LINC01354 enhances the proliferation and invasion of lung cancer cells by regulating miR-340-5p/ATF1 signaling pathway

Yang, Gaojie; Yang, Chongyi; She, Yahui; Shen, Zuojun; Gao, Peng

doi:10.1080/21691401.2019.1667816

Cited by 19 publications

(18 citation statements)

References 23 publications

(24 reference statements)

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“…Cell luciferase activity was measured by a dual luciferase detection kit (GeneCopoeia, Rockville, USA). Relative luciferase activity = firefly/Renilla luciferase activity [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer

Zhang

Zhao

et al. 2022

Nanoscale Res Lett

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Objective LINC01354 has been defined as a tumor driver in several cancers. Nevertheless, whether LINC01354 involves in endometrial cancer (EC) has been little navigated. Thus, the mechanism of LINC01354 was explored in the disease. Methods Measurements of LINC01354, microRNA (miR)-216b and kirsten rat sarcoma viral oncogene (KRAS) levels in EC tissues and cells were performed. LINC01354 low expression and miR-216b overexpression vectors were introduced into EC cells (lshikawa), thereby their effects on cell viability, apoptosis, migration and invasion were manifested. Rescue experiments were also carried out by down-regulating LINC01354 and miR-216b spontaneously. Tumorigenesis in vivo was also assessed. The relationships of LINC01354/miR-216b/KRAS were analyzed. Results Increased LINC01354 and KRAS and reduced miR-216b levels were measured in EC. Silencing LINC01354 or overexpressing miR-216b retarded EC cellular development. LINC01354 counteracted with miR-216b to target KRAS. Suppression of miR-216b antagonized silenced LINC01354-induced impacts on EC cell development. LINC01354/miR-216b/KRAS axis enhanced tumorigenesis in mice with EC. Conclusion It is testified that silencing LINC01354 inhibits KRAS by up-regulating miR-216b, thereby discouraging cell malignant phenotype in EC.

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“…Cell luciferase activity was measured by a dual luciferase detection kit (GeneCopoeia, Rockville, USA). Relative luciferase activity = firefly/Renilla luciferase activity [ 11 ].…”

Section: Methodsmentioning

confidence: 99%

RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer

Zhang

Zhao

et al. 2022

Nanoscale Res Lett

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“…Among the prognostic signature lncRNAs, the oncogenic function of LINC01354 has been studied in a variety of cancers—in particular, in colorectal carcinoma, gastric carcinoma, lung carcinoma, and neck squamous cell carcinoma—in which LINC01354 accelerates the proliferation response, migration, and infiltration of cancer cells. 72 , 73 , 74 , 75 , 76 This study found suppression of LINC01354 expression in Myc high tumor tissues compared with Myc low tumor tissues. LINC02499 is highly expressed in HCC and inhibits cell-proliferation capacity, migration, and immune cell infiltration in HCC 77 and was first analyzed in the associated Myc ceRNA network.…”

Section: Discussionmentioning

confidence: 53%

Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma

Zhang

Shi

Liu

et al. 2021

Molecular Therapy - Nucleic Acids

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Hepatocellular carcinoma (HCC) remains an extremely lethal disease worldwide. High-throughput methods have revealed global transcriptome dysregulation; however, a comprehensive investigation of the complexity and behavioral characteristics of the competing endogenous RNA (ceRNA) network in HCC is lacking. In this study, we extracted the transcriptome (RNA) sequencing data of 371 HCC patients from The Cancer Genome Atlas platform. With the comparison of the high Myc expression (Myc high ) tumor and low Myc expression (Myc low ) tumor groups in HCC, we identified 1,125 differentially expressed (DE) mRNAs, 589 long non-coding RNAs (lncRNAs), and 93 microRNAs (miRNAs). DE RNAs predicted the interactions necessary to construct an associated Myc ceRNA network, including 19 DE lncRNAs, 5 miRNAs, and 72 mRNAs. We identified a significant signature (long intergenic non-protein-coding [LINC] RNA 2691 [LINC02691] and LINC02499) that effectively predicted overall survival and had protective effects. The target genes of microRNA (miR)-212-3p predicted to intersect with DE mRNAs included SEC14-like protein 2 (SEC14L2) and solute carrier family 6 member 1 (SLC6A1), which were strongly correlated with survival and prognosis. With the use of the lncRNA-miRNA-mRNA axis, we constructed a ceRNA network containing four lncRNAs (LINC02691, LINC02499, LINC01354, and NAV2 antisense RNA 4), one miRNA (miR-212-3p), and two mRNAs (SEC14L2 and SLC6A1). Overall, we successfully constructed a mutually regulated ceRNA network and identified potential precision-targeted therapies and prognostic biomarkers.

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“…Our results confirm that PCNAP1 directly targets miR-340-5p and results in an increased expression of ATF7, consistent with a previous study that miR-340-5p inhibits HCC cell proliferation by directly targeting ATF7 [ 16 ]. MiR-340-5p is well known to act as a tumor suppressor in a variety of cancers [ 16 , 21 – 24 ]. One of the targets of miR-340-5p in HCC is ATF7, which is involved in cancer cell proliferation [ 16 , 25 ].…”

Section: Discussionmentioning

confidence: 99%

LncRNA PCNAP1 Promotes Hepatoma Cell Proliferation through Targeting miR-340-5p and is Associated with Patient Survival

Bai

et al. 2021

Journal of Oncology

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Hepatocellular carcinoma (HCC) is one of the most common malignancies and causes poor outcome. Dysregulation of long noncoding RNA (lncRNA) is involved in HCC. Upregulation of the lncRNA PCNAP1 has been reported to promote HBV-infectious HCC growth, but its clinical significance and underlying mechanisms in HCC development remain unclear. Here, we report that PCNAP1 expression is increased in both HBV-infectious and noninfectious HCC tissues compared with matched normal tissues, and its upregulation correlates with poor survival rates of HCC patients. Furthermore, we found that PCNAP1 promotes HCC cell proliferation through acting as a competitive endogenous RNA (ceRNA) to sponge miR-340-5p, which has been reported to directly inhibit ATF7 expression in HCC cells. Moreover, the PCNAP1/miR-340-5p/ATF7 signaling associates with the poor survival rates of HCC patients. Collectively, our findings suggest that the PCNAP1/miR-340-5p/ATF7 signaling may be a potential biomarker for the prognosis of HCC patients and a potential therapeutic target for HCC.

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LINC01354 enhances the proliferation and invasion of lung cancer cells by regulating miR-340-5p/ATF1 signaling pathway

Cited by 19 publications

References 23 publications

RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer

RETRACTED ARTICLE: LINC01354/microRNA-216b/KRAS Axis Promotes the Occurrence and Metastasis of Endometrial Cancer

Construction of a Myc-associated ceRNA network reveals a prognostic signature in hepatocellular carcinoma

LncRNA PCNAP1 Promotes Hepatoma Cell Proliferation through Targeting miR-340-5p and is Associated with Patient Survival

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