LIN28A-stabilized FBXL19-AS1 promotes breast cancer migration, invasion and EMT by regulating WDR66

Zhang, Yayuan; Xiao, Xiaojun; Zhou, Wenbing; Hu, Jintao; Zhou, Dongxian

doi:10.1007/s11626-019-00361-4

Cited by 22 publications

(17 citation statements)

References 32 publications

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“…Similar phenomena were also observed by Zhang et al. that the overexpression of FBXL19-AS1 in breast cancer cells promoted cell migration and EMT ( 30 ). FBXL19-AS1 was also significantly up-regulated in lung adenocarcinoma (LUAD) tissues, and the high expression of FBXL19-AS1 in LUAD was associated with poor prognosis.…”

Section: Discussionsupporting

confidence: 85%

“…In our study, FBXL19-AS1 was identified as a potential oncogene through integrated analysis of six GEO microarray datasets and TCGA LIHC dataset. Previous studies have shown that FBXL19-AS1 was significantly increased in breast cancer ( 13 , 14 , 30 ), lung cancer ( 15 , 16 , 31 ), osteosarcoma ( 17 ), colorectal cancer ( 18 ), cervical cancer ( 32 ), and glioma ( 33 ), and participated in the migration, proliferation and survival of tumor cells. Dong et al.…”

Section: Discussionmentioning

confidence: 99%

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Identify and Validate the Transcriptomic, Functional Network, and Predictive Validity of FBXL19-AS1 in Hepatocellular Carcinoma

Zhang

Zhu

et al. 2020

Front. Oncol.

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Hepatocellular carcinoma (HCC) is one of the most common neoplastic diseases worldwide. Available biomarkers are not sensitive enough for the diagnosis of HCC, hence seeking new biomarkers of HCC is urgent and challenging. The purpose of this study was to investigate the role of F-box and leucine-rich repeat protein 19-antisense RNA 1 (FBXL19-AS1) through a functional network and inquire into its diagnostic and prognostic value in HCC. A comprehensive strategy of genomic data mining, bioinformatics and experimental validation was used to evaluate the clinical value of FBXL19-AS1 in the diagnosis and prognosis of HCC and to identify the pathways in which FBXL19-AS1 might be involved. FBXL19-AS1 was up-regulated in HCC tissues, and its high expression was associated with TNM stage and poor prognosis of HCC patients. The combination of FBXL19-AS1 and alpha-fetoprotein (AFP) in plasma could prominently improve the diagnostic validity for HCC. FBXL19-AS1 might stabilize FBXL19 to reduce the amount of macrophage M1, and then promote the occurrence and development of HCC. Meanwhile, FBXL19-AS1 might participate in regulating HCC related pathways through FBXL19-AS1-miRNA-mRNA network. Our findings indicated that FBXL19-AS1 not only serves as a potential biomarker for HCC diagnosis and prognosis, but also might be functionally carcinogenic.

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Section: Discussionsupporting

confidence: 85%

Section: Discussionmentioning

confidence: 99%

Identify and Validate the Transcriptomic, Functional Network, and Predictive Validity of FBXL19-AS1 in Hepatocellular Carcinoma

Zhang

Zhu

et al. 2020

Front. Oncol.

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“…19 Further, FBXL19-AS1 was proved to be post-transcriptionally stabilized by LIN28A in breast cancer. 20 Nevertheless, the mechanism whereby FBXL19-AS1 was upregulated in cervical cancer remains unknown, and this needs to be further focused on in future studies. Thereupon we took the functional experiments to search the influence of FBXL19-AS1 silence on the behaviors of cervical cancer cells.…”

Section: Discussionmentioning

confidence: 99%

<p>Long Noncoding RNA FBXL19-AS1 Expedites Cell Growth, Migration and Invasion in Cervical Cancer by miR-193a-5p/PIN1 Signaling</p>

