Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress

Altınöz, Eyüp; Öner, Zülal; Elbe, Hülya; Üremiş, Nuray; Uremis, Muhammed Mehdi

doi:10.1080/01480545.2021.1894751

Cited by 18 publications

(6 citation statements)

References 38 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The decrease in MDA levels occurs because linalool is able to suppress oxidative stress in the body. Linalool has an antioxidant effect by reducing levels of free radicals in the body, so that the rate of lipid peroxidation decreases (Altinoz et al, 2021). Oxidative stress conditions were returned to neutral by linalool, triggering an increase in SOD.…”

Section: Resultsmentioning

confidence: 99%

Detoxification of Cadmium on Albino Rats (Rattus norvegicus) with Natural Chelator of Fruiting Body Extract of Ganoderma lucidum

Taufiq

Hernayanti²,

Ratnaningtyas³

2023

molekul

View full text Add to dashboard Cite

Cadmium is a heavy metal pollutant sourced from various industries and toxic to the kidneys. Cadmium exposure can be used natural chelator of ethanol extract of the fruiting body of Ganoderma lucidum. The aim of the study was to determine the effect and effective dose of the ethanolic extract of the fruiting body of G. lucidum on reducing the toxicity effect of cadmium in male albino rats (Rattus norvegicus) Wistar strain. The research design was experimental research, which consisted of 5 treatment levels. The research parameters were blood cadmium, β2-microglobulin, malondialdehyde, and superoxide dismutase levels. The ethanolic extract of fruiting body of G. lucidum was tested by gas chromatography-mass spectrometry (GCMS) to determine linalool as active compounds. The results of each parameter had a significant effect, which decreased blood cadmium, β2M and MDA levels, and increased SOD level that linear according to the addition of the dose of ethanol extract of the fruiting body of G. lucidum. Blood cadmium levels with β2M and MDA levels had a positive correlation, while blood cadmium levels with SOD levels had a negative correlation. The dominant compound detected was linalool which has potential as a radical scavenger. The dose of 750 mg.kgBW-1 is the effective dose of the ethanolic extract of fruiting body of G. lucidum based on a decrease in blood cadmium levels (54.10%), β2M (63.94%) and MDA (20.31%), as well as an increase in SOD levels (14.20%) compared to sick control.

show abstract

Section: Resultsmentioning

confidence: 99%

Detoxification of Cadmium on Albino Rats (Rattus norvegicus) with Natural Chelator of Fruiting Body Extract of Ganoderma lucidum

Taufiq

Hernayanti²,

Ratnaningtyas³

2023

molekul

View full text Add to dashboard Cite

show abstract

“…injury by attenuation of oxidative stress and modulation of antioxidant enzymes such as SOD and CAT (Altinoz et al, 2021). Also, linalool exerted protective effects against excitotoxic cell injury mediated by NMDA in the hippocampal slices (Airao et al, 2021;Sabogal-Guáqueta et al, 2019).…”

Section: Discussionmentioning

confidence: 99%

“…Linalool improved renal function following ischemia–reperfusion injury by mitigation of oxidative damage and restoring the activities of anti‐oxidant enzymes (Golmohammadi et al, 2021 ). Linalool also decreased doxorubicin‐induced renal injury by attenuation of oxidative stress and modulation of anti‐oxidant enzymes such as SOD and CAT (Altinoz et al, 2021 ). Also, linalool exerted protective effects against excitotoxic cell injury mediated by NMDA in the hippocampal slices (Airao et al, 2021 ; Sabogal‐Guáqueta et al, 2019 ).…”

Section: Discussionmentioning

confidence: 99%

Linalool attenuated ischemic injury in PC12 cells through inhibition of caspase‐3 and caspase‐9 during apoptosis

Hosseini

Pourheidar

Rajabian

et al. 2022

Food Science & Nutrition

View full text Add to dashboard Cite

show abstract

“…Biochemical methods used in previous studies were employed to determine malondialdehyde (MDA), total antioxidant status (TAS), and total oxidant status (TOS) levels. [ 30,31 ] Biochemical analysis was performed on homogenized tissues in cold phosphate‐buffered saline (pH 7.4). The homogenates were separated in a centrifuge for 25 min at 5000 rpm and 4°C.…”

Section: Methodsmentioning

confidence: 99%

Dexpanthenol exhibits antiapoptotic and anti‐inflammatory effects against nicotine‐induced liver damage by modulating Bax/Bcl‐xL, Caspase‐3/9, and Akt/NF‐κB pathways

Üremiş,

Aslan,

Taşlidere

et al. 2024

J Biochem & Molecular Tox

Self Cite

View full text Add to dashboard Cite

Chronic tobacco use can lead to liver damage and inflammation due to the accumulation of various toxins in the body. This study aimed to investigate the correlation between the molecular mechanisms of nicotine‐induced liver injury, the caspase cascade, and the Akt/NF‐κB signaling pathway, as well as the protective effects of dexpanthenol (DEX). Male rats were subjected to intraperitoneal injections of nicotine at a concentration of 0.5 mg/kg/day and/or DEX at a concentration of 500 mg/kg/day for 8 weeks. After the treatment period, liver function tests were conducted on serum samples, and tissue samples were analyzed for protein levels of Akt, NF‐κB, Bax, Bcl‐xL, Caspase‐3, and Caspase‐9, along with histopathological changes. Additionally, assessments of oxidative stress markers and proinflammatory cytokines were carried out. Nicotine administration led to elevated levels of IL‐6, IL‐1β, MDA, TOS, and oxidative stress index, accompanied by decreased TAS levels. Moreover, nicotine exposure reduced the p‐Akt/Akt ratio, increased NF‐κB, Bax, Caspase‐3, and Caspase‐9 protein levels, and decreased the antiapoptotic protein Bcl‐xL levels. DEX treatment significantly mitigated these effects, restoring the parameters to levels comparable to those of the control group. Nicotine‐induced liver injury resulted in oxidative stress, inflammation, and apoptosis, mediated by Bax/Bcl‐xL, Caspase‐3, Caspase‐9, and Akt/NF‐κB pathways. Conversely, DEX effectively attenuated nicotine‐induced liver injury by modulating apoptosis through NF‐κB, Caspase‐3, Caspase‐9, Bax inhibition, and Bcl‐xL activation.

show abstract

Linalool exhibits therapeutic and protective effects in a rat model of doxorubicin-induced kidney injury by modulating oxidative stress

Cited by 18 publications

References 38 publications

Detoxification of Cadmium on Albino Rats (Rattus norvegicus) with Natural Chelator of Fruiting Body Extract of Ganoderma lucidum

Detoxification of Cadmium on Albino Rats (Rattus norvegicus) with Natural Chelator of Fruiting Body Extract of Ganoderma lucidum

Linalool attenuated ischemic injury in PC12 cells through inhibition of caspase‐3 and caspase‐9 during apoptosis

Dexpanthenol exhibits antiapoptotic and anti‐inflammatory effects against nicotine‐induced liver damage by modulating Bax/Bcl‐xL, Caspase‐3/9, and Akt/NF‐κB pathways

Contact Info

Product

Resources

About