Linc00668 Promotes Invasion and Stem Cell-Like Properties of Breast Cancer Cells by Interaction With SND1

Qian, Wangsheng; Zhu, Yong; Wu, Mingming; Guo, Qianying; Wu, Zhengsheng; Lobie, Peter E.; Zhu, Tao

doi:10.3389/fonc.2020.00088

Cited by 15 publications

(9 citation statements)

References 54 publications

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“…Numerous studies have reported LncRNAs’ functions in tumor progression depended on their interaction with RNA-binding proteins (RBPs) ( 7 , 22 ). We also seek to identify the RBPs could physically interact with LINC00467 and mediate its oncogenic role in breast cancer progression.…”

Section: Resultsmentioning

confidence: 99%

“…Long noncoding RNAs (lncRNAs), a class of RNA molecules longer than 200 nucleotides, with less protein-coding capacity, have been reported to play crucial roles in multiple cellular processes, tumor progression included (4)(5)(6). In general, LncRNAs function via interacting with proteins, chromatin DNA or other types of RNAs to mediate their stability or activity in different aspects of tumor biology (7)(8)(9)(10). LINC00467 (ID in NCBI database: 84791), a LncRNA has attracted much attention recently, was reported to be dysregulated in spermatogenesis and male infertility (11,12).…”

Section: Introductionmentioning

confidence: 99%

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Long Non-Coding RNA LINC00467 Correlates to Poor Prognosis and Aggressiveness of Breast Cancer

et al. 2021

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Breast cancer remains the leading cause of female cancer-related mortalities worldwide. Long non-coding RNAs (LncRNAs) have been increasingly reported to play pivotal roles in tumorigenesis and cancer progression. Herein, we focused on LINC00467, which has never been studied in breast cancer. Silence of LINC00467 suppressed proliferation, migration, invasion and epithelial-to-mesenchymal transition (EMT) of breast cancer cells in vitro, whereas forced expression of LINC00467 exhibited the opposite effects. Furthermore, we demonstrated overexpression of LINC00467 promoted tumor growth, while knockdown of LINC00467 inhibited pulmonary metastasis in vivo. Mechanistically, LINC00467 down-regulated miR-138-5p by acting as a miRNA “sponge”. Besides, LINC00467 also up-regulated the protein level of lin-28 homolog B (LIN28B) via a direct interaction. A higher expression level of LINC00467 was observed in breast cancer tissues as compared to the adjacent normal counterparts and elevated LINC00467 predicted poor overall survival. Our findings suggest LINC00467 promotes progression of breast cancer through interacting with miR-138-5p and LIN28B directly. LINC00467 may serve as a potential candidate for the diagnosis and treatment of breast cancer.

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Long Non-Coding RNA LINC00467 Correlates to Poor Prognosis and Aggressiveness of Breast Cancer

et al. 2021

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“…212 lncRNA LINC00668 is upregulated in breast cancer cells and improves DOX resistance by targeting staphylococcal nuclease domain-containing 1 (SND1). 213 Contrary to positive regulation of above lncRNAs in breast cancer resistance to anthracycline, some lncRNAs can reduce the drug resistance. lncRNA PTENP1 is downregulated in breast cancer cells and tissues.…”

Section: Lncrnas Mediate Breast Cancer Invasion and Metastasismentioning

confidence: 99%

“… 212 lncRNA LINC00668 is upregulated in breast cancer cells and improves DOX resistance by targeting staphylococcal nuclease domain-containing 1 (SND1). 213 …”

Section: The Role Of Lncrna In Breast Cancer Malignant Progressmentioning

confidence: 99%

lncRNA and breast cancer: Progress from identifying mechanisms to challenges and opportunities of clinical treatment

