Limosilactobacillus fermentum CECT5716: Clinical Potential of a Probiotic Strain Isolated from Human Milk

Abstract

Breastfeeding provides the ideal nutrition for infants. Human milk contains a plethora of functional ingredients which foster the development of the immune system. The human milk microbiota predominantly contributes to this protective effect. This is mediated by various mechanisms, such as an antimicrobial effect, pathogen exclusion and barrier integrity, beneficial effects on the gastrointestinal microbiota, vitamin synthesis, immunity enhancement, secreted probiotic factors, and postbiotic mechanisms. Therefore, human milk is a good source for isolating probiotics for infants who cannot be exclusively breastfed. One such probiotic which was isolated from human milk is Limosilactobacillus fermentum CECT5716. In this review, we give an overview of available interventional studies using Limosilactobacillus fermentum CECT5716 and summarise preclinical trials in several animal models of different pathologies, which have given first insights into its mechanisms of action. We present several randomised clinical studies, which have been conducted to investigate the clinical efficacy of the Limosilactobacillus fermentum CECT5716 strain in supporting the host’s health.

Christensenella minuta interacts with multiple gut bacteria

“…Among the 11 MAGs exhibiting a positive correlation with SJ-2, Eubacterium sp. AM28-29, D. pneumosintes and Tractidigestivibacter scatoligene were predicted to have the highest correlation with SJ-2 (SCC > 0.9), T. scatoligenes , Limosilactobacillus fermentum , F. praussnitzii and Roseburia inulinivorans were of great interest as potential probiotics in previous researches ( Lopez-Siles et al, 2017 ; Sankaranarayanan et al, 2021 ; Hao et al, 2023 ; Ozen et al, 2023 ). As a comparison, several species of Bifidobacterium and Bacteroidetes exhibited negative associations with SJ-2 ( Figure 4 , Supplementary Table S13 ).…”

Short-chain fatty acids in breast milk and their relationship with the infant gut microbiota

“…Breast milk is rich in nutrients and is considered as the most ideal natural food for infants aged 0–6 months (Gates et al, 2023 ; Szugye et al, 2023 ). Not only it can ensure infants' growth; certain breast milk components also play essential roles in regulating intestinal microbiota colonization and metabolism; serve as anti-inflammatory and anti-infectious agents; and perform many other functions (Fougère et al, 2023 ; Ouyang et al, 2023 ; Ozen et al, 2023 ).…”