LINC01116 promotes tumor proliferation and neutrophil recruitment via DDX5-mediated regulation of IL-1β in glioma cell

Wang, Teng; Cao, Lihua; Dong, Xin; Wu, Fei; De, Wei; Huang, Lin; Wan, Qi

doi:10.1038/s41419-020-2506-0

Cited by 40 publications

(39 citation statements)

References 56 publications

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“…LncRNA genes play important roles in many biological processes. For example, LINC01116 promotes tumor proliferation, migration, and invasion in glioma cell (27,28). However, the role of AC093278.2, AC004067.1, and AC017104.1 in GBM has not been reported, and it is important that it is elucidated in future studies.…”

Section: G Hmentioning

confidence: 99%

Identification of an IFN-β-associated gene signature for the prediction of overall survival among glioblastoma patients

Cheng¹,

Yuan²,

Li³

et al. 2021

Ann Transl Med

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Background: Brain glioblastoma multiforme (GBM) is the most common primary malignant intracranial tumor. The prognosis of this disease is extremely poor. While the introduction of β-interferon (IFN-β) regimen in the treatment of gliomas has significantly improved the outcome of patients; The mechanism by which IFN-β induces increased TMZ sensitivity has not been described. Therefore, the main objective of the study was to elucidate the molecular mechanisms responsible for the beneficial effect of IFNβ in GBM.Methods: Messenger RNA expression profiles and clinicopathological data were downloaded from The Cancer Genome Atlas (TCGA) GBM and GSE83300 dataset from the Gene Expression Omnibus.Univariate Cox regression analysis and lasso Cox regression model established a novel 4-gene IFN-β signature (peroxiredoxin 1, Sec61 subunit beta, X-ray repair cross-complementing 5, and Bcl-2-like protein 2) for GBM prognosis prediction. Further, GBM samples (n=50) and normal brain tissues (n=50) were then used for real-time polymerase chain reaction experiments. Gene set enrichment analysis (GSEA) was performed to further understand the underlying molecular mechanisms. Pearson correlation was applied to calculate the correlation between the long non-coding RNAs (lncRNAs) and IFN-β-associated genes.An lncRNA with a correlation coefficient |R 2 |>0.3 and P<0.05 was considered to be an IFN-β-associated lncRNA.Results: Patients in the high-risk group had significantly poorer survival than patients in the low-risk group. The signature was found to be an independent prognostic factor for GBM survival. Furthermore, GSEA revealed several significantly enriched pathways, which might help explain the underlying mechanisms. Our study identified a novel robust 4-gene IFN-β signature for GBM prognosis prediction.The signature might contain potential biomarkers for metabolic therapy and treatment response prediction for GBM patients.Conclusions: In the present study, we established a novel IFN-β-associated gene signature to predict the overall survival of GBM patients, which may help in clinical decision making for individual treatment.

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Section: G Hmentioning

confidence: 99%

Identification of an IFN-β-associated gene signature for the prediction of overall survival among glioblastoma patients

Cheng¹,

Yuan²,

Li³

et al. 2021

Ann Transl Med

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“…Recently, it has been reported that long intergenic nonprotein coding RNA 01116 (LINC01116) promotes nasopharyngeal carcinoma development 9 and accelerates tumor proliferation in glioma. 10 Silencing LINC01116 may inhibit the progression of oral squamous cell carcinoma via microRNA (miR)‐136‐mediated fibronectin 1 (FN1) inhibition. 11 Additionally, LINC01116 has been found to exacerbate lung squamous cell carcinoma progression via targeting the miR‐744‐5p/ sodium voltage‐gated channel beta subunit 1 (SCN1B) axis.…”

Section: Introductionmentioning

confidence: 99%

Silencing LINC01116 suppresses the development of lung adenocarcinoma via the AKT signaling pathway

Shang

et al. 2021

Thoracic Cancer

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Background: A growing body of evidence has proven that long noncoding ribonucleic acids (lncRNAs) are important epigenetic regulators that play crucial parts in the pathogenesis of human cancers. Previous studies have shown that long intergenic nonprotein coding RNA 01116 (LINC01116) is a carcinogen in several carcinomas; however, its function in lung adenocarcinoma (LUAD) has not been clarified. Here, we aimed to investigate the role of LINC01116 in LUAD. Methods: The relative expression levels of LINC01116 in LUAD cell lines and tissues were detected by quantitative reverse transcription polymerase chain reaction. A Kaplan-Meier survival analysis was performed using patient information from the Gene Expression Profiling Interactive Analysis (GEPIA) database. LUAD proliferation, invasion, migration, and apoptosis were measured by performing cell counting kit-8, colony formation, transwell, wound healing, and flow cytometric assays. A xenograft animal experiment was performed to investigate the effect of LINC01116 in vivo. Protein kinase B (AKT) signaling pathway-related protein expressions were tested by Western blot assay. Results: LINC01116 expression was upregulated in LUAD cells and tissues. The lossof-function experiments on LUAD cells revealed that silencing LINC01116 expression could decrease cell viability both in vitro and in vivo. Furthermore, silencing LINC01116 inhibited LUAD cell invasion and migration and induced cell apoptosis. Mechanically, silencing LINC01116 significantly decreased p-AKT protein levels, and an AKT pathway stimulator could rescue the suppressive effects of small interfering LINC011116-specific RNAs on LUAD development. Conclusions: Our study demonstrated that silencing LINC01116 suppresses the development of LUAD via the AKT signaling pathway.

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“…For these reasons, they reaffirm the need for a multi-targeted approach through a modulation of the TAM. Furthermore, tumor-associated neutrophils (TAN) are found to be involved in necrosis onset in glioblastoma patients [ 105 , 106 ]. In this context, the mechanism of necrosis could be a neutrophil-mediated ferroptosis.…”

Section: Resultsmentioning

confidence: 99%

Diagnosis and Management of Glioblastoma: A Comprehensive Perspective

Gilard

Tebani

Dabaj

et al. 2021

JPM

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Glioblastoma is the most common malignant brain tumor in adults. The current management relies on surgical resection and adjuvant radiotherapy and chemotherapy. Despite advances in our understanding of glioblastoma onset, we are still faced with an increased incidence, an altered quality of life and a poor prognosis, its relapse and a median overall survival of 15 months. For the past few years, the understanding of glioblastoma physiopathology has experienced an exponential acceleration and yielded significant insights and new treatments perspectives. In this review, through an original R-based literature analysis, we summarize the clinical presentation, current standards of care and outcomes in patients diagnosed with glioblastoma. We also present the recent advances and perspectives regarding pathophysiological bases as well as new therapeutic approaches such as cancer vaccination and personalized treatments.

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LINC01116 promotes tumor proliferation and neutrophil recruitment via DDX5-mediated regulation of IL-1β in glioma cell

Cited by 40 publications

References 56 publications

Identification of an IFN-β-associated gene signature for the prediction of overall survival among glioblastoma patients

Identification of an IFN-β-associated gene signature for the prediction of overall survival among glioblastoma patients

Silencing LINC01116 suppresses the development of lung adenocarcinoma via the AKT signaling pathway

Diagnosis and Management of Glioblastoma: A Comprehensive Perspective

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