LINC00968 promotes osteogenic differentiation in vitro and bone formation in vivo via regulation of miR-3658/RUNX2

Liao, Chunhui; Zhou, Yutao; Li, Mingfei; Xia, Yixin; Peng, Wei

doi:10.1016/j.diff.2020.09.005

Cited by 18 publications

(8 citation statements)

References 29 publications

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“…Meanwhile, different lncRNAs may affect the expression of the same target oppositely, for example, RUNX2. To illustrate, lncRNA MEG3 inhibited human DPSCs osteogenic differentiation and promoted RUNX2 degradation via miR-543/SMURF1/RUNX2 regulatory network (Zhao et al, 2020c), whereas lncRNA LINC00968 promoted osteogenic differentiation and bone formation in vitro and in vivo and upregulated RUNX2 expression through competitive binding of miR-3658 (Liao et al, 2020). Besides, some chemical compounds, such as berberine (BBR), were recently identified to contribute to the osteogenic differentiation of DPSCs (Xin et al, 2020).…”

Section: Osteogenesismentioning

confidence: 99%

Dental-Derived Mesenchymal Stem Cells: State of the Art

Ouchi

Cao

et al. 2021

Front. Cell Dev. Biol.

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Mesenchymal stem cells (MSCs) could be identified in mammalian teeth. Currently, dental-derived MSCs (DMSCs) has become a collective term for all the MSCs isolated from dental pulp, periodontal ligament, dental follicle, apical papilla, and even gingiva. These DMSCs possess similar multipotent potential as bone marrow-derived MSCs, including differentiation into cells that have the characteristics of odontoblasts, cementoblasts, osteoblasts, chondrocytes, myocytes, epithelial cells, neural cells, hepatocytes, and adipocytes. Besides, DMSCs also have powerful immunomodulatory functions, which enable them to orchestrate the surrounding immune microenvironment. These properties enable DMSCs to have a promising approach in injury repair, tissue regeneration, and treatment of various diseases. This review outlines the most recent advances in DMSCs’ functions and applications and enlightens how these advances are paving the path for DMSC-based therapies.

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Section: Osteogenesismentioning

confidence: 99%

Dental-Derived Mesenchymal Stem Cells: State of the Art

Ouchi

Cao

et al. 2021

Front. Cell Dev. Biol.

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“…LINC00968 promotes osteogenic differentiation of DPSCs via regulation of miR-3658/RUNX2 ( Liao et al, 2020 ). LncRNA FER1L4 promotes osteogenic differentiation of human PDLSCs via targeting miR-874-3p ( Huang et al, 2020 ).…”

Section: Regulatory Mechanisms Of Ncrnas In the Differentiation Of Dmscsmentioning

confidence: 99%

Progress in the Study of Non-Coding RNAs in Multidifferentiation Potential of Dental-Derived Mesenchymal Stem Cells

Zeng

2022

Front. Genet.

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For decades, the desire for tissue regeneration has never been quenched. Dental-derived mesenchymal stem cells (DMSCs), with the potential of self-renewal and multi-directional differentiation, have attracted much attention in this topic. Growing evidence suggests that non-coding RNAs (ncRNAs) can activate various regulatory processes. Even with a slight decrease or increase in expression, ncRNAs can weaken or even subvert cellular fate. Therefore, a systematic interpretation of ncRNAs that guide the differentiation of DMSCs into cells of other tissue types is urgently needed. In this review, we introduce the roles of ncRNAs in the differentiation of DMSCs, such as osteogenic differentiation, odontogenic differentiation, neurogenic differentiation, angiogenic differentiation and myogenic differentiation. Additionally, we illustrate the regulatory mechanisms of ncRNAs in the differentiation of DMSCs, such as epigenetic regulation, transcriptional regulation, mRNA modulation, miRNA sponges and signalling. Finally, we summarize the types and mechanisms of ncRNAs in the differentiation of DMSCs, such as let-7 family, miR-17∼92 family, miR-21, lncRNA H19, lncRNA ANCR, lncRNA MEG3, circRNA CDR1as and CircRNA SIPA1L1. If revealing the intricate relationship between ncRNAs and pluripotency of DMSCs 1 day, the application of DMSCs in regenerative medicine and tissue engineering will be improved. Our work could be an important stepping stone towards this future.

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“…In this circumstance, lncRNAs function as competitive endogenous RNAs (ceRNAs), which correspond to miRNA sponges or antagomirs, to affect the expression levels and activities of miRNAs, thereby repressing miRNA targets and causing an additional level of posttranscriptional regulation [ 177 ]. Previous studies have shown that lncRNAs regulate gene expression and function by competing with miRNAs for binding to target mRNAs [ 178 ]. Two thousand and one hundred sixty-two lncRNAs were differentially expressed between PDLSCs and GMSCs.…”

Section: Epigenetic Modifications In Dental-derived Mscsmentioning

confidence: 99%

Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells

Chen

Zheng

Rao

et al. 2021

Stem Cells International

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As a novel research hotspot in tissue regeneration, dental-derived mesenchymal stromal cells (MSCs) are famous for their accessibility, multipotent differentiation ability, and high proliferation. However, cellular heterogeneity is a major obstacle to the clinical application of dental-derived MSCs. Here, we reviewed the heterogeneity of dental-derived MSCs firstly and then discussed the key markers and epigenetic modifications related to the proliferation, differentiation, immunomodulation, and aging of dental-derived MSCs. These messages help to control the composition and function of dental-derived MSCs and thus accelerate the translation of cell therapy into clinical practice.

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LINC00968 promotes osteogenic differentiation in vitro and bone formation in vivo via regulation of miR-3658/RUNX2

Cited by 18 publications

References 29 publications

Dental-Derived Mesenchymal Stem Cells: State of the Art

Dental-Derived Mesenchymal Stem Cells: State of the Art

Progress in the Study of Non-Coding RNAs in Multidifferentiation Potential of Dental-Derived Mesenchymal Stem Cells

Key Markers and Epigenetic Modifications of Dental-Derived Mesenchymal Stromal Cells

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