Received (Day Month Year) Revised (Day Month Year)Within the framework of a model Universe with time variable space dimensions (TVSD), known as decrumpling or TVSD model, we study TVSD chaotic inflation and obtain dynamics of the inflaton, scale factor and spatial dimension. We also study the quantum fluctuations of the inflaton field and obtain the spectral index and its running in this model. Two classes of examples have been studied and comparisons made with the standard slow-roll formulae. We compare our results with the recent Wilkinson Microwave Anisotropy Probe (WMAP) data.