Limited value of 18F-FDG PET/CT and S-100B tumour marker in the detection of liver metastases from uveal melanoma compared to liver metastases from cutaneous melanoma

Abstract

FDG PET/CT and serum S-100B are not sensitive enough for the detection of liver metastases from UM, whereas liver metastases from cutaneous melanoma are reliably FDG positive and lead regularly to increased S-100B tumour markers. The reason for the lower FDG uptake in UM liver metastases remains unclear. We recommend to perform combined contrast-enhanced PET/CT in order to detect FDG-negative liver metastases from UM.

MRI in the detection of hepatic metastases from high-risk uveal melanoma: a prospective study in 188 patients

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Preclinical Melanoma Imaging with 68Ga-Labeled α-Melanocyte-Stimulating Hormone Derivatives Using PET

“…With high sensitivity and spatial resolution, positron emission tomography (PET) has emerged as a powerful imaging technique for such purpose. While 2-[ 18 F]Fluorodeoxyglucose PET coupled with computed tomography (CT) is highly accurate in detecting metastatic disease in cutaneous melanomas 6, this modality lacks sensitivity for early nodal metastases, and liver metastases in uveal melanomas 7, 8.…”

PET/CT, MR, and PET/MR in Lymphoma and Melanoma

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