Jin

Huang

et al. 2021

Molecular Therapy - Nucleic Acids

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Breast cancer is a malignant tumor that has a high mortality rate and mostly occurs in women. Although significant progress has been made in the implementation of personalized treatment strategies for molecular subtypes in breast cancer, the therapeutic response is often not satisfactory. Studies have reported that long non-coding RNAs (lncRNAs) are abnormally expressed in breast cancer and closely related to the occurrence and development of breast cancer. In addition, the high tissue and cell-type specificity makes lncRNAs particularly attractive as diagnostic biomarkers, prognostic factors, and specific therapeutic targets. Therefore, an in-depth understanding of the regulatory mechanisms of lncRNAs in breast cancer is essential for developing new treatment strategies. In this review, we systematically elucidate the general characteristics, potential mechanisms, and targeted therapy of lncRNAs and discuss the emerging functions of lncRNAs in breast cancer. Additionally, we also highlight the advantages and challenges of using lncRNAs as biomarkers for diagnosis or therapeutic targets for drug resistance in breast cancer and present future perspectives in clinical practice.Long non-coding RNAs (lncRNAs) are originally thought to be the noise of transcripts in the genome and have no biological function. Recently, the function of lncRNAs is beginning to attract widespread attention. 7 Increasing studies have shown that lncRNAs are involved in various aspects of cellular physiological processes, such as proliferation, differentiation, migration, and apoptosis, by regulating gene transcription and post-transcriptional processing. 8,9 In addition, lncRNAs are closely related to the occurrence, development, and prognosis of various cancers, such as breast, liver, colon, and lung cancer and even leukemia. [10][11][12][13] According to lncRNA genomic position, subcellular localization, and function, they can be divided into six types (Figure 1). 14 (1) Enhancer lncRNAs are derived from the promoter enhancer region, such as lncRNA-LEENE. 15 (2) Intron lncRNAs are transcribed from the intron region of the gene. The gene-coding protein completely contained the intron lncRNA, which can stabilize the transcription or regulate the alternative splicing of the coding gene. (3) Antisense lncRNA: its transcription orientation is opposite to the transcription orientation of the adjacent protein-encoding gene, such as lncTALAM1 and PDCD4-AS1. 16,17 (4) The sense lncRNA: its transcription orientation is the same as that of the adjacent protein-encoding gene, such as lncRNAGAS5 and ecCEPBA. 18,19 (5) Intergenic lncRNA, which can be transcribed between two protein-coding genes, is an autonomously transcribed

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“…It has been reported that there is a correlation between linc00668 upregulation and lymph node metastasis in BC patients. Linc00668 induces cell invasion, self-renewal properties, and DOX resistance in BC cells through SND1 binding to upregulate SMAD2/3/4 [ 54 ].…”

Section: Introductionmentioning

confidence: 99%

Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells

Khalili-Tanha

Moghbeli

2021

Cell Mol Biol Lett

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Resistance against conventional chemotherapeutic agents is one of the main reasons for tumor relapse and poor clinical outcomes in cancer patients. Various mechanisms are associated with drug resistance, including drug efflux, cell cycle, DNA repair and apoptosis. Doxorubicin (DOX) is a widely used first-line anti-cancer drug that functions as a DNA topoisomerase II inhibitor. However, DOX resistance has emerged as a large hurdle in efficient tumor therapy. Furthermore, despite its wide clinical application, DOX is a double-edged sword: it can damage normal tissues and affect the quality of patients’ lives during and after treatment. It is essential to clarify the molecular basis of DOX resistance to support the development of novel therapeutic modalities with fewer and/or lower-impact side effects in cancer patients. Long non-coding RNAs (lncRNAs) have critical roles in the drug resistance of various tumors. In this review, we summarize the state of knowledge on all the lncRNAs associated with DOX resistance. The majority are involved in promoting DOX resistance. This review paves the way to introducing an lncRNA panel marker for the prediction of the DOX response and clinical outcomes for cancer patients.

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Linc00668 Promotes Invasion and Stem Cell-Like Properties of Breast Cancer Cells by Interaction With SND1

Cited by 15 publications

References 54 publications

Long Non-Coding RNA LINC00467 Correlates to Poor Prognosis and Aggressiveness of Breast Cancer

Long Non-Coding RNA LINC00467 Correlates to Poor Prognosis and Aggressiveness of Breast Cancer

lncRNA and breast cancer: Progress from identifying mechanisms to challenges and opportunities of clinical treatment

Long non-coding RNAs as the critical regulators of doxorubicin resistance in tumor cells

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