Limited representation of drinking-water contaminants in pregnancy–birth cohorts

Makris, Konstantinos C.; Andra, Syam S.

doi:10.1016/j.scitotenv.2013.08.012

Cited by 10 publications

(9 citation statements)

References 90 publications

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“…In this growing body of evidence, however, assessment of disinfection by‐products concentrations, in particular trihalomethanes (THMs) (Makris and Andra, ), and of semi‐volatile organic compounds (SVOCs) in the air of dwellings is still limited, and the literature on cumulative exposure to an array of chemical families is scarce (Hulin et al., ).…”

Section: Introductionmentioning

confidence: 99%

Volatile and semi-volatile organic compounds of respiratory health relevance in French dwellings

et al. 2015

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Over the last decades, the prevalence of childhood respiratory conditions has dramatically increased worldwide. Considering the time spent in enclosed spaces, indoor air pollutants are of major interest to explain part of this increase. This study aimed to measure the concentrations of pollutants known or suspected to affect respiratory health that are present in dwellings in order to assess children's exposure. Measurements were taken in 150 homes with at least one child, in Brittany (western France), to assess the concentrations of 18 volatile organic compounds (among which four aldehydes and four trihalomethanes) and nine semi-volatile organic compounds (seven phthalates and two synthetic musks). In addition to descriptive statistics, a principal component analysis (PCA) was used to investigate grouping of contaminants. Formaldehyde was highly present and above 30 μg/m(3) in 40% of the homes. Diethyl phthalate, diisobutyl phthalate, and dimethylphthalate were quantified in all dwellings, as well as Galaxolide and Tonalide. For each chemical family, the groups appearing in the PCA could be interpreted in term of sources. The high prevalence and the levels of these compounds, with known or suspected respiratory toxicity, should question regulatory agencies to trigger prevention and mitigation actions.

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Section: Introductionmentioning

confidence: 99%

Volatile and semi-volatile organic compounds of respiratory health relevance in French dwellings

et al. 2015

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“…Indeed, water contaminants have received the least attention among all other environmental risks in the literature. However, pregnant and lactating women may consume more drinking water than non-pregnant women, increasing their daily intake of water contaminants [ 40 ].…”

Section: Discussionmentioning

confidence: 99%

Comparison of the Effect on Fetal Growth of a Mixture of Atrazine and Nitrates in Drinking Water and of Active Tobacco Exposure during Pregnancy

Carles

Albouy-Llaty

Dupuis

et al. 2021

IJERPH

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Active tobacco exposure during pregnancy is a known determinant of fetal growth. Nitrates and atrazine metabolites in drinking water may affect fetal growth as a mixture of endocrine disruptors (ED). We aimed to determine whether EDC have an additional effect on fetal growth compared to active tobacco exposure. A historic cohort study was carried out with a sample stratified with regard to the maternity unit, drinking water exposure, and year of birth. The women included were living in Deux-Sèvres, had given birth between 2005 and 2010 in three selected maternity units, and ultrasound data were available in their obstetrical records. Mixed linear models were used to analyze fetal weight evolution from the second trimester to the time of birth according to drinking water exposure to EDC mixture and active tobacco exposure. We included 558 mother-neonate couples, of whom 9% were exposed to high doses of the mixture and 21% to active tobacco smoking. There was no difference in fetal weight evolution according to drinking water mixture exposure (0.97 g; 95% CI [−3.01; 4.94]). We could not show a supplementary effect of mixture exposure in drinking-water on fetal growth as compared to active tobacco exposure. Further research is needed, using more precise methods to estimate EDC exposure.

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“…From a human health perspective, it is important to understand the factors and mechanisms promoting co-occurrence of water contaminants given the low-dose and mixtureeffect of these contaminants that has larger manifestation on an individual's health outcome based on the critical window of exposure during a person's life time (Itoh et al 2011;Toccalino et al 2012;Lampa et al 2012). Deficiencies in understanding human exposures to water contaminants and the need for new research foci to fill the gaps were recently reviewed by Makris and Andra (2014).…”

Section: Environmental and Public Health Implicationsmentioning

confidence: 99%

Co-occurrence profiles of trace elements in potable water systems: a case study

Andra

Makris

Charisiadis

et al. 2014

Environ Monit Assess

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Potable water samples (N = 74) from 19 zip code locations in a region of Greece were profiled for 13 trace elements composition using inductively coupled plasma mass spectrometry. The primary objective was to monitor the drinking water quality, while the primary focus was to find novel associations in trace elements occurrence that may further shed light on common links in their occurrence and fate in the pipe scales and corrosion products observed in urban drinking water distribution systems. Except for arsenic at two locations and in six samples, rest of the analyzed elements was below maximum contaminant levels, for which regulatory values are available. Further, we attempted to hierarchically cluster trace elements based on their covariances resulting in two groups; one with arsenic, antimony, zinc, cadmium, and copper and the second with the rest of the elements. The grouping trends were partially explained by elements' similar chemical activities in water, underscoring their potential for co-accumulation and co-mobilization phenomena from pipe scales into finished water. Profiling patterns of trace elements in finished water could be indicative of their load on pipe scales and corrosion products, with a corresponding risk of episodic contaminant release. Speculation was made on the role of disinfectants and disinfection byproducts in mobilizing chemically similar trace elements of human health interest from pipe scales to tap water. It is warranted that further studies may eventually prove useful to water regulators from incorporating the acquired knowledge in the drinking water safety plans.

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Limited representation of drinking-water contaminants in pregnancy–birth cohorts

Cited by 10 publications

References 90 publications

Volatile and semi-volatile organic compounds of respiratory health relevance in French dwellings

Volatile and semi-volatile organic compounds of respiratory health relevance in French dwellings

Comparison of the Effect on Fetal Growth of a Mixture of Atrazine and Nitrates in Drinking Water and of Active Tobacco Exposure during Pregnancy

Co-occurrence profiles of trace elements in potable water systems: a case study

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