Limited relationships between two-year changes in sulcal morphology and other common neuroimaging indices in the elderly

Alterations of the cerebral cortex in sporadic small vessel disease: A systematic review of in vivo MRI data

“…15 The relationships between cortical thickness and the volume of WMH were tested in three cross-sectional studies. 13,16,18 A significant inverse relationship was reported in one. 16 In this study, subjects were divided between ''abnormal'' and ''normal'' cortical thickness.…”

“…[15][16][17][18] Sample sizes were highly heterogeneous, ranging from 31 to 740 subjects. [11][12][13][14][15][16][17][18] Mean age was around 75 years in four studies, 12,13,15,16 lower in three others (55 in one and 65 in two), 11,14,18 while age ranged from 19 to 79 years in one. 17 In all studies, subjects were scanned using 3DT1 1-mm isotropic sequences.…”

“…By contrast, there was no significant association between cortical thickness and the volume of WMH in two other studies. 13,18 The relationships between sulcal width and the volume of WMH were evaluated in two different studies and revealed a significant association independent of age in one, 18 but not in the other. 13 However, the interpretation of these non-significant results is difficult as these analyses were not the primary aim of those studies and detailed results were not provided.…”

“…13,18 The relationships between sulcal width and the volume of WMH were evaluated in two different studies and revealed a significant association independent of age in one, 18 but not in the other. 13 However, the interpretation of these non-significant results is difficult as these analyses were not the primary aim of those studies and detailed results were not provided. 13,18 In summary, significant relationships between cortical gray matter volume and WMH are consistently observed with VBM approaches in communitydwelling elderly but links between WMH and other cortical parameters are inconsistently detected.…”

“…13 However, the interpretation of these non-significant results is difficult as these analyses were not the primary aim of those studies and detailed results were not provided. 13,18 In summary, significant relationships between cortical gray matter volume and WMH are consistently observed with VBM approaches in communitydwelling elderly but links between WMH and other cortical parameters are inconsistently detected. The cortical impact of lacunes and/or microbleeds is not evaluated yet in these populations and only few data are available to determine whether the cortical alterations are actually secondary to effects of SVD rather than to concomitant prodromal AD.…”