LINC00511/hsa-miR-573 axis-mediated high expression of Gasdermin C associates with dismal prognosis and tumor immune infiltration of breast cancer

Sun, Kai; Chen, Rixin; Li, Jingzhang; Luo, Zuojie

doi:10.1038/s41598-022-19247-9

Cited by 12 publications

(4 citation statements)

References 69 publications

(84 reference statements)

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“…However, pyroptosis does not exert an absolutely positive therapeutic anticancer effect. A study revealed that elevated expression of GSDMC is also strongly associated with a worse prognosis for invasive breast carcinoma patients and exhibits a correlation with immune cell infiltration in the tumor [122]. Jianwei Gao and colleagues also found that increased GSDMD expression levels may increase the tumor size, promote more advanced tumornode-metastasis stages, and affect survival rates.…”

Section: Pyroptosis In Proliferation and Metastasismentioning

confidence: 99%

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

et al. 2022

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Many types of human cells self-destruct to maintain biological homeostasis and defend the body against pathogenic substances. This process, called regulated cell death (RCD), is important for various biological activities, including the clearance of aberrant cells. Thus, RCD pathways represented by apoptosis have increased in importance as a target for the development of cancer medications in recent years. However, because tumor cells show avoidance to apoptosis, which causes treatment resistance and recurrence, numerous studies have been devoted to alternative cancer cell mortality processes, namely necroptosis, pyroptosis, ferroptosis, and cuproptosis; these RCD modalities have been extensively studied and shown to be crucial to cancer therapy effectiveness. Furthermore, evidence suggests that tumor cells undergoing regulated death may alter the immunogenicity of the tumor microenvironment (TME) to some extent, rendering it more suitable for inhibiting cancer progression and metastasis. In addition, other types of cells and components in the TME undergo the abovementioned forms of death and induce immune attacks on tumor cells, resulting in enhanced antitumor responses. Hence, this review discusses the molecular processes and features of necroptosis, pyroptosis, ferroptosis, and cuproptosis and the effects of these novel RCD modalities on tumor cell proliferation and cancer metastasis. Importantly, it introduces the complex effects of novel forms of tumor cell death on the TME and the regulated death of other cells in the TME that affect tumor biology. It also summarizes the potential agents and nanoparticles that induce or inhibit novel RCD pathways and their therapeutic effects on cancer based on evidence from in vivo and in vitro studies and reports clinical trials in which RCD inducers have been evaluated as treatments for cancer patients. Lastly, we also summarized the impact of modulating the RCD processes on cancer drug resistance and the advantages of adding RCD modulators to cancer treatment over conventional treatments.

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Section: Pyroptosis In Proliferation and Metastasismentioning

confidence: 99%

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

et al. 2022

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“…Recent studies have shown 28 that GSDMC and PD-L1 can cause BC tissue necrosis by transforming apoptosis into pyroptosis under hypoxic conditions. In addition, Sun et al 45 revealed that high expression of GSDMC leads to poor prognosis and tumour immune invasion in BC. CASP9 is an essential therapeutic target for various apoptosis-related diseases, including cancer.…”

Section: Discussionmentioning

confidence: 99%

“…In addition, Sun et al. 45 revealed that high expression of GSDMC leads to poor prognosis and tumour immune invasion in BC. CASP9 is an essential therapeutic target for various apoptosis‐related diseases, including cancer.…”

Section: Discussionmentioning

confidence: 99%

Development and validation of stable ferroptosis‐ and pyroptosis‐related signatures in predicting prognosis and immune status in breast cancer

Zhou,

Wong,

Liu

et al. 2023

J Cellular Molecular Medi

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To develop and validate the predictive effects of stable ferroptosis‐ and pyroptosis‐related features on the prognosis and immune status of breast cancer (BC). We retrieved as well as downloaded ferroptosis‐ and pyroptosis‐related genes from the FerrDb and GeneCards databases. The minimum absolute contraction and selection operator (LASSO) algorithm in The Cancer Genome Atlas (TCGA) was used to construct a prognostic classifier combining the above two types of prognostic genes with differential expression, and the Integrated Gene Expression (GEO) dataset was used for validation. Seventeen genes presented a close association with BC prognosis. Thirteen key prognostic genes with prognostic value were considered to construct a new expression signature for classifying patients with BC into high‐ and low‐risk groups. Kaplan–Meier analysis revealed a worse prognosis in the high‐risk group. The receiver operating characteristic (ROC) curve and multivariate Cox regression analysis identified its predictive and independent features. Immune profile analysis showed that immunosuppressive cells were upregulated in the high‐risk group, and this risk model was related to immunosuppressive molecules. We successfully constructed combined features of ferroptosis and pyroptosis in BC that are closely related to prognosis, clinicopathological and immune features, chemotherapy efficacy and immunosuppressive molecules. However, further experimental studies are required to verify these findings.

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“…Xu et al ( 34 ) also found that GSDMC may be a risk factor for breast cancer prognosis. Sun et al ( 35 ) showed that the LINC00511/hsa-miR-573 axis could regulate the high expression level of GSDMC and that upregulated GSDMC was associated with a poor prognosis in patients with breast cancer. Zhang et al ( 36 ) showed that the oxidation of plasma membrane-localized death receptor 6 was induced by the enhancement of ROS and recruited both pro-caspase-8 and GSDMC to the cytosol, which activated GSDMC cleavage by caspase-8, thus inducing pyroptosis.…”

Section: Gsdmcmentioning

confidence: 99%

Role of gasdermin family proteins in cancers (Review)

Yang

Tang

2023

Int J Oncol

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The gasdermin (GSDM) family comprises six proteins, including GSDMA-GSDME and Pejvakin. Most of these proteins have a crucial role in inducing pyroptosis; in particular, GSDMD and GSDME are the most extensively studied proteins as the executioners of the pyroptosis process. Pyroptosis is a highly pro-inflammatory form of programmed cell death and is closely associated with the incidence, development and prognosis of multiple cancer types. The present review focused on the current knowledge of the molecular mechanism of GSDM-mediated pyroptosis, its intricate role in cancer and the potential therapeutic value of its anti-tumor effects.

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LINC00511/hsa-miR-573 axis-mediated high expression of Gasdermin C associates with dismal prognosis and tumor immune infiltration of breast cancer

Cited by 12 publications

References 69 publications

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

Targeting cell death pathways for cancer therapy: recent developments in necroptosis, pyroptosis, ferroptosis, and cuproptosis research

Development and validation of stable ferroptosis‐ and pyroptosis‐related signatures in predicting prognosis and immune status in breast cancer

Role of gasdermin family proteins in cancers (Review)

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