Limosilactobacillus reuteri in Health and Disease

Abstract

Limosilactobacillus reuteri is a microorganism with valuable probiotic qualities that has been widely employed in humans to promote health. It is a well-studied probiotic bacterium that exerts beneficial health effects due to several metabolic mechanisms that enhance the production of anti-inflammatory cytochines and modulate the gut microbiota by the production of antimicrobial molecules, including reuterin. This review provides an overview of the data that support the role of probiotic properties, and the antimicrobial and immunomodulatory effects of some L. reuteri strains in relation to their metabolite production profile on the amelioration of many diseases and disorders. Although the results discussed in this paper are strain dependent, they show that L. reuteri, by different mechanisms and various metabolites, may control body weight and obesity, improve insulin sensitivity and glucose homeostasis, increase gut integrity and immunomodulation, and attenuate hepatic disorders. Gut microbiota modulation by ingesting probiotic L. reuteri strains could be a promising preventative and therapeutic approach against many diseases and disorders.

Polygonatum kingianum Polysaccharides Enhance the Preventive Efficacy of Heat-Inactivated Limosilactobacillus reuteri WX-94 against High-Fat-High-Sucrose-Induced Liver Injury and Gut Dysbacteriosis

“…54−59 Notably, the contents of these metabolites were significantly higher in the cell-free supernatant of L. reuteri incubated with PKP than in the MRS-cultured L. reuteri and PKP dissolved medium. Besides, L. reuteri has enzymes (e.g., araT, fldH, and amiE) necessary to metabolize dietary tryptophan into indole derivatives (such as indole-3-lactic acid and indole-3-carbinol) with antioxidation, anti-inflammation, and antihyperglycemia properties, 60,61 in line with our results. Besides, our data also showed that our L. reuteri strain utilized fructose, lactose, glucose, and certain amino acids in the medium while also decarboxylating 4-hydroxycinnamic acid and caffeic acid, resulting in the production of 4-vinylplenols, the compound with great impact on the sensorial characteristics of foods.…”

Cholesterol lowering in diet-induced hypercholesterolemic mice using Lactobacillus bile salt hydrolases with different substrate specificities

“…Notably, L. reuteri and L. johnsonii have been widely reported in various studies for their probiotic effects. 28–30 These findings demonstrate that recombinant BSH derived from YB81 can ameliorate dysbiosis induced by HCD, which may be linked to its CHOL-lowering capabilities.…”

Investigation of the therapeutic effect of Hedan tablets on high‐fat diet‐induced obesity in rats by GC–MS technology and 16S ribosomal RNA gene sequencing

“…Lactobacillus produces lactic acid and obtains energy from the fermentation of lactose, glucose, and other sugars, metabolizing lactic acid into acetic acid (Fujinaga et al, 2022). Limosilactobacillus strains exhibit the ability to modulate energy homeostasis, alter intestinal microbiome composition, synthesize SCFAs, and enhance intestinal barrier function (Abuqwider et al, 2022; Kim et al, 2021). Ruminococcus is the most common bacterium in the gut, capable of producing SCFAs, stabilizing the intestinal barrier (Lakshmanan et al, 2022; Salas‐Perez et al, 2023; Zhang et al, 2022), and playing a “cornerstone” role in degrading dietary‐resistant starch.…”