Linarin ameliorates dextran sulfate sodium-induced colitis in C57BL/6J mice via the improvement of intestinal barrier, suppression of inflammatory responses and modulation of gut microbiota

Abstract

Linarin is a natural flavonoid compound found in Chrysanthemum indicum, Mentha species and other plants with various biological activities. The study aimed to investigate the protective effect of linarin supplementation...

Betaine supplementation alleviates dextran sulfate sodium-induced colitis via regulating the inflammatory response, enhancing the intestinal barrier, and altering gut microbiota

“…Growing evidence shows that natural active ingredients, such as plant extracts, polyphenols, fatty acids, and amino acids, can reduce IBD symptoms by interfering with inflammatory pathways. 7,8 For example, plant extracts, such as eugenol, 9 troxerutin 10 and linarin, 11 could alleviate colitis by attenuating colonic inflammation, recovering the intestinal barrier and improving gut microbiota.…”

Microbial Community Variations and Bioconversion Improvements during Soybean-Based Fermentation by Kefir Grains

“…Linear discriminant analysis effect size (LEfSe) and linear discriminant analysis (LDA) were conducted to further investigate and evaluate the differences in the structure of the microbiota in kefir grains and soybean kefir grains ( Figure 6 ) [ 27 ]. The nodes represented in different colors reflect the OTUs with significant differences, and the sizes of the nodes correspond to the relative abundance of OTUs [ 28 , 29 ].…”

Dietary 5-demethylnobiletin attenuated dextran sulfate sodium-induced colitis in mice by inhibiting immune response and regulating gut microbiota

“…In addition, Roseburia , a bacteria that produces SCFAs, may play an essential role in protecting the integrity of the gut barrier and in preventing intestinal inflammation, among others. 55,56 An increase in Lachnospiraceae abundance was observed after the 5DN treatment in LDA analysis. It has been established that Lachnospiraceae is a probiotic that produces short-chain fatty acids, such as butyric acid.…”