LINC00847 drives pancreatic cancer progression by targeting the miR-455-3p/HDAC4 axis
Shunxin Hao,
Zhi Yao,
Yifeng Liu
Abstract:IntroductionPancreatic cancer (PC) is a common malignant tumor of the digestive system, posing a serious threat to the life of patients. This study aims to investigate the role of LINC00847 and the LINC00847/miR-455-3p/HDAC4 mechanism in PC progression.Material and methodsThe RNA levels of LINC00847, miR-455-3p and HDAC4 were determined by RT-qPCR. HDAC4 protein level was assessed by western blotting. Colony formation and CCK-8 assays were employed to test the proliferation of PC cells. Transwell and scratch a… Show more
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