LINC00630 promotes cholangiocarcinoma cell proliferation, migration and invasion by mediating the miR-199a/FGF7 axis

Abstract

Cholangiocarcinoma (CCA) is a type of cancer with a relatively low morbidity, but poor prognosis. Aberrant long non-coding RNA (lncRNA) expression has been observed in the pathological development of CCA. In the present study, lncRNA long intergenic non-protein coding RNA 630 (LINC00630) was found to be significantly upregulated in CCA tissues and cultured cells. LINC00630 expression was positively associated with histological differentiation, TNM stage and lymph node invasion. Short hairpin RNA (sh)-LINC00630 transfection could effectively decrease CCA cell proliferation, migration and invasion. Further investigations found that LINC00630 could interact with microRNA (miR)-199a, which specifically targeted fibroblast growth factor 7 (FGF7) for degradation. FGF7 overexpression restored the sh-LINC00630 transfection-induced decrease in CCA cell proliferation, migration and invasion. In conclusion, LINC00630 significantly promoted CCA cell proliferation, migration and invasion by upregulating FGF7 through miR-199a sponging.

Naringenin induces the cell apoptosis of acute myeloid leukemia cells by regulating the lncRNA XIST/miR-34a/HDAC1 signaling

“…LncRNAs play a critical role in the pathological development of various diseases, including malignant tumors [ 39 ]. It has been demonstrated that lncRNA LINC00630 can effectively inhibit the proliferation, migration, and invasion of cholangiocarcinoma cells by mediating the miR-199a/FGF7 axis [ 40 ]. LncRNA HOX transcript antisense RNA has been reported to play an important role in the progression of osteoarthritis, and it enhances mechanical stimulation-induced chondrocyte apoptosis by mediating the miR-221/BBC3 axis in C28/I2 cells [ 41 ].…”