Wan¹,

Ni²,

Ding³

et al. 2020

CMAR

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Background: Cervical cancer is one of the most prevalent malignancies in gynecology with increasing incidence in recent years. Long noncoding RNAs (lncRNAs) have been reported to regulate human cancers including cervical cancer. F-box and leucine-rich repeat protein 19 antisense RNA 1 (FBXL19-AS1) have been unmasked to exert carcinogenic functions in several cancers except cervical cancer. Aim: Present study hammered at investigating the function and mechanism of FBXL19-AS1 in cervical cancer. Methods: RT-qPCR was utilized to test gene expression. EdU staining, colony formation, transwell, flow cytometry and TUNEL assays were applied for measuring the impact of FBXL19-AS1 on cervical cancer cell functions. Moreover, RIP, RNA pull-down and luciferase reporter assays were utilized for detecting the correlations among FBXL19-AS1, miR-193a-5p and PIN1 (peptidylprolyl cis/trans isomerase, NIMA-interacting 1). Results: FBXL19-AS1 exhibited elevated expression in cervical cancer tissues and cells. Silencing FBXL19-AS1 repressed cell proliferation through arresting cell cycle and stimulating apoptosis, and losing FBXL19-AS1 also restrained cell migration and invasion. Also, we discovered FBXL19-AS1 as a miR-193a-5p sponge, while miR-193a-5p was a tumor inhibitor in cervical cancer. Further, PIN1 was proved as the miR-193a-5p target, and FBXL19-AS1 augmented PIN1 expression in cervical cancer via sequestering miR-193a-5p. Of note, PIN1 accelerated the progression of cervical cancer, and its upregulation counteracted the impacts of depleted FBXL19-AS1 on cervical cancer cell functions. Conclusion: FBXL19-AS1 contributes to malignant phenotypes in cervical cancer by sponging miR-193a-5p and regulating PIN1.

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“…In our study, FBXL19-AS1 was identi ed as a potential oncogene through integrated analysis of 6 GEO microarray datasets and TCGA LIHC dataset. Previous studies have shown that FBXL19-AS1 is signi cantly increased in breast cancer [9][10]28], lung cancer [11][12]29], osteosarcoma [13] and colorectal cancer [14], and participates in the migration, proliferation and survival of tumor cells. The underlying function of FBXL19-AS1 in HCC has not been studied yet.…”

Section: Discussionmentioning

confidence: 99%

Role of FBXL19-AS1 in hepatocellular carcinoma by lncRNA–miRNA–mRNA network analysis and its diagnostic and prognostic value

Zhang

Zhu

et al. 2020

Preprint

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Background: Hepatocellular carcinoma (HCC) is one of the most common neoplastic diseases worldwide. Available biomarkers are not sensitive enough for the diagnosis of HCC, seeking new biomarkers of HCC is urgent and challenging. The purpose of this study was to investigate the role of F-box and leucine-rich repeat protein 19-antisense RNA 1 (FBXL19-AS1) through competing endogenous RNA (ceRNA) network and its diagnostic and prognostic value in HCC.Methods: A comprehensive strategy of genomic data mining, bioinformatics and experimental validation was used to evaluate the clinical value of FBXL19-AS1 in the diagnosis and prognosis of HCC and to identify the pathways that FBXL19-AS1 may be involved in.Results: FBXL19-AS1 was up-regulated in HCC, and its high expression was associated with TNM stage and poor prognosis of HCC patients. The combined use of plasma FBXL19-AS1 and alpha-fetoprotein (AFP) could prominently improve the diagnostic validity for HCC. FBXL19-AS1 might participate in regulating HCC related pathways, including hepatitis C, hepatitis B, microRNAs in cancer, cell cycle, viral carcinogenesis, and proteoglycans in cancer through ceRNA network.Conclusions: Our findings indicated that FBXL19-AS1 not only serves as a potential biomarker for HCC diagnosis and prognosis, but it may be functionally carcinogenic.

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LIN28A-stabilized FBXL19-AS1 promotes breast cancer migration, invasion and EMT by regulating WDR66

Cited by 22 publications

References 32 publications

Identify and Validate the Transcriptomic, Functional Network, and Predictive Validity of FBXL19-AS1 in Hepatocellular Carcinoma

Identify and Validate the Transcriptomic, Functional Network, and Predictive Validity of FBXL19-AS1 in Hepatocellular Carcinoma

<p>Long Noncoding RNA FBXL19-AS1 Expedites Cell Growth, Migration and Invasion in Cervical Cancer by miR-193a-5p/PIN1 Signaling</p>

Role of FBXL19-AS1 in hepatocellular carcinoma by lncRNA–miRNA–mRNA network analysis and its diagnostic and prognostic value

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