LINC01296 promotes proliferation of cutaneous malignant melanoma by regulating miR-324-3p/MAPK1 axis

Wang, Kang; Luo, Qin; Zhang, Yingfeng; Xie, Xin; Cheng, Wen‐Hao; Yao, Qiunan; Chen, Yingying; Ren, Hong; Li, Jiuping; Pan, Zuanqin

doi:10.18632/aging.204413

Cited by 2 publications

(1 citation statement)

References 27 publications

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“…In fact, no primary focus is found in about 2-5% of patients with MM, which is called "MM without a primary focus" (12)(13)(14). The prognosis of MM without a primary focus is better than that of MM with a primary focus, which may be due to immune-induced complete regression of the primary tumor and better prevention or control of distant metastatic diseases (15). In addition, in some patients with MM without a primary focus, MM originates from nevus cells within lymph nodes and is not metastatic.…”

Section: Discussionmentioning

confidence: 99%

Misdiagnosis and treatment of a case of malignant melanoma found in an axillary mass: case report and review

Chang-hai

Liu

et al. 2023

Preprint

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Background Malignant melanoma (MM) is a highly dangerous, potentially fatal tumor originating from melanocytes in the neural crest. It most often occurs in the skin, and regional lymph nodes (inguinal, axillary, cervical, and others) can metastasize at an early stage. Malignant tumors not involving the hematopoietic system initially appear as axillary masses, constituting a unique clinical manifestation. Moreover, MM in an axillary mass is difficult to diagnose preoperatively and is easily misidentified. Case presentation: Here, we report on a 62-year-old woman with MM occurring within an axillary mass; it was initially misdiagnosed as synovial sarcoma and fibrosarcoma. Under general anesthesia, the patient underwent radical surgery of a right axillary lymph node; she then received six cycles of chemotherapy. About 14 months later, the lesion recurred and metastasized to the chest wall and breast skin. After biopsy of the skin nodules on the chest wall as well as examination by immunohistochemistry(IHC) and gene detection, the lesion was confirmed to be a MM. Finally, after two cycles of targeted drug treatment, the lesions in the armpit, chest wall, and breast skin disappeared. Conclusion MM is an often lethal, highly malignant, easily misdiagnosed form of cancer that requires careful study, following its clinical course, and scrutinizing the findings from imaging, pathology, immunohistochemistry, and gene detection.

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Section: Discussionmentioning

confidence: 99%

Misdiagnosis and treatment of a case of malignant melanoma found in an axillary mass: case report and review

Chang-hai

Liu

et al. 2023

Preprint

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Investigating the potential mechanisms of Litsea cubeba essential oil for anti-melanoma through experimental validation, network pharmacology, and molecular docking analysis

Yang,

Liu,

Han

et al. 2024

Oncologie

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Objectives Melanoma remains a challenge due to the lack of effective and low-toxicity treatments. Litsea cubeba essential oil (LEO), known for its tyrosinase inhibitory activity, has shown promise as an anti-melanoma compound, although robust scientific evidence is lacking. Methods We conducted GC-MS analysis to identify the major components of LEO and screened for effective components were further evaluated on A375 and HaCaT cells using the CCK-8 assay. Network pharmacology was employed to predict potential targets using PharmMapper and SwissTarget Prediction databases, with melanoma-related targets sourced from the GeneCards database. Protein–protein interaction (PPI) network was created using STRING and Cytoscape. Gene Ontology (GO) and Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway enrichment analyses were performed through the DAVI database. Additionally, we constructed a natural product-main components-core targets-pathways-disease (NMCPD) network in Cytoscape and conducted molecular docking using PyMOL and Autodock Vina. Results GC-MS analysis revealed neral (cis-citral) and geranial (trans-citral) as the primary active components of LEO. Cell assays demonstrated that a citral mixture, in combination with LEO, effectively inhibited A375 cell growth with IC50 values of 35.94 ± 1.23 μM and 12.00 ± 0.96 μg/mL, while exhibiting minimal toxicity to HaCaT cells with IC50 values of 67.72 ± 2.96 μM and 22.32 ± 2.53 μg/mL. Screening identified10 hub targets among 190 common targets between drug and disease-related targets. KEGG pathway enrichment analysis suggested therapeutic effects of citral on melanoma by modulating signaling pathways. Molecular docking revealed strong binding affinity of neral and geranial with RXRA and ESR1, suggesting that citral, the principal LEO component, regulates multiple pathways for potential melanoma therapy. Conclusions These findings support the potential utility of LEO as a treatment for melanoma and highlight the importance of exploring tyrosinase inhibitors for the development of novel anti-melanoma drugs.

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LINC01296 promotes proliferation of cutaneous malignant melanoma by regulating miR-324-3p/MAPK1 axis

Cited by 2 publications

References 27 publications

Misdiagnosis and treatment of a case of malignant melanoma found in an axillary mass: case report and review

Misdiagnosis and treatment of a case of malignant melanoma found in an axillary mass: case report and review

Investigating the potential mechanisms of Litsea cubeba essential oil for anti-melanoma through experimental validation, network pharmacology, and molecular docking analysis

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