Linagliptin's impact on lymphatic barrier and lymphangiogenesis in oral cancer with high glucose
Hongyu Wang,
Xiao She,
Qiongdong Xu
et al.
Abstract:ObjectivesUncertainties remain regarding the effect of elevated glucose levels on lymphatic metastasis of cancer cells. Our study elucidated the mechanisms linking high glucose to lymphangiogenesis and lymphatic barrier‐related factors and investigated the protective role of linagliptin against lymphatic barrier dysfunction.Materials and MethodsA CAL‐27‐LEC co‐culture system was established. Sodium fluorescein permeability assay observed lymphatic endothelial cell permeability. Western blotting and RT‐qPCR det… Show more
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