Limosilactobacillus reuteri DSM 17938 reverses gut metabolic dysfunction induced by Western diet in adult rats

Abuqwider, Jumana; Di Porzio, Angela; Barrella, Valentina; Gatto, Cristina; Sequino, Giuseppina; De Filippis, Francesca; Crescenzo, Raffaella; Spagnuolo, Maria Stefania; Cigliano, Luisa; Mauriello, Gianluigi; Iossa, Susanna; Mazzoli, Arianna

doi:10.3389/fnut.2023.1236417

Cited by 5 publications

(1 citation statement)

References 79 publications

(82 reference statements)

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“…It has been demonstrated that the consumption of an HF/HFr diet over 8 wk resulted in both gut dysbiosis and a change in the permeability of the gut barrier. As an effective probiotic, Limosilactobacillus reuteri DSM 17938 may be used to prevent the detrimental effects of an HF/HFr diet on the gut[ 126 ].…”

Section: Prevention and Management Of Metabolic Disordersmentioning

confidence: 99%

Assessing the impact of concurrent high-fructose and high-saturated fat diets on pediatric metabolic syndrome: A review

Vargas-Vargas,

González-Montoya,

Torres-Isidro

et al. 2024

World J Clin Pediatr

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High-saturated fat (HF) or high-fructose (HFr) consumption in children predispose them to metabolic syndrome (MetS). In rodent models of MetS, diets containing individually HF or HFr lead to a variable degree of MetS. Nevertheless, simultaneous intake of HF plus HFr have synergistic effects, worsening MetS outcomes. In children, the effects of HF or HFr intake usually have been addressed individually. Therefore, we have reviewed the outcomes of HF or HFr diets in children, and we compare them with the effects reported in rodents. In humans, HFr intake causes increased lipogenesis, hypertriglyceridemia, obesity and insulin resistance. On the other hand, HF diets promote low grade-inflammation, obesity, insulin resistance. Despite the deleterious effects of simultaneous HF plus HFr intake on MetS development in rodents, there is little information about the combined effects of HF plus HFr intake in children. The aim of this review is to warn about this issue, as individually addressing the effects produced by HF or HFr may underestimate the severity of the outcomes of Western diet intake in the pediatric population. We consider that this is an alarming issue that needs to be assessed, as the simultaneous intake of HF plus HFr is common on fast food menus.

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Section: Prevention and Management Of Metabolic Disordersmentioning

confidence: 99%

Assessing the impact of concurrent high-fructose and high-saturated fat diets on pediatric metabolic syndrome: A review

Vargas-Vargas,

González-Montoya,

Torres-Isidro

et al. 2024

World J Clin Pediatr

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Limosilactobacillus reuteri DSM 17938 relieves inflammation, endoplasmic reticulum stress, and autophagy in hippocampus of western diet‐fed rats by modulation of systemic inflammation

Mazzoli,

Spagnuolo,

De Palma

et al. 2024

BioFactors

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The consumption of western diets, high in fats and sugars, is a crucial contributor to brain molecular alterations, cognitive dysfunction and neurodegenerative diseases. Therefore, a mandatory challenge is the individuation of strategies capable of preventing diet‐induced impairment of brain physiology. A promising strategy might consist in the administration of probiotics that are known to influence brain function via the gut‐brain axis. In this study, we explored whether Limosilactobacillus reuteri DSM 17938 (L. reuteri)‐based approach can counteract diet‐induced neuroinflammation, endoplasmic reticulum stress (ERS), and autophagy in hippocampus, an area involved in learning and memory, in rat fed a high fat and fructose diet. The western diet induced a microbiota reshaping, but L. reuteri neither modulated this change, nor the plasma levels of short‐chain fatty acids. Interestingly, pro‐inflammatory signaling pathway activation (increased NFkB phosphorylation, raised amounts of toll‐like receptor‐4, tumor necrosis factor‐alpha, interleukin‐6, GFAP, and Haptoglobin), as well as activation of ERS (increased PERK and eif2α phosphorylation, higher C/EBP‐homologous protein amounts) and autophagy (increased beclin, P62‐sequestosome‐1, and LC3 II) was revealed in hippocampus of western diet fed rats. All these hippocampal alterations were prevented by L. reuteri administration, showing for the first time a neuroprotective role of this specific probiotic strain, mainly attributable to its ability to regulate western diet‐induced metabolic endotoxemia and systemic inflammation, as decreased levels of lipopolysaccharide, plasma cytokines, and adipokines were also found. Therapeutic strategies based on the use of L. reuteri DSM17938 could be beneficial in reversing metabolic syndrome‐mediated brain dysfunction and cognitive decline.

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Modulation of the Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway by the probiotic Limosilactobacillus reuteri DSM 17938 prevents diet-induced rat brain dysfunction

Mazzoli,

Stefania Spagnuolo,

Nazzaro

et al. 2024

Journal of Functional Foods

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Limosilactobacillus reuteri DSM 17938 reverses gut metabolic dysfunction induced by Western diet in adult rats

Cited by 5 publications

References 79 publications

Assessing the impact of concurrent high-fructose and high-saturated fat diets on pediatric metabolic syndrome: A review

Assessing the impact of concurrent high-fructose and high-saturated fat diets on pediatric metabolic syndrome: A review

Limosilactobacillus reuteri DSM 17938 relieves inflammation, endoplasmic reticulum stress, and autophagy in hippocampus of western diet‐fed rats by modulation of systemic inflammation

Modulation of the Nuclear factor erythroid 2-related factor 2 (Nrf2) pathway by the probiotic Limosilactobacillus reuteri DSM 17938 prevents diet-induced rat brain dysfunction

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