Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis

Liang, Yin; Xu, Xiao-Dan; Xu, Xi; Cai, Yang-Bo; Zhu, Zi-Xian; Zhu, Lin; Ren, Kun

doi:10.1016/j.ijbiomac.2023.126953

Cited by 3 publications

(3 citation statements)

References 52 publications

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Section: Cell Death In Atherosclerotic Plaques: Pyroptosis Necroptosi...mentioning

confidence: 99%

“…Recently, it was described that long non-coding RNAs (lncRNAs) can be involved in the regulation of oxLDL-induced pyroptosis ( 161 , 162 ). Indeed, both linc00657 ( 161 ) and AC078850.1 ( 162 ) potentiated pyroptosis in THP-1-derived macrophages. Interestingly, the latter molecule acted ( 161 ) in conjunction with hypoxia-inducible factor 1-alpha (HIF-1α) to promote NLRP3-mediated pyroptosis and foam cell formation in atherosclerosis cases ( 162 ).…”

Section: Cell Death In Atherosclerotic Plaques: Pyroptosis Necroptosi...mentioning

confidence: 99%

“…Moreover, GSDME deficiency significantly decreases serum levels of inflammatory factors, such as IL-1b, TNFa, and monocyte chemoattractant protein-1 (MCP-1), resulting in the suppression of both inflammation and disease development (145). Recently, it was described that long non-coding RNAs (lncRNAs) can be involved in the regulation of oxLDL-induced pyroptosis (161,162). Indeed, both linc00657 (161) and AC078850.1 (162) potentiated pyroptosis in THP-1-derived macrophages.…”

Section: Oxldl-induced Pyroptosis In Macrophagesmentioning

confidence: 99%

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The dance of macrophage death: the interplay between the inevitable and the microenvironment

Makuch,

Stepanechko,

Bzowska

2024

Front. Immunol.

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Macrophages are highly plastic cells ubiquitous in various tissues, where they perform diverse functions. They participate in the response to pathogen invasion and inflammation resolution following the immune response, as well as the maintenance of homeostasis and proper tissue functions. Macrophages are generally considered long-lived cells with relatively strong resistance to numerous cytotoxic factors. On the other hand, their death seems to be one of the principal mechanisms by which macrophages perform their physiological functions or can contribute to the development of certain diseases. In this review, we scrutinize three distinct pro-inflammatory programmed cell death pathways – pyroptosis, necroptosis, and ferroptosis – occurring in macrophages under specific circumstances, and explain how these cells appear to undergo dynamic yet not always final changes before ultimately dying. We achieve that by examining the interconnectivity of these cell death types, which in macrophages seem to create a coordinated and flexible system responding to the microenvironment. Finally, we discuss the complexity and consequences of pyroptotic, necroptotic, and ferroptotic pathway induction in macrophages under two pathological conditions – atherosclerosis and cancer. We summarize damage-associated molecular patterns (DAMPs) along with other microenvironmental factors, macrophage polarization states, associated mechanisms as well as general outcomes, as such a comprehensive look at these correlations may point out the proper methodologies and potential therapeutic approaches.

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Section: Cell Death In Atherosclerotic Plaques: Pyroptosis Necroptosi...mentioning

confidence: 99%

Section: Cell Death In Atherosclerotic Plaques: Pyroptosis Necroptosi...mentioning

confidence: 99%

Section: Oxldl-induced Pyroptosis In Macrophagesmentioning

confidence: 99%

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The dance of macrophage death: the interplay between the inevitable and the microenvironment

Makuch,

Stepanechko,

Bzowska

2024

Front. Immunol.

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Genome-wide transcriptional profiling and functional analysis of long noncoding RNAs and mRNAs in chicken macrophages associated with the infection of avian pathogenic E. coli

Sun,

Cao,

Sumayya

et al. 2024

BMC Vet Res

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Background Avian pathogenic E. coli (APEC) can cause localized or systemic infections, collectively known as avian colibacillosis, resulting in huge economic losses to poultry industry globally per year. In addition, increasing evidence indicates that long non-coding RNAs (lncRNAs) play a critical role in regulating host inflammation in response to bacterial infection. However, the role of lncRNAs in the host response to APEC infection remains unclear. Results Here, we found 816 differentially expressed (DE) lncRNAs and 1,798 DE mRNAs in APEC infected chicken macrophages by RNAseq. The identified DE lncRNA-mRNAs were involved in Toll like receptor signaling pathway, VEGF signaling pathway, fatty acid metabolism, phosphatidylinositol signaling system, and other types of O-glycan biosynthesis. Furthermore, we found the novel lncRNA TCONS_00007391 as an important immune regulator in APEC infection was able to regulate the inflammatory response by directly targeting CD86. Conclusion These findings provided a better understanding of host response to APEC infection and also offered the potential drug targets for therapy development against APEC infection.

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Long Non-Coding RNAs in Kidney Injury: A Comprehensive Review

Bhat,

Shanbhag

2024

JPDMHD

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Kidney injury, a global health challenge, necessitates a nuanced understanding of molecular intricacies for effective interventions. Long non-coding RNAs (lncRNAs), once dismissed as transcriptional noise, now emerge as pivotal players in orchestrating renal health. Dysregulation of specific lncRNAs like TUG1, MALAT1, H19, and NEAT1 provides molecular signatures, distinguishing physiological states from pathological conditions. In acute kidney injury (AKI), TUG1 and MALAT1 regulate apoptosis, inflammation, and fibrosis. Chronic kidney disease (CKD) involves lncRNAs like H19 and NEAT1 modulating cell proliferation and apoptosis. Beyond diagnostics, lncRNAs actively shape inflammation, apoptosis, and fibrosis, positioning them as master regulators in the intricate ballet of kidney health. Recent strides in research, coupled with cutting-edge genomics and bioinformatics tools, highlight their roles and therapeutic potential. Challenges in understanding their intricate roles and interactions necessitate the exploration of promising avenues, including single-cell RNA sequencing and artificial intelligence, paving the way for personalized interventions and regenerative medicine in kidney diseases.

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Linc00657 promoted pyroptosis in THP-1-derived macrophages and exacerbated atherosclerosis via the miR-106b-5p/TXNIP/NLRP3 axis

Cited by 3 publications

References 52 publications

The dance of macrophage death: the interplay between the inevitable and the microenvironment

The dance of macrophage death: the interplay between the inevitable and the microenvironment

Genome-wide transcriptional profiling and functional analysis of long noncoding RNAs and mRNAs in chicken macrophages associated with the infection of avian pathogenic E. coli

Long Non-Coding RNAs in Kidney Injury: A Comprehensive Review

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