Linc01116 Silencing Inhibits the Proliferation and Invasion,
Promotes Apoptosis of Chordoma Cells via Regulating the
Expression of Mir-9-5p/PKG1
Junqi Liu,
Yan Qi,
Siyuan Hou
et al.
Abstract:Background:
Long intergenic non-protein coding RNA 1116 (LINC01116)
plays a carcinogenic role in a variety of cancers. The study aims to investigate the roles
of LINC01116 and hsa-miR-9-5p (miR-9-5p) and fathom their interaction in chordoma.
Method:
The predicted binding sites between miR-9-5p with LINC01116 and
phosphoglycerate kinase 1 (PGK1) by starBase were confirmed through dual-luciferase
reporter assay. The behaviors of chordoma cells undergoing transfection with
siLINC01116 or miR-9-5p inhibitor were… Show more
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