LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors
            <i>in vitro</i>
            and tumor growth and metastasis
            <i>in vivo</i>
            through the PI3K/Akt signaling

Zhang, Q; Tang, Xinqiao; Zhou, Yi; Chen, Xiaoming; Peng, Ke; Jiang, Rui; Liu, Zhong; Song, Xiaoxia; Xia, Hong

doi:10.1080/15384047.2023.2198904

Cited by 5 publications

(1 citation statement)

References 49 publications

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“…The PI3K-Akt pathway is widely activated in various tumors and is closely associated with tumor development (56)(57)(58)(59). Gram-positive anaerobic bacteria, such as Peptostreptococcus anaerobius (P. anaerobius), present in the oral cavity and intestines (60), could bind to integrin a2b1 on the surface of CRC cells through its surface protein called putative cell wall binding repeat 2 (PCWBR2).…”

Section: Activating the Cascades Of Cancer Signalingmentioning

confidence: 99%

Gut microbiota: key facilitator in metastasis of colorectal cancer

Yu,

Wang,

Xiong

et al. 2023

Front. Oncol.

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Colorectal cancer (CRC) ranks third in terms of incidence among all kinds of cancer. The main cause of death is metastasis. Recent studies have shown that the gut microbiota could facilitate cancer metastasis by promoting cancer cells proliferation, invasion, dissemination, and survival. Multiple mechanisms have been implicated, such as RNA-mediated targeting effects, activation of tumor signaling cascades, secretion of microbiota-derived functional substances, regulation of mRNA methylation, facilitated immune evasion, increased intravasation of cancer cells, and remodeling of tumor microenvironment (TME). The understanding of CRC metastasis was further deepened by the mechanisms mentioned above. In this review, the mechanisms by which the gut microbiota participates in the process of CRC metastasis were reviewed as followed based on recent studies.

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Section: Activating the Cascades Of Cancer Signalingmentioning

confidence: 99%

Gut microbiota: key facilitator in metastasis of colorectal cancer

Yu,

Wang,

Xiong

et al. 2023

Front. Oncol.

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FRS2 regulated by miR-429 and miR-206 promotes angiogenesis in osteosarcoma

Zhu,

Liu,

Cao

et al. 2024

Gene

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Prognosis and chemotherapy drug sensitivity in liver hepatocellular carcinoma through a disulfidptosis-related lncRNA signature

Chen,

Wang,

et al. 2024

Sci Rep

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Disulfidptosis, a new type of regulated cell death associated with the actin cytoskeleton, provides a new therapeutic tool for cancers. The direct relationship between disulfidptosis-related lncRNAs(DRLs) in liver hepatocellular carcinoma(HCC) remains unclear. We acquired transcriptomic data, corresponding clinical data, and tumor mutation data of HCC from the TCGA database. First of all, DRLs were determined through correlation analysis. Then, a prognostic model containing six DRLs was created by adopting univariate Cox regression, LASSO algorithm and multivariate Cox regression analysis. Based on the model, 424 HCC patients were divided into high- and low-risk groups. Next, we structured ROC curves and PCA through combining the model and clinical data. Enrichment analysis and immune infiltration analysis were adopted to further explore the relationship between the model and prognosis. In addition, we explored the relationship between the model and tumor mutation burden (TMB). There were significant differences between high- and low- risk groups, and patients in the high-risk group showed poor prognosis. Enrichment analysis suggested that metabolic progress was obviously different between the two groups. According to the analysis of immune infiltration, there were several differences in immune cells, function, and checkpoints. Patients with high-risk and high TMB demonstrated the least favorable prognosis. The two risk groups both manifested visiblly in chemotherapy drug sensitivity. To sum up, we set up a DRL-based signature and that may provide a predictable value for the prognosis and use of chemotherapy drugs for HCC patients.

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LINC01060 knockdown inhibits osteosarcoma cell malignant behaviors in vitro and tumor growth and metastasis in vivo through the PI3K/Akt signaling

Cited by 5 publications

References 49 publications

Gut microbiota: key facilitator in metastasis of colorectal cancer

Gut microbiota: key facilitator in metastasis of colorectal cancer

FRS2 regulated by miR-429 and miR-206 promotes angiogenesis in osteosarcoma

Prognosis and chemotherapy drug sensitivity in liver hepatocellular carcinoma through a disulfidptosis-related lncRNA signature

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