LINC00240 knockdown inhibits nasopharyngeal carcinoma progress by targeting miR‐26a‐5p

Chen, Xing; Wu, Guixiang; Jing, Qing; Li, Chunlin; Chen, Xudong; Shen, Jian

doi:10.1002/jcla.24424

Cited by 8 publications

(7 citation statements)

References 35 publications

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“…Nasopharyngeal carcinoma (NPC), which originates from nasopharyngeal epithelial cells, 1,2 is one of the most common types of head and neck cancer in parts of Southeast Asia, Southern China, and North Africa, with 5‐year survival rates of 70%–80% 3,4 . Distant metastasis and local and regional recurrences that affect the long‐term survival of patients are the primary reasons for treatment failure 5 . According to statistics, local recurrence occurs in 5%–10% of patients and distant metastasis occurs in 10%–20% of patients after treatment 6 .…”

Section: Introductionmentioning

confidence: 99%

Recommendation for imaging follow‐up strategy based on time‐specific disease failure for nasopharyngeal carcinoma

et al. 2022

Head & Neck

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Background To develop a common follow‐up strategy for appropriate imaging examination at an appropriate time for nasopharyngeal carcinoma (NPC). Methods Independent prognostic factors were identified by Cox regression analysis, and a nomogram model was developed. Random survival forest (RSF) model was constructed to depict probability of disease failure during a 5‐year follow‐up and establish a reasonable risk‐based follow‐up strategy. Results The nomogram model finally categorized the patients into three risk groups. RSF model demonstrated distribution trends for local and regional recurrences, bone metastasis, liver metastasis, and lung metastasis of NPC. Adequate imaging at follow‐up should be considered between 10 and 21 months for patients at moderate‐risk of recurrence or metastasis and 7–36 months for those at high‐risk. Conclusions The temporal distribution of incidence rates of recurrence or metastasis varied among different risk groups. We recommend implementing a focused and targeted imaging surveillance intervention at appropriate times to improve its efficiency and reduce costs.

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Section: Introductionmentioning

confidence: 99%

Recommendation for imaging follow‐up strategy based on time‐specific disease failure for nasopharyngeal carcinoma

et al. 2022

Head & Neck

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“…Recent microarray analyses have discovered a number of dysregulated lncRNAs in AR which might be associated with allergic inflammation [12,30,31], however, the mechanisms by which these altered lncRNAs contribute to AR pathogenesis merit in-depth investigation. Several studies have illustrated the critical roles of LINC00240 in cancer biology, and identified related ceRNA networks in different cancers [13][14][15][16][17]. For instance, silencing of LINC00240 suppresses cell growth, metastasis and angiogenesis via miR-26a-5p in NPC [17].…”

Section: Discussionmentioning

confidence: 99%

“…Several studies have illustrated the critical roles of LINC00240 in cancer biology, and identified related ceRNA networks in different cancers [13][14][15][16][17]. For instance, silencing of LINC00240 suppresses cell growth, metastasis and angiogenesis via miR-26a-5p in NPC [17]. Our preliminary bioinformatics analysis showed reduced expression of LINC00240 in AR patients, and this data was verified by qRT-PCR in the peripheral blood and nasal mucosa of AR patients, as well as in the nasal mucosa of AR mice.…”

Section: Discussionmentioning

confidence: 99%

“…Long non-coding RNAs (lncRNAs) serve as critical regulators in a variety of biological processes and implicated in different diseases, such as cancer, diabetes and AR [11,12]. Recently, several studies have demonstrated the aberrant expression of LINC00240 in non-small cell lung cancer (NSCLC), gastric cancer (GC), nasopharyngeal carcinoma (NPC), cervical cancer and hepatocellular carcinoma (HCC), and it exerts either a pro-or anti-oncogenic role in different cancers [13][14][15][16][17]. However, its function in AR remains uninvestigated.…”

Section: Introductionmentioning

confidence: 99%

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Role of LINC00240 on T-helper 9 differentiation in Allergic Rhinitis through influencing DNMT1-dependent methylation of PU.1

