LINC01106 knockdown on EC in vivo. The interactions between miR-449a and LINC01106/ MET were predicted by Starbase/Targetscan software and verified by the dual-luciferase reporter assay or RNA immunoprecipitation assay. Western blot assay was performed to determine the protein level of MET. Results: LncRNA LINC01106 expression was highly up-regulated in EC tissues and cells. The proliferation, migration and invasion of EC cells in vitro were inhibited by the transfection of sh-LINC01106. The growth of tumor xenograft was suppressed by injection of sh-LINC01106. MiR-449a was a target of LINC01106and was negatively modulated by LINC01106. MiR-449a overexpression suppressed the proliferation, migration and invasion of EC cells. In addition, MET was identified as a target gene of miR-449a. Both the high expression of miR-449a and low expression of MET reversed the inhibiting effects of LINC01106 knockdown on Ishikawa cells. Conclusion: Silencing of LINC01106 inhibits the occurrence and development of EC via regulating the miR-449a/MET axis. This study provides a possible therapeutic strategy for EC.

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Section: Discussionmentioning

confidence: 99%

Section: Dovepressmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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<p>Silencing of Long Non-Coding RNA LINC01106 Suppresses the Proliferation, Migration and Invasion of Endometrial Cancer Cells Through Regulating the miR-449a/MET Axis</p>

Gao¹,

Yu²,

Zhang³

et al. 2020

OTT

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“… 27 Besides, Lu et al pointed out that LINC01410 was overexpressed in endometrial cancer tissues, and accelerated endometrial cancer cell progression through miR-23c/CHD7 axis. 28 Moreover, Jiang et al uncovered that LINC01410 knockdown inhibited cholangiocarcinoma cell proliferation and metastasis via sponging miR-124-3p to decrease SMAD5 expression. 29 In our research, it was found that LINC01410 abundance was elevated in NB tissues and cells.…”

Section: Discussionmentioning

confidence: 99%

Long Noncoding RNA LINC01410 Suppresses Tumorigenesis and Enhances Radiosensitivity in Neuroblastoma Cells Through Regulating miR-545-3p/HK2 Axis

Mou¹,

Wang²,

Zhang³

et al. 2021

OTT

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Background: Abnormal expression of long noncoding RNAs (lncRNAs) was often involved in tumorigenesis and radiosensitivity of various cancers. The aim of this study was to explore the biological function and regulatory mechanism of lncRNA long intergenic non-protein coding RNA 1410 (LINC01410) in tumorigenesis and radiosensitivity of neuroblastoma (NB). Methods: The expression of LINC01410, microRNA-329-3p (miR-545-3p) and hexokinase 2 (HK2) was detected by quantitative real-time polymerase chain reaction (qRT-PCR). Methylthiazolyldiphenyl tetrazolium bromide (MTT) assay, colony formation assay and transwell assay were utilized to detect cell viability, colony formation and cell invasion abilities. Glucose consumption or lactate production was measured by glucose assay kit or lactate assay kit, respectively. The interaction between miR-545-3p and LINC01410 or HK2 was predicted by starBase v2.0 and verified by dual-luciferase reporter, RNA Immunoprecipitation (RIP) and RNA pull-down assays. Western blot was used to measure the protein expression of HK2. The mice xenograft model was established to investigate the role of LINC01410 in vivo. Results: LINC01410 and HK2 were highly expressed while miR-545-3p was lowly expressed in NB tissues and cells. LINC01410 knockdown inhibited tumorigenesis by repressing cell proliferation and invasion, and increased the radiosensitivity via inhibiting colony formation rates and glycolysis. LINC01410 knockdown also suppressed tumor growth in vivo. Moreover, miR-545-3p could bind to LINC01410 and its downregulation reversed the effects of LINC01410 knockdown on tumorigenesis and radiosensitivity. Additionally, HK2 was a direct target of miR-545-3p and its overexpression attenuated the effects of miR-545-3p restoration on suppression of tumorigenesis and promotion of radiosensitivity. Besides, LINC01410 functioned as a molecular sponge of miR-545-3p to regulate HK2 expression. Conclusion: LINC01410 interference inhibited tumorigenesis and increased radiosensitivity via regulating miR-545-3p/HK2 axis, providing a novel therapeutic strategy for NB.

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Long Non-coding RNAs in Cancer

Nadhan,

Isidoro,

Song

et al. 2023

Handbook of Oncobiology: From Basic to Clinical Sciences

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LINC01410/miR-23c/CHD7 functions as a ceRNA network to affect the prognosis of patients with endometrial cancer and strengthen the malignant properties of endometrial cancer cells

Cited by 21 publications

References 29 publications

<p>Silencing of Long Non-Coding RNA LINC01106 Suppresses the Proliferation, Migration and Invasion of Endometrial Cancer Cells Through Regulating the miR-449a/MET Axis</p>

<p>Silencing of Long Non-Coding RNA LINC01106 Suppresses the Proliferation, Migration and Invasion of Endometrial Cancer Cells Through Regulating the miR-449a/MET Axis</p>

Long Noncoding RNA LINC01410 Suppresses Tumorigenesis and Enhances Radiosensitivity in Neuroblastoma Cells Through Regulating miR-545-3p/HK2 Axis

Long Non-coding RNAs in Cancer

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