Limiting the proliferation and reactivity of retinal Müller cells during experimental retinal detachment: the value of oxygen supplementation

Lewis, Geoffrey P.; Mervin, Kyle; Valter, Krisztina; Maslim, Juliani; Kappel, Peter J.; Stone, Jonathan; Fisher, Steven K.

doi:10.1016/s0002-9394(99)00103-8

Cited by 102 publications

(59 citation statements)

References 8 publications

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“…7 We have preferred the term 'retinopathy,' to describe the results of detachment because it involves a variety of complex but characteristic cellular responses in many different retinal cell types. 8 Most importantly, many of the events initiated by detachment can be halted or reversed by reattachment, or by providing certain specific biological factors such as the trophic factor known as 'brain-derived neurotrophic factor' (BDNF), 9 or an increase in environmental oxygen (hyperoxia).…”

Section: Resultsmentioning

confidence: 99%

“…21 Reattachment can stop this process; treatment with BDNF or hyperoxia can diminish it. 3,8 When the retina is reattached after 1 h of detachment there is almost no redistribution (Figure 5c). If it remained detached for a day before reattachment there is a significant response in some cells but not others (Figure 5d), although the response was greatly attenuated compared to that in the retina that remained detached for 3 days (Figure 5b).…”

Section: Rod Opsin Redistributionmentioning

confidence: 93%

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Animal models of retinal detachment and reattachment: identifying cellular events that may affect visual recovery

Lewis

Charteris²,

Sethi³

et al. 2002

Eye

122

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Retinal detachment continues to be a significant cause of visual impairment, either through the direct effects of macular detachment or through secondary complications such as subretinal fibrosis or proliferative vitreoretinopathy. Animal models can provide us with an understanding of the cellular mechanisms at work that account for the retinopathy induced by detachment and for the generation of secondary effects. As we understand the mechanisms involved, animal models can also provide us with opportunities to test therapeutic agents that may reduce the damaging effects of detachment or improve the outcome of reattachment surgery. They may also reveal information of use to understanding other causes of blindness rooted in retinal defects or injuries. Understanding the effects of detachment (and reattachment) are likely to become even more important as surgeons gain skills in subretinal surgical techniques and macular translocation, both of which will generate short-lived detachments. Here we discuss the fundamental events that occur after detachment, present changes associated with reattachment, and discuss retinal changes that may affect the return of vision.

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Section: Resultsmentioning

confidence: 99%

Section: Rod Opsin Redistributionmentioning

confidence: 93%

Animal models of retinal detachment and reattachment: identifying cellular events that may affect visual recovery

Lewis

Charteris²,

Sethi³

et al. 2002

Eye

122

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“…In a study by Lewis et al, 24 a cat model of RD was placed in a hyperoxic environment and showed a stabilization of glutamaterelated neurochemical signatures. NMDA receptor antagonists, such as memantine and dextromethorphan, may also prove to be beneficial in attenuating retinal cell death secondary to glutamate excitotoxicity.…”

Section: Discussionmentioning

confidence: 99%

“…10,24,25 Accumulation of glutamate has been observed in animal models of retinal ischaemia, [26][27][28][29] and animal studies of RD have shown excess glutamate levels and lower glutamine synthetase (GS) activity within the retina. [30][31][32] Moreover, increased levels of glutamate were recently found in the vitreous fluid of human subjects with RD.…”

Section: Introductionmentioning

confidence: 99%

Amino-acid levels in subretinal and vitreous fluid of patients with retinal detachment

Bertram

Bula

Pulido

et al. 2007

Eye

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Purpose To compare the concentration of amino acids in subretinal and vitreous fluid of patients with primary rhegmatogenous retinal detachment to that of control vitreous. Methods This prospective, observational study measured amino-acid levels in subretinal fluid of patients undergoing scleral buckle placement (n ¼ 20) and vitreous fluid in patients undergoing pars plana vitrectomy (n ¼ 5) for primary retinal detachment. Vitreous fluid from patients undergoing vitrectomy for macular hole (n ¼ 7) or epiretinal membrane (n ¼ 3) served as a control. Subretinal fluid and control vitreous were analysed using high-pressure liquid chromatography. Retinal detachment vitreous was analysed using capillary electrophoresis-laser-induced fluorescence. Results Mean levels of glutamate (27.071.7 lM), aspartate (4.174.0 lM), and glycine (44.1731.0 lM) in subretinal fluid and glutamate (13.4711.9 lM) in the vitreous were significantly elevated in retinal detachment compared to control vitreous. A significant, positive association was observed between levels of aspartate and glutamate in subretinal fluid (Spearman's correlation coefficient: 0.74, Po0.01). Mean arginine levels did not differ significantly between subretinal fluid and control vitreous. Levels of alanine, tyrosine, valine, isoleucine, leucine, and phenylalanine were significantly lower in subretinal fluid compared to control vitreous (all Po0.01). Conclusions Glutamate levels in subretinal fluid and vitreous of patients with primary retinal detachment is significantly elevated in comparison to control vitreous. This finding lends further support to the hypothesis that elevated glutamate levels may result from ischaemia of the outer retina secondary to retinal detachment.

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“…Oxygen therapy has been shown to preserve both rods and cone photoreceptors in cats after retinal detachment, 17 to help maintain normal structure and function of Mueller cells, to reduce surgical trauma, and to mitigate the effect of detachment in Mueller cell activity. 17,47 …”

mentioning

confidence: 99%

Vision Improvement in Retinal Degeneration Patients by Implantation of Retina Together with Retinal Pigment Epithelium

Radtke

Aramant

Petry

et al. 2008

American Journal of Ophthalmology

225

191

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Limiting the proliferation and reactivity of retinal Müller cells during experimental retinal detachment: the value of oxygen supplementation

Cited by 102 publications

References 8 publications

Animal models of retinal detachment and reattachment: identifying cellular events that may affect visual recovery

Animal models of retinal detachment and reattachment: identifying cellular events that may affect visual recovery

Amino-acid levels in subretinal and vitreous fluid of patients with retinal detachment

Vision Improvement in Retinal Degeneration Patients by Implantation of Retina Together with Retinal Pigment Epithelium

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