LINC00662: A new oncogenic lncRNA with great potential

Zhong, Chenming; Zhang, Qiudan; Zhang, Mingfang; Qi, Yuanlin; Duan, Shiwei

doi:10.1002/jcp.30599

Cited by 9 publications

(6 citation statements)

References 29 publications

(135 reference statements)

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“…The result was the same as the tendency of prior studies [25,26]. Elevation of LncRNA is closely correlated to the poor prognosis of patients with cancer and resistance in radio-/chemo-therapy [27]. We speculated that lncRNA CRNDE may be correlated with radiosensitivity in HCC.…”

Section: Discussionsupporting

confidence: 86%

LncRNA CRNDE is involved in radiation resistance in hepatocellular carcinoma via modulating the SP1/PDK1 axis

Chen¹,

Zhu²,

He³

et al. 2022

neo

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Hepatocellular carcinoma (HCC) is defined as a universal malignancy while radiation therapy is the effective treatment for it. This study validated the mechanism of long non-coding RNA (lncRNA) colorectal neoplasia differentially expressed gene (CRNDE) in radiation resistance in HCC. LncRNA CRNDE upregulation was detected in HCC cells. The radiation-resistant cell strains Huh7R and SNU-387R were established. After silencing lncRNA CRNDE, the cell colony -H2AX positive rate in Huh7R and SNU-387R were detected. Silencing lncRNA CRNDE decreased the cell activity, colony formation ability, and cell number in the G2 phase and facilitated DNA damage and apoptosis. The binding relations of specificity protein 1 (SP1) with lncRNA CRNDE and 3-phosphoinositide dependent protein kinase 1 (PDK1) were verified. LncRNA CRNDE regulated PDK1 transcription by binding to transcription factor SP1. PDK1 overexpression partially reversed the inhibition of silencing lncRNA CRNDE on radiation resistance in HCC cells. The transplanted tumor mouse model was established and showed that silencing lncRNA CRNDE decreased tumor volume and weight and Ki67-positive cells in HCC mice in vivo. Collectively, lncRNA CRNDE was upregulated in HCC cells and promoted PDK1 transcription by binding to SP1, thus enhancing radiation resistance in HCC cells.

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Section: Discussionsupporting

confidence: 86%

LncRNA CRNDE is involved in radiation resistance in hepatocellular carcinoma via modulating the SP1/PDK1 axis

Chen¹,

Zhu²,

He³

et al. 2022

neo

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“…The biological functions of LINC00662 in several human cancers have been demonstrated recently. LINC00662 is highly expressed and promotes malignant progression in several types of cancer, including gastric cancer, lung cancer, and oral squamous cell carcinoma [ 13 , 31 ]. Previous studies demonstrated the possibility of LINC00662 as a therapeutic target for chordoma, lung cancer and breast cancer [ 13 ].…”

Section: Discussionmentioning

confidence: 99%

PITX1 suppresses osteosarcoma metastasis through exosomal LINC00662-mediated M2 macrophage polarization

Zhang

Chen

et al. 2022

Clin Exp Metastasis

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Paired-like homeodomain transcription factor 1 (PITX1) is frequently downregulated in cancers, including osteosarcoma (OS). However, its role in OS remains unknown. Therefore, we aimed to explore the functions and potential mechanisms of PITX1 in OS malignant progression. Elevated PITX1 suppressed OS cell proliferation and migration, based on transwell, proliferation, and colony formation assays. Pathway enrichment analysis of differentially-expressed genes between PITX1-overexpressing and control OS cells indicated that PITX1 expression was associated with the FAK/Src and PI3k/Akt signaling pathways. Mechanistically, ubiquitination assays and rescue experiments showed that PITX1 interacted with transcription factor STAT3, leading to decreased STAT3 transcriptional activity, which repressed the expression of LINC00662. Specific knockdown of LINC00662 reduced the tumor growth and invasion of OS cells induced by downregulated PITX1. Moreover, exosomal LINC00662, derived from PITX1 knockdown OS cell lines activated M2 macrophages in cell co-culture assays. M2 macrophage secreted several cytokines, among which CCL22 was found to cause OS cell EMT. Collectively, our data indicate that PITX1 suppresses OS cell proliferation and metastasis by downregulating LINC00662. Moreover, LINC00662 can be packaged into OS cell-derived exosomes to mediate M2 macrophage polarization to promote OS metastasis via CCL22.

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“…LINC00662 is located on chromosome 19q11 and is 2085 bp long. LINC00662 is upregulated in a variety of malignant tumors, and the upregulated expression of LINC00662 is also closely related to the poor prognosis, radioresistance and chemoresistance of cancer patients ( 102 , 103 ). The expression of LINC00662 was shown to be significantly upregulated in cervical cancer tissues and cells, and the high expression of LINC00662 resulted in reduced overall survival and relapse-free survival, and was associated with FIGO stage and lymph node metastasis.…”

Section: The Role Of Lncrnas In Regulating Radiosensitivity Of Cervic...mentioning

confidence: 99%

The Role of LncRNAs in the Regulation of Radiotherapy Sensitivity in Cervical Cancer

et al. 2022

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Cervical cancer (CC) is one of the three majors gynecological malignancies, which seriously threatens women’s health and life. Radiotherapy (RT) is one of the most common treatments for cervical cancer, which can reduce local recurrence and prolong survival in patients with cervical cancer. However, the resistance of cancer cells to Radiotherapy are the main cause of treatment failure in patients with cervical cancer. Long non-coding RNAs (LncRNAs) are a group of non-protein-coding RNAs with a length of more than 200 nucleotides, which play an important role in regulating the biological behavior of cervical cancer. Recent studies have shown that LncRNAs play a key role in regulating the sensitivity of radiotherapy for cervical cancer. In this review, we summarize the structure and function of LncRNAs and the molecular mechanism of radiosensitivity in cervical cancer, list the LncRNAs associated with radiosensitivity in cervical cancer, analyze their potential mechanisms, and discuss the potential clinical application of these LncRNAs in regulating radiosensitivity in cervical cancer.

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LINC00662: A new oncogenic lncRNA with great potential

Cited by 9 publications

References 29 publications

LncRNA CRNDE is involved in radiation resistance in hepatocellular carcinoma via modulating the SP1/PDK1 axis

LncRNA CRNDE is involved in radiation resistance in hepatocellular carcinoma via modulating the SP1/PDK1 axis

PITX1 suppresses osteosarcoma metastasis through exosomal LINC00662-mediated M2 macrophage polarization

The Role of LncRNAs in the Regulation of Radiotherapy Sensitivity in Cervical Cancer

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