LINC00261 suppresses cell proliferation, invasion and Notch signaling pathway in hepatocellular carcinoma

Zhang, Haifeng; Li, Wei; Han, Yidi

doi:10.3233/cbm-170471

Cited by 48 publications

(52 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although our data showed similar LINC00261 functions on cancer cell aggressiveness as reported previously, 15,[17][18][19]23 the molecular mechanisms are totally different. In colon cancer, LINC00261 downregulates Wnt signalling activity through restraining β-catenin from cytoplasm into nuclei and promoting β-catenin degradation.…”

Section: Discussionsupporting

confidence: 85%

“…Now, we first time reported that LINC00261 was also downregulated in endometrial carcinoma, and the LINC00261 levels were further decreased in endometrial carcinoma with lymphatic metastasis. Although our data showed similar LINC00261 functions on cancer cell aggressiveness as reported previously, the molecular mechanisms are totally different. In colon cancer, LINC00261 downregulates Wnt signalling activity through restraining β‐catenin from cytoplasm into nuclei and promoting β‐catenin degradation .…”

Section: Discussionsupporting

confidence: 83%

“…LINC00261 has been reported to be downregulated in multiple cancers, including colon cancer, 23 stomach cancer, 24 gastric cancer, 15,25 nonsmall cell lung cancer, 18 and hepatocellular cancer. 19 Now, we first time reported that LINC00261 was also downregulated in endometrial carcinoma, and the LINC00261 levels were further decreased in endometrial carcinoma with lymphatic metastasis.…”

Section: Discussionmentioning

confidence: 94%

“…18 In hepatocellular carcinoma, LINC00261 impedes cell proliferation and invasion by blocking Notch signalling pathway. 19 However, expression and functions of LINC00261 in endometrial cancer have not been defined.…”

mentioning

confidence: 99%

See 3 more Smart Citations

Long noncoding RNA LINC00261 regulates endometrial carcinoma progression by modulating miRNA/FOXO1 expression

Fang

Sang

2018

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 85%

Section: Discussionsupporting

confidence: 83%

Section: Discussionmentioning

confidence: 94%

mentioning

confidence: 99%

See 2 more Smart Citations

Long noncoding RNA LINC00261 regulates endometrial carcinoma progression by modulating miRNA/FOXO1 expression

Fang

Sang

2018

Cell Biochemistry & Function

View full text Add to dashboard Cite

show abstract

“…Host genes may affect small nucleolar RNAs (snoRNAs) expression through co-transcriptional regulation [44]; snoRNAs are non-coding RNAs of 60-300 nucleotides in length [45]. Up-regulated LINC00261 has also been reported to suppress the proliferation and invasion of HCC cells [46]. These basic findings may, in part, hint that snoRNA host genes may have a profound impact on the prognosis of HCC, emphasizing that the prognostic value of lncRNAs warrants future research.…”

mentioning

confidence: 99%

Genome-Wide Analysis of Prognostic lncRNAs, miRNAs, and mRNAs Forming a Competing Endogenous RNA Network in Hepatocellular Carcinoma

Lin

Wen

et al. 2018

Cell Physiol Biochem

View full text Add to dashboard Cite

Background/Aims: Hepatocellular carcinoma (HCC) is the most prevalent subtype of primary liver tumor worldwide. Growing evidence has led to a consensus that long non-coding RNAs (lncRNAs) have considerable influence on tumorigenesis and tumor progression of HCC via the mechanism of competing endogenous RNAs (ceRNAs). Methods: Here, we systematically investigated the expression landscape and clinical prognostic value of lncRNAs, micorRNAs (miRNAs), and mRNAs from The Cancer Genome Atlas. Differentially expressed RNAs were submitted to Cox regression analysis and the construction of prognostic indexes. A lncRNA-miRNA-mRNA regulatory network was then constructed based on interaction information derived from miRcode, TargetScan, miRTarBase, and miRDB. Gene Ontology and Kyoto Encyclopedia of Genes and Genomes analyses were performed to reveal and determine the functional roles of the ceRNA network in the prognosis of HCC. Results: We detected 77 differentially expressed lncRNAs, 29 differentially expressed miRNAs, and 1014 differentially expressed mRNAs in HCC, which were significantly associated with the overall survival of patients with HCC. We developed three prognostic prediction models that showed moderate predicting prognosis performance and were highly correlated with tumor burden, histological grade and pathological stage. Additionally, 10 survival-related lncRNAs, 6 survival-related miRNAs, and 31 survival-related mRNAs were included to develop a ceRNA network. Further functional enrichment analysis suggested that the ceRNA network was associated with a dismal prognosis for patients with HCC by disturbing the homeostasis of the cell cycle. Conclusion: Together, our study highlights the significant roles of lncRNAs in the development and implementation of monitoring surveillance and prognosis of HCC and provides a deeper understanding of the lncRNA-related ceRNA regulatory mechanism in the pathogenesis of HCC.

show abstract

Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges

Yang

Deng

et al. 2020

Cancer Communications

View full text Add to dashboard Cite

Cholangiocarcinoma (CCA), a cancer with a relatively low incidence rate, is usually associated with poor prognosis. Current modalities for the diagnosis and treatment of CCA patients are still far from satisfactory. In recent years, numerous long noncoding RNAs (lncRNAs) have been identified as crucial players in the development of various cancers, including CCA. Abnormally expressed lncRNAs in CCA, regulated by some upstream molecules, significantly influence the biological behavior of tumor cells and are involved in tumor development through various mechanisms, including interactions with functional proteins, participation in competing for endogenous RNA (ceRNA) regulatory networks, activation of cancer‐related signaling pathways and epigenetic modification of gene expression. Furthermore, several lncRNAs are closely associated with the clinicopathological features of CCA patients, and are promising biomarkers for diagnosing and prognostication of CCA. Some of these lncRNAs play an important role in chemotherapy drug resistance. In addition, lncRNAs have also been shown to be involved in the inflammation microenvironment of CCA and malignant outcome of CCA risk factors, such as cholestatic liver diseases. In view of the difficulty of diagnosing CCA, more attention should be paid to detectable lncRNAs in the serum or bile. This review summarizes the recent knowledge on lncRNAs in CCA and provides a new outlook on the molecular mechanisms of CCA development from the perspective of lncRNAs. Moreover, we also discussed the limitations of the current studies and differential expression of lncRNAs in different types of CCA.

show abstract

LINC00261 suppresses cell proliferation, invasion and Notch signaling pathway in hepatocellular carcinoma

Abstract: These results indicated that LINC00261 may be a potential target of HCC treatment.

Cited by 48 publications

References 20 publications

Long noncoding RNA LINC00261 regulates endometrial carcinoma progression by modulating miRNA/FOXO1 expression

Long noncoding RNA LINC00261 regulates endometrial carcinoma progression by modulating miRNA/FOXO1 expression

Genome-Wide Analysis of Prognostic lncRNAs, miRNAs, and mRNAs Forming a Competing Endogenous RNA Network in Hepatocellular Carcinoma

Emerging roles of long noncoding RNAs in cholangiocarcinoma: Advances and challenges

Contact Info

Product

Resources

About