Liu,

Jiang,

Liu

et al. 2023

Preprint

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Background Allergic rhinitis (AR) is a common allergic disease with increasing prevalence globally. However, the molecular mechanism underlying AR pathogenesis remains largely undefined. Methods Samples of peripheral blood and nasal mucosa from patients with AR, as well as the ovalbumin-induced AR mice model was obtained. qRT-PCR and western blot were used to detect the expression of LINC00240, miR-155-5p, PU.1 and other key molecules. ELISA assay and flow cytometry were employed to evaluate the secretion of IL-9 and T-helper 9 (Th9) cell ratio, respectively. Bioinformatics analysis, RNA immunoprecipitation (RIP), chromatin immunoprecipitation (ChIP) and luciferase reporter assays were employed to further elucidate the regulatory network of LINC00240/miR-155-5p/DNMT1. The methylation of PU.1 promoter was assessed by methylation-specific PCR (MSP). This signaling axis was finally confirmed in the AR mice model. Results LINC00240 was downregulated, while miR-155-5p and PU.1 were upregulated in the peripheral blood and nasal mucosa of AR patients, as well as in the AR mice. This was accompanied with the increased ratio of Th9 cells and elevated IL-9 secretion. Mechanistically, LINC00240 served as a miR-155-5p sponge, and DNMT1 was a target of miR-155-5p. In addition, DNMT1 mediated the methylation of PU.1 promoter. In vivo studies verified that LINC00240 mitigated AR progression, possibly via miR-155-5p/DNMT1/PU.1-dependent Th9 differentiation. Conclusion In summary, the involvement of LINC00240 in AR pathogenesis is closely associated with Th9 differentiation through modulating DNMT1-dependent methylation of PU.1 by sponging miR-155-5p.

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“…MiR-1297 and miR-26a-5p are other miRNAs that have been studied in cholesteatoma and are widely investigated in oncology. The inhibitory effect of miR-1297 on cancer progression has been observed in various malignant entities [113][114][115][116][117][118][119][120][121][122][123][124]. In addition to its role in tumorigenesis, miR-26a-5p similarly plays an important role in pulmonary fibrosis [125] and Alzheimer's disease [126].…”

Section: Microrna-802mentioning

confidence: 99%

Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review

Dżaman,

Czerwaty,

Reichert

et al. 2023

IJMS

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Cholesteatoma is a temporal bone disease characterized by dysfunctions of keratinocytes. MicroRNAs (miRNAs) are evolutionary conserved noncoding RNAs that regulate mRNA expression. They can be packaged into exosomes and transported to target cells that can be used in the future therapy of cholesteatoma. This study aimed to collect knowledge on the role of miRNAs and exosomal miRNAs in cholesteatoma and was conducted according to the PRISMA guidelines for systematic reviews. Four databases were screened: Pubmed/MEDLINE, Web of Science, Scopus, and the Cochrane Library. The last search was run on the 6th of June 2023. We included full-text original studies written in English, which examined miRNAs in cholesteatoma. The risk of bias was assessed using the Office of Health Assessment and Translation (OHAT) Risk of Bias Rating Tool, modified for the needs of this review. We identified 118 records and included 18 articles. Analyses revealed the downregulation of exosomal miR-17 as well as miR-10a-5p, miR-125b, miR-142-5p, miR34a, miR-203a, and miR-152-5p and the overexpression of exosomal miR-106b-5p as well as miR-1297, miR-26a-5p, miR-199a, miR-508-3p, miR-21-3p, miR-584-5p, and miR-16-1-3p in cholesteatoma. The role of differentially expressed miRNAs in cholesteatoma, including cell proliferation, apoptosis, the cell cycle, differentiation, bone resorption, and the remodeling process, was confirmed, making them a potential therapeutic target in this disease.

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LINC00240 knockdown inhibits nasopharyngeal carcinoma progress by targeting miR‐26a‐5p

Cited by 8 publications

References 35 publications

Recommendation for imaging follow‐up strategy based on time‐specific disease failure for nasopharyngeal carcinoma

Recommendation for imaging follow‐up strategy based on time‐specific disease failure for nasopharyngeal carcinoma

Role of LINC00240 on T-helper 9 differentiation in Allergic Rhinitis through influencing DNMT1-dependent methylation of PU.1

Expression and Regulatory Mechanisms of MicroRNA in Cholesteatoma: A Systematic Review

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