Abstract:Lung granulomas are the pathologic hallmark of Tuberculosis (TB). T cells are a major cellular component of tuberculosis lung granulomas and are known to play an important role in containment and progression of Mtb infection. We used cynomolgus macaques, a non-human primate model that recapitulates human TB, with clinically active disease and latent infection, to understand the functional characteristics and dynamics of T cells in individual granulomas and to correlate T cell cytokine response of granulomas to… Show more
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